2023
DOI: 10.7759/cureus.37833
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Clinical Effectiveness of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Adult Obsessive-Compulsive Disorder (OCD) Treatment: A Systematic Review

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Cited by 2 publications
(1 citation statement)
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“…The most established evidence-based psychotherapeutic treatment is cognitive behavioural therapy (CBT) with exposure and response prevention (ERP), whereby the patient is deliberately exposed to OCD symptom-provoking situations, whilst refraining from engaging in compulsive behaviours ( 2 , 3 ). Despite the efficacy of these first-line treatment options in many patients, there is still a considerable proportion (estimated ~30%) of people whose OCD symptoms do not improve significantly over time despite adequate treatment ( 4 6 ). Such difficult-to-treat cases of OCD can be exceptionally challenging in clinical practice and there is an urgent need for novel interventions that can be offered to affected patients.…”
Section: Introductionmentioning
confidence: 99%
“…The most established evidence-based psychotherapeutic treatment is cognitive behavioural therapy (CBT) with exposure and response prevention (ERP), whereby the patient is deliberately exposed to OCD symptom-provoking situations, whilst refraining from engaging in compulsive behaviours ( 2 , 3 ). Despite the efficacy of these first-line treatment options in many patients, there is still a considerable proportion (estimated ~30%) of people whose OCD symptoms do not improve significantly over time despite adequate treatment ( 4 6 ). Such difficult-to-treat cases of OCD can be exceptionally challenging in clinical practice and there is an urgent need for novel interventions that can be offered to affected patients.…”
Section: Introductionmentioning
confidence: 99%