Clinical efficacy and safety of Traditional Chinese Medicine combined with Western Medicine in patients with diabetic acute ischemic stroke

Zhao, Huan; Yang, Dongdong; Shi, Min; Liang, Jingtao; Yang, Xiao; Jin, Shuoguo

doi:10.1016/s0254-6272(14)60068-6

Cited by 21 publications

(27 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirty-seven trials reported the level of consciousness (according to GCS) before treatment [20–23, 25, 27–30, 32–58], and GCS score was used in 28 studies as the outcome measure [20–23, 25, 27–30, 32, 33, 35–39, 41, 42, 44–48, 54–56, 58]. Twenty-two studies used continuous data, and the statistic used was the difference in GCS score before and after treatment [20, 21, 23, 27–30, 32, 33, 36–39, 41, 42, 44–46, 48, 54, 55]. The GCS results showed high heterogeneity ( I 2 =72%), so we did a subgroup analysis according to the treatment duration, TBI's degree (we define the GCS score between 3 and 8 as severe TBI, 8 and 12 as moderate TBI, and 13 and 15 as mild TBI), and intervention.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Tan

Zeng

Wang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Traumatic brain injury (TBI) has become an economic and social burden for patients and their families. While acupuncture is an effective tool for promoting recovery of disorder of consciousness (DOC) following TBI, there have been no comprehensive meta-analyses and/or systematic reviews addressing this topic. The present systematic review and meta-analysis aimed to assess the therapeutic efficacy of acupuncture for DOC after TBI. All randomized controlled trials (RCTs) incorporating acupuncture, or acupuncture combined with other interventions for DOC after TBI, were included and assessed by two independent investigators. Six outcome indicators were assessed: Glasgow Coma Scale (GCS); Glasgow Outcome Scale (GOS); mortality; efficacy rate; activities of daily living (ADL); and functional comprehensive assessment. Direct comparisons were performed using RevMan 5.3.0 software, with results presented as mean difference (MD) for continuous outcomes and relative risk (RR) for binary outcomes. A total of 3511 patients from 49 trials were included. Pooled analyses indicated that acupuncture may have a superior effect on GCS score (MD=2.03, 95% CI :1.92 2.43, Z=16.54, and P<0.00001); GOS score (RR=1.23, 95%CI: 1.18 1.35, Z=6.65, and P<0.00001); efficacy rate (RR=1.48, 95%CI: 1.40 1.56, Z=13.49, and P<0.00001); ADL (MD=9.20, 95% CI:8.19 10.21, Z=17.84, and P<0.00001); and mortality (RR=0.50, 95% CI:0.38 0.67, Z=4.70, and P<0.00001). The results demonstrated that the acupuncture group fared better than the control group in the treatment of DOC after TBI. However, studies were generally of poor quality, and publication bias favoring positive studies was obvious. Therefore, rigorous evaluation standards and well-designed studies are necessary in future studies.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The GOS was used in 28 trials, 25 of which used dichotomous data [22, 25, 31, 33–35, 40, 43, 45, 49–53, 57–66], and 2 were excluded because outcome times were unclear [50, 63]. Outcome was defined as good conscious state (GOS score ≥ 3/5) or poor (GOS score 1-2) as a simplified measure of level of consciousness outcome after TBI.…”

Section: Resultsmentioning

confidence: 99%

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Tan

Zeng

Wang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Glycyrrhiza uralensis Fisch. (Gancao)A component of BNG-1, Xiaoxuming, Gualou Guizhi, and Wen Dan Decoctions [24–27]; used to treat diabetic acute ischemic stroke [89]; liquiritin, a major constituent, enhanced the neurotrophic effect of NGF [90] , showed protection against Aβ-induced toxicity in rat cortical neurons and ischemic mice [35, 91] a Examples and references shown are selections highlighted by the authors b Buyang Huanwu, Sheng Yu, Xiaoxuming, Gualou Guizhi, and Wen Dan Decoctions, BNG-1, Hua Tan Tong Luo formula and Nao-Shuan-Tong are herbal mixtures that have been used to treat stroke patients in ChinaNeuroprotection data obtained from in vitro and animal studies are written in italics …”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats

Zhao

Chan

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundHistorically, traditional Chinese medicine has been widely used to treat stroke. Based on the theory of Chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called Post-Stroke Rehabilitation (PSR), comprising seven herbs – Astragalus membranaceus (Fisch.) Bunge, Salvia miltiorrhiza Bunge, Paeonia lactiflora Pall., Cassia obtusifolia L., Ligusticum chuanxiong Hort., Angelica sinensis (Oliv.) Diels, and Glycyrrhiza uralensis Fisch. We aim to examine the neuroprotective activity of PSR in vitro and in vivo, and to explore the underlying molecular mechanisms, to better understand its therapeutic effect and to further optimize its efficacy.MethodsPSR extract or vehicle was applied to primary rat neurons to examine their survival effects against N-methyl-d-aspartate (NMDA)-elicited excitotoxicity. Whole-cell patch-clamp recording was conducted to examine the NMDA-induced current in the presence of PSR. ERK- and CREB-activation were revealed by western blot analysis. Furthermore, PSR was tested for CRE promoter activation in neurons transfected with a luciferase reporter. The protective effect of PSR was then studied in the rat middle cerebral artery occlusion (MCAO) model. MCAO rats were either treated with PSR extract or vehicle, and their neurobehavioral deficit and cerebral infarct were evaluated. Statistical differences were analyzed by ANOVA or t-test.ResultsPSR prominently reduced the death of cultured neurons caused by NMDA excitotoxicity in a dose-dependent manner, indicating its neuroprotective property. Furthermore, PSR significantly reduced NMDA-evoked current reversibly and activated phosphorylation of ERK and CREB with distinct time courses, with the latter’s kinetics slower. PSR also triggered CRE-promoter activity as revealed by the increased expression of luciferase reporter in transfected neurons. PSR effectively reduced cerebral infarct and deficit in neurological behavior in MCAO rats when PSR decoction was administered starting either 6 days before or 6 h after onset of ischemia.ConclusionsPSR is neuroprotective both in vitro and in vivo – it protects cultured neurons against NMDA excitotoxicity, and effectively reduces ischemic injury and neurobehavioral deficit in MCAO rats in both the pre- and post-treatment regimens. The underlying neuroprotective mechanisms may involve inhibition of NMDA receptor current and activation of ERK and CREB. This study provides important preclinical data necessary for the further development of PSR for stroke treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1417-1) contains supplementary material, which is available to authorized users.

show abstract

“…Recently, more attention has been given to traditional Chinese medicine (TCM) herbal ingredients that have been used to treat inflammatory diseases (Wang et al, 2013). TCM has received more attention because of its safety and efficacy, fewer side effects, lower cost, and potential use as an adjunct to Western medicine (Zhao et al, 2014). Providing a molecular basis for active ingredients found in herbal medicines further enhances their use in the treatment of serious conditions and diseases associated with chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells

Park

Vick

Gao

et al. 2016

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

Clinical efficacy and safety of Traditional Chinese Medicine combined with Western Medicine in patients with diabetic acute ischemic stroke

Cited by 21 publications

References 3 publications

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats

Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells

Contact Info

Product

Resources

About