Chronic diseases of the cardiovascular system, including coronary heart disease (CHD) and hypertension, are leading causes of morbidity and mortality in the United States and other Western countries. Many physiological, environmental, and behavioral variables interact in the development of these disorders. This chapter reviews recent epidemiological findings in the field, including a description of standard risk factors, and evidence for the effects and impact of psychosocial and demographic risk factors, including race, sex, and stress. In addition, we examine the role of individual characteristics such as Type A behavior, anger/hostility, and depression in the development of CHD. Issues such as personality, salt intake, and obesity all impact the development of hypertension. The benefits of conventional treatments, including medical and surgical options, cardiac rehabilitation, and weight loss/dietary restrictions, are described, as are newer and less conventional treatments such as major lifestyle changes, increased social support, and cognitive‐behavioral approaches. This chapter highlights the need for additional research in the areas of CHD/hypertension prevention and treatment by medical professionals and health psychologists alike.