Clinical Effectiveness of Influenza Vaccination in Manitoba

Fedson, David S.; Wajda, André; Nicol, James; Hammond, Greg; Kaiser, Donald L.; Roos, Leslie L.

doi:10.1001/jama.1993.03510160074032

Cited by 211 publications

(92 citation statements)

References 32 publications

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“…Doubts have been expressed about the protection offered by influenza vaccination in the elderly, particularly in those with conditions that put them at high risk of the complications of influenza [7,8]. This study supports the suggestion from earlier studies conducted in nursing homes [9], and more recent studies on the elderly in the community [10][11][12][13][14]. that influenza immunization provides a valuable degree of protection against the severe complications of influenza.…”

Section: Discussionsupporting

confidence: 83%

Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989–90 using a general practice database

Fleming

Watson²,

Nicholas³

et al. 1995

Epidemiol. Infect.

105

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SUMMARYThe effectiveness of influenza vaccination in preventing serious illness and death was determined in an elderly population during the influenza epidemic of 1989-90. A retrospective cohort study was carried out using computerized general practitioner records on nearly 10000 patients aged 55 years and over. After adjustment for potential confounding factors, recent immunization was found to have a protective effect of 75% (95% confidence intervals: 21-92%) against death. Protection did not appear to vary with either age or the presence of underlying chronic disease. As the complications of influenza are most common in those with underlying chronic disease, the study findings are consistent with the recommended policy for the use of influenza vaccine in the UK. Further work is necessary to determine the cost-effectiveness of extending immunization to other groups.

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Section: Discussionsupporting

confidence: 83%

Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989–90 using a general practice database

Fleming

Watson²,

Nicholas³

et al. 1995

Epidemiol. Infect.

105

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show abstract

“…40 A case-control study in persons 45 years or older suggested a 30% reduction in death due to all causes. 41 Vaccination of health workers caring for the elderly population residing in nursing homes has been associated with up to a 50% reduction in mortality of the elderly. 42 In a meta-analysis of 20 cohort studies, influenza vaccination led to a 68% reduction in death; vaccine efficacy in the case-control studies was Ϸ30% for preventing deaths due to all causes.…”

Section: Influenza Vaccination and All-cause Mortalitymentioning

confidence: 99%

Influenza and Cardiovascular Disease

Madjid¹,

Naghavi²,

Litovsky³

et al. 2003

Circulation

161

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“…These symptoms are frequently experienced in association with a host of other viral infections. [4][5][6][7][8][9][10][11][12][13][14][15][16] Few of these studies document actual influenza viral infection by using direct fluorescence antibody testing, polymerase chain reaction (PCR) analysis and cell culture techniques to isolate and identify the virus.…”

mentioning

confidence: 99%