Clinical effect of vitamin C supplementation on bone healing: A systematic review

Abstract

Background The aim of the present systematic review was to evaluate the clinical effect of vitamin C on bone healing after bone fracture or bone reconstruction procedures. Material and Methods In October 2020, Cochrane Library, Scopus and PubMed-Medline databases were searched without restrictions to identify animal and human studies that fulfilled the eligibility criteria. Outcome measures were bone healing time, bone gain (mm), bone density and adverse events. The risk of bias assessment of the selected studies was evaluated by means of Cochrane Collaboration’s Tool for randomized clinical trials, while randomized clinical animal trials were assessed according to SYRCLE’s tool. Additionally, quality of reporting animal studies were assessed according to ARRIVE guidelines. Results Out of the 248 articles that yielded the initial search, 11 papers about the effect of ascorbic acid on bone healing were selected. In most of the animal studies, vitamin C seemed to accelerate bone formation owing to an enhanced osteoblastic proliferation and differentiation and its antioxidant function when pro-oxidant substances were added. It was not possible to observe this phenomenon in human studies. Conclusions Although additional well-performed animal and human studies are required, vitamin C seems to accelerate bone regeneration without adverse events. However, it is not possible to recommend a specific dose or route of administration of vitamin C to improve the bone healing process in humans as there was great heterogeneity among the included studies. Key words: Vitamin C, Fracture healing, Bone regeneration, Bone mineral density, Implants.

Consumption of underutilised grain legumes and the prevention of type II diabetes and cardiometabolic diseases: Evidence from field investigation and physicochemical analyses

“…Vitamin C has a favourable impact on the spatio-temporal expression of transcripts associated with early resolution of in ammation and tissue remodelling. In addition, Barrios-Garay et al [34] have also shown from in vivo animal studies that vitamin C appears to accelerate bone formation due to increased osteoblastic proliferation and differentiation and its antioxidant function when pro-oxidant substances are added. These studies corroborate with the results obtained from the survey on the therapeutic uses of cowpea seeds.…”

Bone health in avoidant/restrictive food intake disorder: a narrative review

“…The skeletal matrix comprises an integrated framework of type 1 collagen, which serves as scaffolding for the mineral hydroxyapatite component of bone. Vitamin C is involved in collagen synthesis and modification of bone turnover through the wnt/β-catenin signaling pathway [ 31 , 32 ]. Although vitamin C deficiency is uncommon in the general population, several recent clinical case reports discuss the development of scurvy in patients with ARFID and its subsequent effects on bone health [ 30 , 33 ].…”

Multifactorial Effect of Ascorbic Acid on the Process of Reparative Osteogenesis

“…Однократное внутримышечное введение 0,5 мг/кг аскорбиновой кислоты при расширении верхней челюсти крыс через 24 ч после травмы стимулирует ее оссификацию [39] и ускоряет заживление экспериментального перелома большеберцовой кости крыс [5].…”

“…Однако аналогичное введение равных объемов официнальных 5%-ных растворов АК и глюкозы либо 5%-ного раствора АК в том же периоде индуцирует формирование фиброзного сращения сопоставленных отломков вертлужной впадины [41,42]. Очаговое введение раствора аскорбиновой кислоты (0,5 мг/кг) непосредственно в область нарушенного соединения верхнечелюстных костей крыс через 24 ч после травмы также предотвращает ее оссификацию [5].…”