“…Three CTs were randomized single-blind, controlled, and with parallel design [ 11 , 12 , 17 ]. Three CTs were randomized unblinded, controlled, and with parallel design [ 14 – 16 ], one CT was randomized unblinded, controlled, and with split-mouth design [ 13 ], and one CT was quasi-randomized, controlled, with parallel design [ 5 ]. One CT compared 4 groups [ 14 ], 2 CTs compared 3 groups [ 11 , 12 ], and 5 CTs compared 2 groups [ 5 , 13 , 15 – 17 ].…”