Clinical Effectiveness of Anorganic Bovine-Derived Hydroxyapatite Matrix/Cell-Binding Peptide Grafts for Regeneration of Periodontal Defects: A Systematic Review and Meta-Analysis

Abstract

Aim: To ascertain clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (ABM/P-15) for regeneration of periodontal defects. Materials & methods: Electronic databases (National Library of Medicine [Medline by PubMed], Cochrane Library [Wiley], CINAHL [EBSCO] and Medline [EBSCO]) were systematically searched up to December 2019. Randomized controlled clinical trials comparing ABM/P-15 grafts to conventional surgery for intrabony and gingival recession defects were included and evaluated intrabony defects including clinical attachment level (CAL), probing depth and gingival recession. Results: A significant gain in CAL (1.37 mm), and reduction in probing depth (1.22 mm) were shown by ABM/P-15 grafts than open flap debridement (p < 0.00001). The subgroup analysis also showed better results for ABM/P-15 grafts in CAL gain for intrabony defects. For furcation and gingival recession defects, no significant difference was seen. Conclusion: The adjunct use of ABM/P-15 grafts in conventional periodontal surgery is useful for periodontal regeneration of intrabony defects.

Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis

“…The overall meta-analysis showed no additional benefits of NcHA over other BGs, demonstrating comparable results of CAL gain, PPD reduction and REC increase between both test (NcHA) and control (other BGs) groups. This is in disagreement with a systematic review that demonstrated beneficial effects of a BG (anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide graft) rather than the OFD, in terms of CAL gain and PPD reduction [ 63 ]. However, in the subgroup analysis (NcHA versus synthetic BGs), only REC change demonstrated statistically significant results in favour of synthetic BGs, rather than NcHA grafts ( p < 0.05).…”

“…In the realm of periodontal regeneration, innovative therapies and adjuncts to established treatment methods are constantly being researched and presented [ 59 ]. Several treatment approaches for periodontal regeneration have been utilised, including barrier membranes [ 60 , 61 ], BGs [ 62 , 63 ], EMD [ 64 , 65 , 66 ], and growth factors [ 67 ]. In humans, there is considerable histological evidence of BGs, indicating periodontal unit regeneration with new cementum, alveolar bone, and a functioning periodontal ligament [ 68 ].…”

Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review

“…Research is being carried out in the field of bone regeneration for periodontal defects. Guided tissue regeneration (GTR) procedures [ 52 , 53 , 54 ], the use of enamel matrix derivatives (EMD) [ 55 , 56 , 57 , 58 ], growth factors (GF) [ 59 , 60 , 61 ], BMPs [ 62 ], platelet-rich plasma/fibrin (PRP/PRF) [ 63 , 64 , 65 ], and various bone grafting procedures [ 66 , 67 , 68 , 69 ] have been extensively described in the literature. Autogenous material obtained from the same individual is always considered the gold standard because of its high osteogenic, osteoinductive, and osteoconductive potential [ 70 ].…”

Potential of Bone-Marrow-Derived Mesenchymal Stem Cells for Maxillofacial and Periodontal Regeneration: A Narrative Review

“…However, in conventional periodontal surgery, the use of the anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (ABM/P-15) graft has a helpful effect in a therapeutic way for periodontal regeneration as well as open flap debridement (OFD) and coronally positioned flap (CPF). But, it should be compared with other regeneration techniques, and the longevity of the materials should be studied more [ 146 ].…”