Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction

Batista, Ana; Lins, Ruthinéia Diógenes Alves Uchôa; Coelho, Renata de Souza; Barbosa, Danielle do Nascimento; Belém, Nayara Moura; Celestino, Frayni Josley Alves

doi:10.1016/j.ctcp.2013.08.002

Cited by 48 publications

(25 citation statements)

References 18 publications

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“…As noted in this study, there was a non-significant reduction in the percentage of bleeding sites in both groups. These findings are in disagreement with those of a previous study [23] including patients diagnosed with gingivitis or chronic periodontitis. The authors observed an effective reduction in the percentage of bleeding sites in subjects that used P. granatum extract for 15 days.…”

Section: Discussioncontrasting

confidence: 57%

A Randomized, Controlled Clinical Trial on the Clinical and Microbiological Efficacy of Punica granatum Linn Mouthwash

Nóbrega¹,

Santos²,

Soares³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the clinical efficacy of a mouthwash containing Punica granatum L as compared to 0.12% chlorhexidine digluconate on the control of dental biofilm and gingival inflammation. Material and Methods: A randomized, controlled, double-blind clinical trial was carried out comprising a sample of 35 students aged nine to twelve years having Simplified Oral Hygiene Index value equal to or higher than 1.6, with at least 20 teeth. The sample was divided into two groups: group A, administration of 0.12% chlorhexidine mouthwash twice a day for 14 days; and group B, administration of Punica granatum mouthwash (6.25%) following the same protocol described above. The Plaque Index (PI) and Bleeding on Probing Index (BPI) were used to evaluate biofilm control and gingival inflammation on days 0, 7 and 14. Counting of oral streptococci from saliva samples was also performed on days 0 and 14. The data were analyzed using Student"s t test and Analysis of Variance (ANOVA). Results: The findings showed that P. granatum mouthwash reduced the mean values of PI and BPI, but with no significant difference. However, there was a significant reduction in the counting of oral streptococci. In the control group, all variables were found to be significantly reduced. Conclusion: Punica granatum mouthwash was not effective for the control of dental biofilm and gingival inflammation, but it was effective in reducing the counting of oral streptococci.

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Section: Discussioncontrasting

confidence: 57%

A Randomized, Controlled Clinical Trial on the Clinical and Microbiological Efficacy of Punica granatum Linn Mouthwash

Nóbrega¹,

Santos²,

Soares³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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“…10,11 In oral cavity P. granatum extract has positive therapeutic effect in reducing gingival bleeding in periodontal disease), recurrent aphthous stomatitis. 12,13 Our results indicate that all the 4 different solvent systems examined in the present investigation were very effective and exerted a wide spectrum antimicrobial property. Among the 8 species examined Streptococcus salivarius MTCC 1938, Streptococcus mitis MTCC 2695 and Staphylococcus epidermidis MTCC 435 were only resistant and did not show any inhibitory activity.…”

Section: Discussionmentioning

confidence: 56%

Evaluation of Antimicrobial Property of Extract of Punica Granatum (L.) on Oral Pathogens

K¹,

2022

Int J Life Sci Pharm Res

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The aim of the present research was the examination of the potential activity of various organic solvent extracts of Punica granatum on the important microbiota harbouring in the oral cavity. The dried peels and seeds of P. granatum were extracted using chloroform, methanol and nbutanol and their potential activity were studied. The inhibitory effect of crude extracts were observed on various microbial plates which were incubated with different bacterial species in terms of zone of inhibition as mm in diameter. The data was analysed by One Way Analysis of Variance for significance. The peel extract was more potent in inhibiting the microbial population growth as compared to seed extract. While all the four solvents were effective in case of peel extracts, the bioactivity was much higher in species such as Streptococcus mutants, Streptococcus sanguis, Staphylococcus aureus, Lactobacillus acidophilus and Actinomyces viscosus, among 8 species evaluated in the present investigation. The peel extract of P. granatum contains active biomolecule(s) against important oral microbial pathogens and thus holds promise as a potential bioactive molecule against Dental Caries. Based on the bioactivity analysis, the peel extract of P. granatum may further be subjected to purification and characterization of the bioactive compound(s) for regulating oral microbial contamination.

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“…It is also important to highlight that with 1% essential oil of P. heptaphyllum, the components of the oil will be diluted in a concentration similar to a commercial mouthwash such as listerine (menthol 0.042%, thymol 0.064%, methyl salicylate 0.06% and eucalyptol 0.092%) (Pan et al, 2010;Oyanagi et al, 2012). There are some studies about essential oils mouthwash, several using a 0.2 to 1.4% concentration of essential oil (Kothiwale et al, 2014;Lobo et al, 2014;Quintas et al, 2014) and others in which the final concentration is omitted (Batista et al, 2014). An antiseptic agent to be used in children should not be harmful to the mucosa; its toxicity should be low if ingested accidentally, and it should be free from sugar and alcohol (Subramanian and Nandan, 2011).…”

Section: Discussionmentioning

confidence: 99%

Stability and disinfecting proprieties of the toothbrush rinse of the essential oil of Protium heptaphyllum

Fernanda¹,

Otavio²,

Mirian³

et al. 2015

Afr. J. Pharm. Pharmacol.

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Protium heptaphyllum (PH) is rich in essential oil, has anti-inflammatory properties and has no toxic potential. However, data is unavailable about its antiseptic effect against bacteria that cause caries. This study aimed to evaluate the antiseptic effect of the toothbrush rinse of essential oil of PH as well as its chemical stability. The toothbrush rinse was prepared with 1% essential oil of PH. The minimum inhibitory concentration (MIC) of the essential oil and toothbrush rinse were evaluated against Streptococcus mutans (ATCC 25175™). The ex vivo study was double-blinded and randomised; the children were divided into three groups, each participating in a crossover design where all solutions (water, toothbrush rinse (1%) and chlorhexidine (0.12%) were used in all stages by different groups of children. The chemical composition of the essential oil and toothbrush rinse were analysed by gas chromatography coupled to mass spectrometry. The stability was evaluated at three time points. The essential oil and toothbrush rinse exhibited antimicrobial activity against S. mutans, MIC = 0.125 and 2.4 µg/ml. The toothbrush rinse showed the same effect as chlorhexidine on disinfecting the toothbrushes contaminated with mutans streptococci (pH = 57.3 ± 5.3%; chlorhexidine 55.5 ± 13.3%; water 39.4 ± 5.8%; p > 0.05). Chromatographic analysis showed that the essential oil contained monoterpenes as a major component, and the toothbrush rinse possessed the same constituents as the pure essential oil, except for α-terpineol. Storage did not cause chemical degradation of the toothbrush rinse, but decreased the concentration of the chemical constituents. The toothbrush rinse of essential oil of P. heptaphyllum showed antiseptic properties and exhibited antimicrobial activity against mutans streptococci.

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Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction

Cited by 48 publications

References 18 publications

A Randomized, Controlled Clinical Trial on the Clinical and Microbiological Efficacy of Punica granatum Linn Mouthwash

A Randomized, Controlled Clinical Trial on the Clinical and Microbiological Efficacy of Punica granatum Linn Mouthwash

Evaluation of Antimicrobial Property of Extract of Punica Granatum (L.) on Oral Pathogens

Stability and disinfecting proprieties of the toothbrush rinse of the essential oil of Protium heptaphyllum

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