Clinical effects of perazine ferulate tablets combined with eucalyptol limonene pinene enteric soft capsules for treatment of children with IgA nephropathy

Liu, Zhizhen; Pan, Jingmei; Sun, Chunlei; Zhou, Juan; Li, N A

doi:10.3892/etm.2016.3312

Cited by 11 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Piperazine ferulate tablets combined with eucalyptol, limonene, and pinene enteric soft capsules were used for IgA nephropathic children therapy by Liu et al [82]. In the observation group, patients were treated with piperazine ferulate tablets (0.1 g/dose and 3 times/day) combined with eucalyptol, limonene, and pinene enteric soft capsules (0.1 g/dose and 2 times/day) for 6 months.…”

Section: Preclinical Pharmacological Activities Of α- and β-Pinenementioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

et al. 2019

View full text Add to dashboard Cite

α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

show abstract

Section: Preclinical Pharmacological Activities Of α- and β-Pinenementioning

confidence: 99%

“…The effective rate of observational group (12 patients) was significantly higher when compared with hormone group (18 patients). Differences between serum IgA, fibronectin, and complement C3 of two selected groups were not statistically significant [82].…”

Section: Preclinical Pharmacological Activities Of α- and β-Pinenementioning

confidence: 99%

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Piperazine ferulate (Piperazine 3-methoxy-4-hydroxycinnamate; PF; Fig. 1A ) is a derivative of ferulic acid that exhibits anti-hypertensive effects ( 14 ), reduces IgA-mediated nephropathy ( 15 ) and prevents the development of DN ( 16 ). A systematic meta-analysis indicated that PF combined with irbesartan could improve the efficiency of treatment of DN ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Piperazine ferulate prevents high‑glucose‑induced filtration barrier injury of glomerular endothelial cells

et al. 2021

View full text Add to dashboard Cite

Filtration barrier injury induced by high glucose (HG) levels leads to the development of diabetic nephropathy. The endothelial glycocalyx plays a critical role in glomerular barrier function. In the present study, the effects of piperazine ferulate (PF) on HG-induced filtration barrier injury of glomerular endothelial cells (GEnCs) were investigated and the underlying mechanism was assessed. Immunofluorescence was used to observe the distribution of the glycocalyx as well as the expression levels of syndecan-1 and Zonula occludens-1 (ZO-1). Endothelial permeability assays were performed to assess the effects of PF on the integrity of the filtration barrier. Protein and mRNA expression levels were measured by western blotting and reverse transcription-quantitative PCR analyses, respectively. In vitro experiments revealed that adenosine monophosphate-activated protein kinase (AMPK) mediated HG-induced glycocalyx degradation and endothelial barrier injury. PF inhibited the HG-induced endothelial barrier injury and restored the expression levels of heparanase-1 (Hpa-1), ZO-1 and occludin-1 by AMPK. In vivo assays demonstrated that PF reduced the expression levels of Hpa-1, increased the expression levels of ZO-1 and attenuated glycocalyx degradation in the glomerulus. These data suggested that PF attenuated HG-induced filtration barrier injury of GEnC by regulating AMPK expression.

show abstract

“…Piperazine ferulate (PF; C 4 H 10 N 2 •2C 10 H 10 O 4 ; 474.51 g/mol; Fig. 1A), a compound synthesized by ferulic acid and piperazine, is used in the treatment of various types of kidney disease including DN, nephritis (20) and immunoglobulin (Ig) A nephropathy (21) in China. Previous research has revealed that PF reduces the levels of blood urea nitrogen and serum creatinine in rats subjected to 5/6 nephrectomy (22) and exerts anti-hypertensive effects via the activation of endothelial nitric oxide synthase (eNOS) (23).…”

Section: Introductionmentioning

confidence: 99%

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66^Shc

et al. 2021

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes. Hyperglycemia-induced glomerular mesangial cells injury is associated with microvascular damage, which is an important step in the development of DN. Piperazine ferulate (PF) has been reported to exert protective effects against the progression of DN. However, whether PF prevents high glucose (HG)-induced mesangial cell injury remains unknown. The aim of the present study was to investigate the effects of PF on HG-induced mesangial cell injury and to elucidate the underlying mechanisms. Protein and mRNA expression levels were determined via western blot analysis and reverse transcription-quantitative PCR, respectively. IL-6 and TNF-α levels were measured using ELISA. Reactive oxygen species levels and NF-κB p65 nuclear translation were determined via immunofluorescence analysis. Apoptosis was assessed by measuring lactate dehydrogenase (LDH) release, as well as using MTT and flow cytometric assays. The mitochondrial membrane potential of mesangial cells was determined using the JC-1 kit. The results revealed that LDH release were increased; however, cell viability and mitochondrial membrane potential were decreased in the HG group compared with the control group. These changes were inhibited after the mesangial cells were treated with PF. Moreover, PF significantly inhibited the HG-induced production of inflammatory cytokines and the activation of NF-κB in mesangial cells. PF also attenuated the HG-induced upregulation of the expression levels of fibronectin and collagen 4A1. Furthermore, the overexpression of p66 Src homology/collagen (Shc) abolished the protective effect of PF on HG-induced mesangial cell injury. In vivo experiments revealed that PF inhibited the activation of inflammatory signaling pathways, glomerular cell apoptosis and mesangial matrix expansion in diabetic mice. Collectively, the present findings demonstrated that PF attenuated HG-induced mesangial cells injury by inhibiting p66 Shc .

show abstract

Clinical effects of perazine ferulate tablets combined with eucalyptol limonene pinene enteric soft capsules for treatment of children with IgA nephropathy

Cited by 11 publications

References 14 publications

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Piperazine ferulate prevents high‑glucose‑induced filtration barrier injury of glomerular endothelial cells

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66^Shc

Contact Info

Product

Resources

About

Clinical effects of perazine ferulate tablets combined with eucalyptol limonene pinene enteric soft capsules for treatment of children with IgA nephropathy

Cited by 11 publications

References 14 publications

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Piperazine ferulate prevents high‑glucose‑induced filtration barrier injury of glomerular endothelial cells

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66Shc

Contact Info

Product

Resources

About

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66^Shc