Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase

Yamashita, Yasunori; Mae, Megumi; Oohira, Masayuki; Ohba, Seigo; Asahina, Izumi; Yoshimura, Atsutoshi

doi:10.3390/ph15080924

Cited by 7 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The photosensitizer and the optical fiber placed in the periodontal and peri-implant pockets could reach the root or implant surface before activation with the laser light [ 50 ]. The big amount of randomized controlled clinical trials has shown that a-PDT and scale root planning (SRP) can cause significant enhancements in PPD and clinical attachment level than SRP alone [ 32 , 33 , 51 , 52 , 53 ]. The aPDT properties against bacteria and virus agents could be realized with different lasers and photosensitive substances.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Sologova,

Petukhova,

Podoplelova

et al. 2023

Dentistry Journal

View full text Add to dashboard Cite

Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials. All the studies in this systematic review, were randomized, the risk of bias 2 (ROB 2) were assessed; Results: Considering the inclusion and exclusion criteria, we included 10 randomized clinical trials, published up to 2023 investigating the application of photodynamic therapy as a part of management of inflammatory diseases in oral cavity. The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Sologova,

Petukhova,

Podoplelova

et al. 2023

Dentistry Journal

View full text Add to dashboard Cite

show abstract

“…with periodontitis. 89 Yamashita et al 90 showed PDT-irrigation combination therapy with irrigation alone in maintenance patients and found that BOP significantly decreased from 100% to 33% in the PDT-irrigation group. Many studies showed that PDT could significantly reduce PPD and gain more CAL and SBI than SRP alone.…”

Section: Clinical Effects Of the Pdt-assisted Srpmentioning

confidence: 99%

“…showed that multiple applications of PDT significantly improved bleeding on probing (BOP) compared with SRP alone, which also can be seen among geriatric patients with periodontitis 89 . Yamashita et al 90 . showed PDT‐irrigation combination therapy with irrigation alone in maintenance patients and found that BOP significantly decreased from 100% to 33% in the PDT‐irrigation group.…”

Section: Clinical Effect Of Pdt In the Treatment Of Periodontitismentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

show abstract

“…On the other hand, there is limited proof that antibacterial PDT is beneficial during the periodontal maintenance phase. 20 Periodontal diseases have been successfully treated with PDT. Due to the difficulties of accessing confined spaces, mechanical removal of gold standard biofilm in the therapeutic management of periodontal diseases is impaired in difficult-toaccess locations.…”

Section: Evidence From Literaturementioning

confidence: 99%

Photodynamic therapy and periodontal disease

Batwa,

Alqahtani,

Alzahrani

et al. 2023

Int J Community Med Public Health

View full text Add to dashboard Cite

Periodontal diseases are global health concern since they affect almost 20-50% of global population and are widespread in both developed and developing countries. Periodontal disease develops as result of persistent infection caused by different periodontopathic bacteria and inflammation of tooth's supporting tissue. Traditional methods of periodontal care involve mechanical removal of biofilm and using antibiotics and antibacterial disinfectants as supplemental measure. However, in locations with restricted access, removal of plaque and decrease in quantity of pathogenic organisms may suffer. Furthermore, increased antibiotic resistance has led to development of newer therapeutic modalities, including photodynamic therapy (PDT). Application of PDT in periodontics, such as pocket debridement, gingivitis, and aggressive periodontitis, continues to develop into fully developed clinical therapeutic modality and is regarded as potential new strategy for eliminating pathogenic bacteria in periodontitis. Photosensitizer activated by light of certain wavelength in presence of O2 is used in PDT, potent laser-initiated photochemical reaction. Because traditional therapy, such as scaling and root planing, is ineffective at entirely eliminating periodontal infections, especially in deep periodontal pockets, antimicrobial PDT may be viewed as alternate therapeutic approach. Additionally, dual selectivity of PDT, which restricts damage to healthy tissues, gives it competitive advantage over alternative therapies. Purpose of this research is to review the available information about PDT and periodontal disease.

show abstract

Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase

Cited by 7 publications

References 33 publications

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Photodynamic therapy in periodontitis: A narrative review

Photodynamic therapy and periodontal disease

Contact Info

Product

Resources

About