Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Mousavi, Seyed Mohammad; Hajishafiee, Maryam; Clark, Cain C. T.; Nascimento, Israel Júnior Borges do; Milajerdi, Alireza; Amini, Mohammad Reza; Esmaillzadeh, Ahmad

doi:10.1016/j.phrs.2020.105166

Cited by 13 publications

(18 citation statements)

References 64 publications

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“…A large category of cytokines, including IL-4, IL-6, interferon-g (IFN-g), TNF-α from innate immunity ( 82 ), and IL-2, TNF, and IFN-γ from adaptive immunity ( 82 , 83 ) were found to be inhibited in production in patients with zinc deficiency. Most of the cytokines mentioned were also in the participation of inflammation and oxidative stress ( 84 , 85 ). A higher dose of zinc supplementations in adults could increase serum total antioxidant capacity (MD: 225.9 μmmol/L; 95% CI: 68.42, 383.5) ( 85 ) and glutathione (MD: 49.99 μmmol/L; 95% CI: 2.25, 97.73) ( 85 ), decrease malondialdehyde (ES: −0.42 nmol/ml, 95% CI: −0.83, −0.01) ( 43 )and TNF-α (ES: −0.49 pg/mL, 95% CI: −0.84, −0.14) ( 43 ) and CRP (ES: −0.92 mg/L, 95% CI: −1.36, −0.48) ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

“…After binding to superoxide dismutase, zinc could also transform superoxide anion radicals into hydrogen peroxide (85). Other mechanisms to reduce oxidative stress and inflammation by zinc are as followed: stabilizing the cell membrane structure (43,89,90); suppressing the activity of NADPH (nicotinamide adenine dinucleotide phosphate) oxidase from producing superoxide anion radical (43,91); down-regulating NF-κB which was activated by peroxisome proliferator-activated receptor-α to produce fewer cytokines (44); sustaining enough MTs to eliminate free radicals (72) and protecting the function of thiols (85,91). Under these circumstances, it made sense that sperm concentration, morphology and volume and clinical pregnancy rate would see a rise when adults were heavily dosed (49)(50)(51).…”

Section: Main Findings and Possible Explanationsmentioning

confidence: 99%

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Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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It is widely accepted that the zinc element is crucial in human beings. Zinc has gained more attention during the COVID-19 pandemic due to its utilization for the treatment and prevention of respiratory tract infections. However, some studies also pointed out that zinc intake might cause unwanted side effects and even be dangerous when overdosed. To reveal the relationship between zinc intake and health outcomes, we performed an umbrella review from human studies. In total, the umbrella review included 43 articles and identified 11 outcomes for dietary zinc intake and 86 outcomes for supplementary zinc intake. Dietary zinc intake in the highest dose would decrease the risk of overall and specific digestive tract cancers, depression, and type 2 diabetes mellitus (T2DM) in adults. Supplementary zinc consumption in adults was linked to an improvement of depression, antioxidant capacity and sperm quality, higher serum zinc concentration, and lower concentration of inflammatory markers. Zinc supplementation in children would reduce the incidence of diarrhea and pneumonia, improve zinc deficiency and boost growth. However, zinc might not decrease all-cause mortality in adults or the in-hospital mortality of COVID-19. And better maternal and neonatal outcomes may not derive from pregnant women who consumed higher or lower doses of zinc supplementation (>20 mg/day and <20 mg/day, respectively). Dose-response analyses revealed that a daily 5 mg increment of zinc would lower the risk of colorectal and esophageal cancer, whereas a large dose of zinc supplementation (daily 100 mg) showed no benefit in reducing prostate cancer risk.

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Section: Discussionmentioning

confidence: 99%

Section: Main Findings and Possible Explanationsmentioning

confidence: 99%

Zinc Intakes and Health Outcomes: An Umbrella Review

Cao

Huang

et al. 2022

Front. Nutr.

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“…Furthermore, the other components of Trophogast pellet may have played a significant role in the efficacy observed. Zinc is reported to have an essential role in maintaining redox balance and protecting against oxidative stress, [36][37][38] and in controlling inflammatory reactions. 37,48 In horses affected by ESGD, chelated minerals containing zinc have been studied 49 ; in particular, in one recent study zinc-methionine proved to be beneficial in reducing ESGD scores after omeprazole treatment.…”

Section: Discussionmentioning

confidence: 99%

“…may provide an additional benefit due to their antioxidant properties, protecting the mucosa against the generation of damaging oxygen free radicals. [34][35][36][37][38][39] This study aims to investigate the efficacy of Trophogast pellet, administered for 30 days, for the treatment of spontaneously occurring ESGD in endurance horses in training.…”

Section: Introductionmentioning

confidence: 99%

Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

et al. 2021

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Introduction: Equine squamous gastric disease (ESGD) may require prolonged treatments with acid suppressants; therefore, interest in nutraceutical supplements with anti-ulcerogenic properties has increased. This study aims to investigate the efficacy of Trophogast pellet for the treatment of ESGD in endurance horses. Material and methods: Fifteen endurance horses were included based on their gastroscopic examination and randomly assigned to a treatment group, receiving Trophogast pellet for 30 days together with management changes, or to a control group, only subjected to management modifications. At the end of treatment, gastroscopy was repeated. Scores were assigned according to the Equine Gastric Ulcer Council scoring system. All horses were weighed at the beginning and at the end of the study. ESGD grades and weight before and after treatment were compared. Results: At enrolment, median ESGD score in the treatment group was 2, while in the control group it was 1. After the treatment period, a significant decrease in ESGD grade was observed in the treatment group (median 1, p = 0.0078), while there was no change in the control group (median 2). No significant weight change was observed in either group. Conclusion: Trophogast pellet was effective at promoting healing of mild ESGD in endurance horses.

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“…Previous evidence has found that most of the beneficial effects of zinc are attributed to its antioxidative function [17][18][19]. Zinc deficiency enhances the imbalance of redox, which leads to deterioration and oxidative damage [20].…”

Section: Introductionmentioning

confidence: 99%

Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway

Liu

Jin

et al. 2021

Journal of Diabetes Research

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Zinc is an essential trace element that is often reduced under the type 1 diabetic condition. Previous studies demonstrated that zinc deficiency enhanced type 1 diabetes-induced liver injury and that zinc supplementation significantly helped to prevent this. Due to the differences in pathogenesis between type 1 and type 2 diabetes, it is unknown whether zinc supplementation can induce a beneficial effect on type 2 diabetes-induced liver injury. This possible protective mechanism was investigated in the present study. A high-fat diet, along with a one-time dose of streptozotocin, was applied to metallothionein (MT) knockout mice, nuclear factor-erythroid 2-related factor (Nrf) 2 knockout mice, and age-matched wild-type (WT) control mice, in order to induce type 2 diabetes. This was followed by zinc treatment at 5 mg/kg body weight given every other day for 3 months. Global metabolic disorders of both glucose and lipids were unaffected by zinc supplementation. This induced preventive effects on conditions caused by type 2 diabetes like oxidative stress, apoptosis, the subsequent hepatic inflammatory response, fibrosis, hypertrophy, and hepatic dysfunction. Additionally, we also observed that type 2 diabetes reduced hepatic MT expression, while zinc supplementation induced hepatic MT expression. This is a crucial antioxidant. A mechanistic study showed that MT deficiency blocked zinc supplementation-induced hepatic protection under the condition of type 2 diabetes. This suggested that endogenous MT is involved in the hepatic protection of zinc supplementation in type 2 diabetic mice. Furthermore, zinc supplementation-induced hepatic MT increase was unobserved once Nrf2 was deficient, indicating that Nrf2 mediated the upregulation of hepatic MT in response to zinc supplementation. Results of this study indicated that zinc supplementation prevented type 2 diabetes-induced liver injury through the activation of the Nrf2-MT-mediated antioxidative pathway.

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Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Cited by 13 publications

References 64 publications

Zinc Intakes and Health Outcomes: An Umbrella Review

Zinc Intakes and Health Outcomes: An Umbrella Review

Effects of a nutraceutical supplement in the management of mild equine squamous gastric disease in endurance horses

Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway

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