Clinical efficacy of acute respiratory viral infections prevention in patients with chronic heart failure

Budnevsky, A. V.; Shurupova, A D; Kravchenko, A. Ya.; Tokmachev, Roman

doi:10.26442/00403660.2019.03.000111

Cited by 7 publications

(5 citation statements)

References 9 publications

(8 reference statements)

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“…Russian medical journals have published a voluminous corpus of studies on using the antiviral action of Tilorone or Cridanimod for both treatment and prophylaxis (partially reviewed in [ 17 ]). Recent examples are [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

et al. 2022

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The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to induce interferon. Both drugs induce interferon in mice but not in humans. This study investigates whether these compounds have the antiviral activity in mice and rats since rats more closely resemble the human response. Viral-infection models were created in CD-1 mice and Wistar rats. Three strains of Venezuelan equine encephalitis virus were tested for the performance in these models. One virus strain is the molecularly cloned attenuated vaccine. The second strain has major virulence determinants converted to the wild-type state which are present in virulent strains. The third virus has wild-type virulence determinants, and in addition, is engineered to express green fluorescent protein. Experimentally infected animals received Tilorone or Cridanimod, and their treatment was equivalent to the pharmacopoeia-recomended human treatment regimen. Tilorone and Cridanimod show the antiviral activity in mice and rats and protect the mice from death. In rats, both drugs diminish the viremia. These drugs do not induce interferon-alpha or interferon-beta in rats. The presented observations allow postulating the existence of an interferon-independent and species-independent mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

et al. 2022

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“…Patients with comorbid COPD and CHF are in a state of prolonged hypoxia: permanent (chronic respiratory failure) or intermittent [9,10,11]. Intermittent hypoxia can occur during exercise, exacerbation of COPD or CHF decompensation and during sleep.…”

Section: Discussionmentioning

confidence: 99%

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Tokmachev¹,

Budnevsky²,

Kravchenko³

et al. 2022

PJMHS

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Despite all the efforts of medical services, the socio-economic damage caused by chronic heart failure (CHF) is increasing. Approximately 10-40% of patients with CHF also suffer from chronic obstructive pulmonary disease (COPD). The comorbid course of these pathologies aggravates the prognosis of patients. Moderate physical activity is recommended as a non-drug therapy for both pathologies. The aim of the study: was to evaluate the effectiveness of physical rehabilitation in patients with chronic heart failure and chronic obstructive pulmonary disease by determining the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6, TNF-α. Methods: The study included 240 patients with CHF. After the initial examination, the patients were divided into groups depending on the presence or absence of COPD and the value of LVEF. Subsequently, each group was divided into a subgroup that took part in physical rehabilitation in addition to standard medical therapy and another one consist of patients that received only standard therapy. A year later, the levels of NT-proBNP, high-sensitivity C-reactive protein, IL-1β, IL-6 and TNF-α were re-determined. Results and Conclusion: CHFpEF patients have higher levels of hs-CRP and pro-inflammatory cytokines compared to patients with CHFrEF. The combination of COPD and CHF enhances systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP in comparison with the isolated course of CHF. Physical rehabilitation in patients with a comorbid course of COPD and CHF is accompanied by a significant decrease in the levels of pro-inflammatory cytokines, hs-CRP and NT-proBNP. Keywords: chronic heart failure, chronic obstructive pulmonary disease, physical rehabilitation

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“…Atrial fibrosis triggers are the activation of the renin-angiotensinaldosterone system, inflammation, and oxidative stress. (5)(6)(7)(8) Furthermore, with an increase in the severity of symptoms of heart failure, the incidence and severity of AF increases.…”

Section: Introductionmentioning

confidence: 99%

Predictive Markers of Atrial Fibrillation Progression in Heart Failure

Tokmachev¹,

Kravchenko²,

Budnevsky³

et al. 2020

IJBM

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Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical practice. It has been found that the presence of chronic heart failure increases the risk of AF by 5 times. Furthermore, with an increase in the severity of symptoms of heart failure, the incidence and severity of AF increases. To date, markers of AF progression are not clearly defined. In this regard, it is relevant and reasonable to identify such markers in patients with heart failure. The aim of this research was to study the prognostic value of the 6-minute walk test (6MWT), NT-proBNP level, and left ventricular diastolic dysfunction for AF progression in patients with chronic heart failure (CHF). The study involved 96 participants with stable Class II and III CHF (the NYHA Functional Classification), who were included in the regional registry of CHF patients in September-November 2014. The data obtained showed that in patients with CHF, an increase in the level of Nt-proBNP, impaired myocardial relaxation, and a decrease in 6MWT distance may serve as predictors of AF progression with the transition of arrhythmias to stable forms.

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Clinical efficacy of acute respiratory viral infections prevention in patients with chronic heart failure

Cited by 7 publications

References 9 publications

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

Physical Rehabilitation in Patients with Chronic Heart Failure and Chronic Obstructive Pulmonary Disease

Predictive Markers of Atrial Fibrillation Progression in Heart Failure

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