Clinical Efficacy and Safety of Current Interventions for Choroidal Neovascularization Associated with Rare Diseases: A Systematic Literature Review

Bennett, Natalie; John, Lokho; Likhar, N; Agrawal, R.; Amoaku, Winfried

doi:10.1007/s12325-018-0698-9

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…The wet/neovascular type affects approximately 10-15% of individuals with AMD, but accounts for approximately 90% of all cases of severe vision loss from the disease. Wet AMD is a condition characterized by choroidal neovascularization or CNV [28] where new pathogenic blood vessels grow in the choroid layer breaching the BrM and going across the sub-retinal space. Since these new blood vessels are abnormal, they tend to break, bleed, and leak fluid, damaging the macula that lifts up and pulls away from its base.…”

Section: Pathophysiology and Classification: Wet And Dry Amdmentioning

confidence: 99%

Age-related Macular Degeneration: Current Knowledge of Zinc Metalloproteinases Involvement

Liva

Cuffaro

Nuti

et al. 2019

CDT

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Background: Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. The disease is characterized by photoreceptor loss in the macula and reduced Retinal Pigment Epithelium (RPE) function, associated with matrix degradation, cell proliferation, neovascularization and inflammation. Matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) play a critical role in the physiology of extracellular matrix (ECM) turnover and, in turn, in ECM pathologies, such as AMD. A balance between the activities of MMPs and Tissue Inhibitors of Metalloproteinase (TIMPs) is crucial for the integrity of the ECM components; indeed, a dysregulation in the ratio of these factors produces profound changes in the ECM, including thickening and deposit formation, which eventually might lead to AMD development. Objective: This article reviews the relevance and impact of zinc metalloproteinases on the development of AMD and their roles as biomarkers and/or therapeutic targets. We illustrate some studies on several inhibitors of MMPs currently used to dissect physiological properties of MMPs. Moreover, all molecules or technologies used to control MMP and ADAM activity in AMD are analyzed. Conclusion: This study underlines the changes in the activity of MMPs expressed by RPE cells, highlights the functions of already used MMP inhibitors and consequently suggests their application as therapeutic agents for the treatment of AMD.

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Section: Pathophysiology and Classification: Wet And Dry Amdmentioning

confidence: 99%