Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial

Park, Dae Hyun; Chung, Jung Kee; Seo, Du Ri; Lee, Sung‐Jin

doi:10.1016/j.ajo.2015.12.002

Cited by 42 publications

(50 citation statements)

References 33 publications

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“…All studies provided specified criteria for the diagnosis of dry eye. Three studies evaluated the efficacy of diquafosol in dry eye populations after cataract surgery [11, 16, 19]. …”

Section: Resultsmentioning

confidence: 99%

“…In 5 of the studies, topical 3% diquafosol was compared with sodium hyaluronate eye drops [12-14, 16, 18]. Two studies compared 3% diquafosol with preservative-free artificial tears [17, 19].…”

Section: Resultsmentioning

confidence: 99%

“…One study examined 0.9% normal saline [11] and 1 study used placebo eye drops [15]. Topical 3% diquafosol was prescribed 4 times daily [11, 13] or 6 times daily [12, 14-16, 18]. …”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Topical 3% Diquafosol Ophthalmic Solution for the Treatment of Multifactorial Dry Eye Disease: Meta-Analysis of Randomized Clinical Trials

Nam

Kim

Yoo³

2019

Ophthalmic Res

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Purpose: A meta-analysis was performed to evaluate the safety and efficacy of topical 3% diquafosol in treating patients with dry eye disease (DED). Methods: Nine qualified randomized controlled trials incorporating 1,467 patients were included. Two of the reviewers selected the studies and independently assessed the risk of bias. The outcome measures were Schirmer score, tear film break-up time (TFBUT), rose bengal staining score, and corneal fluorescein staining score. To confirm the effect of diquafosol on dryness after cataract surgery, we performed a subgroup analysis according to the presence or absence of surgery. Results: We observed statistically significant improvements in scores on the Schirmer test (weighted mean difference 0.74 mm at 4 weeks; 95% CI: 0.24–1.24; I² = 0%), fluorescein stain, rose bengal stain, and TFBUT after treatment with diquafosol compared with the group using other eye drops. As a result of the subgroup analysis of DED after cataract surgery, diquafosol was found to be more effective than the other eye drops with regard to TFBUT and rose bengal staining. Conclusions: Topical diquafosol could be an effective treatment for DED, and also for DED after cataract surgery. Further randomized controlled trials with larger sample sizes for the different clinical types of DED are warranted to determine the efficacy and limitations of diquafosol for these different clinical types of DED.

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“…All studies provided specified criteria for the diagnosis of dry eye. Three studies evaluated the efficacy of diquafosol in dry eye populations after cataract surgery [11, 16, 19]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and Safety of Topical 3% Diquafosol Ophthalmic Solution for the Treatment of Multifactorial Dry Eye Disease: Meta-Analysis of Randomized Clinical Trials

Nam

Kim

Yoo³

2019

Ophthalmic Res

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“…In dry eye after cataract surgery, as well, it was reported that the treatment with ophthalmic solutions including DQS was effective 7–9. Although effectiveness of DQS treatment on HOAs in dry eye has been reported, there is not enough evidence, especially in cataract surgery-induced dry eye.…”

Section: Introductionmentioning

confidence: 99%

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

Inoue¹,

Ochi²

2016

OPTH

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PurposeTo evaluate the effects of diquafosol sodium ophthalmic solution 3% (DQS) and artificial tears (AT) on higher-order aberrations (HOAs) in patients with dry eye after cataract surgery.DesignThis was a post hoc analysis of a previously conducted randomized clinical study.MethodsFifty-nine eyes from 42 patients (17 males and 25 females, aged 72.6±8.0 years) with verified or suspected dry eye at 4 weeks after cataract surgery were evaluated. The dry eye patients were randomly assigned to receive DQS or AT for 4 weeks. Tear breakup time (BUT), corneal and conjunctival fluorescein staining scores, and HOAs were analyzed before and after instillation. HOAs were measured consecutively for 10 seconds with a wavefront analyzer. Average HOAs, HOA fluctuations (fluctuation index [FI]) and changes in HOAs (stability index [SI]) were compared within and between the two groups.ResultsAfter 4 weeks of instillation, BUT significantly increased (P=0.001) compared with preinstillation values in the DQS group, but not in the AT group. This increase in BUT in the DQS group was significantly greater than in the AT group (P=0.014). Corneal and conjunctival fluorescein staining scores after instillation significantly improved compared with preinstillation values in the DQS group (P=0.018). In HOAs, the cornea aberration changed from an upward curve (a sawtooth pattern) to an almost constant value (a stable pattern) in the DQS group, but not in the AT group. In FI and SI, there were no significant changes in either group; however, FI and SI were significantly lower in the DQS group than in the AT group (both, P=0.004).ConclusionThe dry eye patients after cataract surgery had a visual dysfunction in HOAs. DQS is effective to treat dry eye disease after cataract surgery with improvement of visual function.

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“…In recent years, diquafosol has been used for treating different conditions related with dry eye (Table 2). This dinucleotide improves the tear secretion and symptomatology in Sj€ ogren syndrome (Bremond-Gignac et al, 2014;Yokoi et al, 2015), aqueous deficient dry eye (Koh et al, 2013a(Koh et al, , 2014, contact lens wearers (Nagahara et al, 2015), Meibomian gland dysfunction (Arita et al, 2013;Yamaguchi et al, 2015), dry eye related with cataract surgery (Miyake et al, 2014;Park et al, 2015), even in normal eyes (Gendaszewska-Darmach and Kucharska, 2011;Nam et al, 2015;Yokoi et al, 2014). Regarding the safe use of diquafosol, the majority of adverse reactions, found in different clinical trials, were of mild severity, and no serious treatment-related adverse events were reported.…”

Section: Effect On Tear Secretionmentioning

confidence: 99%

The role of dinucleoside polyphosphates on the ocular surface and other eye structures

Carracedo

Crooke

Guzmán-Aránguez

et al. 2016

Progress in Retinal and Eye Research

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a b s t r a c tDinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present in tears, aqueous humour and in the retina. As the consequence of their presence, these dinucleotides contribute to many ocular physiological processes. On the ocular surface, dinucleoside polyphosphates can stimulate tear secretion, mucin release from goblet cells and they help epithelial wound healing by accelerating cell migration rate. These dinucleotides can also stimulate the presence of proteins known to protect the ocular surface against microorganisms, such as lysozyme and lactoferrin. One of the latest discoveries is the ability of some dinucleotides to facilitate the paracellular way on the cornea, therefore allowing the delivery of compounds, such as antiglaucomatous ones, more easily within the eye. The compound Ap 4 A has been described being abnormally elevated in patient's tears suffering of dry eye, Sjogren syndrome, congenital aniridia, or after refractive surgery, suggesting this molecule as biomarker for dry eye condition. At the intraocular level, some diadenosine polyphosphates are abnormally elevated in glaucoma patients, and this can be related to the stimulation of a P2Y 2 receptor that increases the chloride efflux and water movement in the ciliary epithelium. In the retina, the dinucleotide dCp 4 U, has been proven to be useful to help in the recovery of retinal detachments. Altogether, dinucleoside polyphosphates are a group of compounds which present relevant physiological actions but which also can perform promising therapeutic benefits.

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Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients With Dry Eye After Cataract Surgery: A Randomized Controlled Trial

Cited by 42 publications

References 33 publications

Efficacy and Safety of Topical 3% Diquafosol Ophthalmic Solution for the Treatment of Multifactorial Dry Eye Disease: Meta-Analysis of Randomized Clinical Trials

Efficacy and Safety of Topical 3% Diquafosol Ophthalmic Solution for the Treatment of Multifactorial Dry Eye Disease: Meta-Analysis of Randomized Clinical Trials

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

The role of dinucleoside polyphosphates on the ocular surface and other eye structures

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