Clinical effect of intravenous immunoglobulin on chronic idiopathic thrombocytopenic purpura

Abe, Takeshi; Matsuda, Juzo; Kawasugi, Kazuo; Yoshimura, Yuichi; Kinoshita, Tadatoshi; Kazama, Mutsuyoshi

doi:10.1007/bf02482640

Cited by 28 publications

(1 citation statement)

References 19 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response to high-dose gamma globulin in our patient was rapid, as in previous reports of patients with ITP given this treatment (8)(9)(10)(11)(12)(13)(14)(15)(16)(17). This response was associated with a blockade of the RES Fc receptors, as evidenced by a prolongation of clearance of anti-Rh(D)-sensitized radiolabeled autologous erythrocytes.…”

supporting

confidence: 82%

Treatment of gold‐induced thrombocytopenia by high‐dose intravenous gamma globulin

Goldstein

Blanchette

Huebsch

et al. 1986

Arthritis & Rheumatism

View full text Add to dashboard Cite

supporting

confidence: 82%

Treatment of gold‐induced thrombocytopenia by high‐dose intravenous gamma globulin

Goldstein

Blanchette

Huebsch

et al. 1986

Arthritis & Rheumatism

View full text Add to dashboard Cite

Use of intravenous immunoglobulin in various medical conditions. A Japanese experience

Abe¹,

Kawasugi²

1991

Cancer

View full text Add to dashboard Cite

The main clinical indications for intravenous immunoglobulin (IVIG) therapy in Japan are severe bacterial and viral infections as a result of primary and secondary immunodeficiencies, idiopathic thrombocytopenic purpura (ITP), autoimmune diseases, hematologic disorders, acquired immune deficiency syndrome, and Kawasaki disease. Experiences using IVIG to treat patients with severe infectious diseases, Kawasaki disease, and ITP are reported in this article. In patients with severe infections, IVIG showed some clinical benefits. In patients with Kawasaki disease, combined administration of IVIG and aspirin reduced the incidence of coronary artery lesions below that of aspirin alone or without therapy, and persistence of these lesions also decreased in patients who received combination therapy. Organ platelet sequestration, measured with indium 111‐labeled platelets, showed a splenic pattern in good responders to IVIG, a hepatic pattern in fair responders, and a splenohepatic pattern in poor responders. These patterns might provide some insight into the use of IVIG. Some reaction mechanisms also are discussed.

show abstract

Naturally Occurring Antibodies/Autoantibodies in Polyclonal Immunoglobulin Concentrates

Späth

Lutz

2012

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

It was a long way from the use of hyperimmune animal sera for the treatment of toxin-producing infections to the production of polyclonal, polyspecific human immunoglobulin preparations and the use of NAbs as therapeutic tools for autoimmune and inflammatory diseases. Some highlights of the development of knowledge in blood fractionation techniques, basic science and clinical wisdom are reviewed in this chapter. Proudly we mention the outstanding contribution of Swiss scientists and clinicians in the development of IVIG as clinical tool for some otherwise untreatable diseases or taking advantage of its low adverse event profile in long-term treatment of other chronic autoimmune and inflammatory diseases. This chapter summarizes some of the characteristics and the effects in humans of NAbs which are present in IgG concentrates. We call attention to the fact that the human data remain, at least in part, incomplete, among others because even with the most efficient large-scale techniques available not more than approximately 50% of the total IgG in plasma can be fractionated into an immunoglobulin G concentrate.

show abstract

Clinical effect of intravenous immunoglobulin on chronic idiopathic thrombocytopenic purpura

Cited by 28 publications

References 19 publications

Treatment of gold‐induced thrombocytopenia by high‐dose intravenous gamma globulin

Treatment of gold‐induced thrombocytopenia by high‐dose intravenous gamma globulin

Use of intravenous immunoglobulin in various medical conditions. A Japanese experience

Naturally Occurring Antibodies/Autoantibodies in Polyclonal Immunoglobulin Concentrates

Contact Info

Product

Resources

About