Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma

Topical 5-fluorouracil for granular myringitis: a double-blinded study

“…9 The major complication of topical 5-FU is chronic ulceration. 15 This was comparable to our topical use of 5-FU cream three times with two-week intervals in granular myringitis patients. 14 In the field of otology, Smith in 1985 assessed the use of topical 5-FU in the management of cholesteatoma and unwanted mucus-secreting cells.…”

“…Five-fluorouracil is a clear, colourless liquid which is given intravenously. 15 The safety of topical use of 5-FU on auditory and vestibular structures has recently been evaluated in a guinea pig model. Five-fluorouracil has become accepted because of its efficacy, economical price and relative absence of side effects.…”

A Comparison of Patterns of Disease Extension in Keratosis Obturans and External Auditory Canal Cholesteatoma

“…On the other hand, patients with EACC should undergo surgical removal of the entire cholesteatoma and all necrotic bone to prevent progression and continuing erosion. Conservative management is appropriate during an initial observation period to assess progression of the disease or in patients with a contraindication to surgery or who refuse surgery (1,10). Treatment of these disorders should focus on removing keratin debris to provide an open, clean canal and prevention of extension of the disease into other areas, such as the middle ear (11).…”

Ear canal cholesteatoma: meta-analysis of clinical characteristics with update on classification, staging and treatment

“…Studies testing regular treatment by chemotherapeutics also showed sufficient results, albeit in an experimental setting. However, the alternative conservative treatment [27] requires permanent and extensive follow-up (Fig. 3).…”