Clinical effect of a constant rate infusion of alfaxalone in isoflurane-anesthetized goats undergoing an experimental procedure: a pilot study

Rodrigo-Mocholí, Diego; Gasthuys, Frank; Vlaminck, Lieven; Schauvliege, Stijn

doi:10.21825/vdt.v89i1.15980

Cited by 2 publications

(2 citation statements)

References 18 publications

(26 reference statements)

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“…Furthermore, it does not seem to have less cumulative effects after repeated doses, thereby exhibiting rapid recovery in dogs [ 4 ]. Alfaxalone has been also used as both an induction and maintenance agent in other species such as goats [ 5 , 6 ] sheep [ 7 , 8 ], horses [ 9 , 10 ] and donkeys [ 11 ]. Alfaxalone anesthesia showed minimal effects on cardiorespiratory variables with prolonged recovery times in sheep and goats [ 5 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats

Abouelfetouh

Liu

Salah

et al. 2021

Animals

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Goats have been used as animal models in research and are increasingly kept as companion animals. However, information about effective anesthetic drugs is scarce in this species. The objective of this study was to evaluate the effect of xylazine premedication on alfaxalone induction. Twelve clinically healthy goats weighing 18.5 ± 2 kg were randomly assigned to two groups. Induction was performed with alfaxalone alone intravenously (ALF group) or with xylazine premedication before alfaxalone administration (XYL-ALF group). The quality of induction was scored, induction doses of alfaxalone were determined, and cardiorespiratory parameters and nociceptive thresholds were measured before any treatment(s) (baseline) and at 5, 15, 25 and 35 min after alfaxalone administration. The mean dose of alfaxalone required for induction in the ALF group was greater than that in the XYL-ALF group (p < 0.001). There were no significant changes in diastolic arterial pressure (DAP), mean arterial pressure (MAP) or systolic arterial pressure (SAP) compared to baseline in either group, while hemoglobin oxygen saturation (SpO2) was lower from 5 to 25 min (p < 0.5) in the XYL-ALF group. The nociceptive threshold was significantly higher at 5 min in the XYL-ALF group than in the ALF group (p = 0.0417). Xylazine premedication reduced the required dose of alfaxalone for anesthetic induction and produced better antinociception than alfaxalone alone. In addition, the combination of xylazine and alfaxalone allowed for successful induction; however, oxygen supplementation is necessary to counteract xylazine-associated hypoxemia.

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Section: Introductionmentioning

confidence: 99%

The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats

Abouelfetouh

Liu

Salah

et al. 2021

Animals

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“…Compared to other anesthetic agents, alfaxalone has several merits, including a broad margin of safety and fast onset of action, and less cumulative effects following repeated dosages [7]. Recently, alfaxalone has been reported to have minimal hemodynamic effects during anesthesia in goats [8][9][10] and sheep [11].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Minimum Infusion Rate of Alfaxalone Combined with Electroacupuncture in Goats

Liu

Abouelfetouh

Salah

et al. 2021

Animals

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Total intravenous anesthesia (TIVA) is increasingly used in companion animals. The effect of electroacupuncture (EA) on alfaxalone-based TIVA has not been previously reported in goats. Therefore, the objective of this study was to determine the minimum infusion rate (MIR) of alfaxalone required to prevent purposeful movement of the extremities in response to standardized noxious stimulation during its combination with EA in goats. Twelve clinically healthy goats weighing 18.5 ± 2 kg were randomly assigned to two groups (six goats/group). Alfaxalone alone (ALF group) and alfaxalone combined with EA (EA-ALF group). In the EA-ALF, alfaxalone was administered 30 min after EA stimulation. For induction of anesthesia, a bolus of alfaxalone was given at 3 mg/kg IV, and an infusion dose of 9.6 mg/kg/h was initially set for maintenance. The MIR of alfaxalone in both groups was determined by testing for responses to stimulation (clamping on a digit with Vulsellum forceps) at 10-min intervals after induction of anesthesia till the entire period of the experiment. Cardiopulmonary parameters and nociceptive threshold were measured throughout anesthesia. The median alfaxalone MIR was significantly lower in the EA-ALF group than the ALF group [9 (4.8–9.6) and 12 (11.4–18)], respectively; p = 0.0035). In the ALF group, goats anesthetized with MIR showed a significant increase in heart rate and cardiac output (p < 0.0001 and 0.0312, respectively), and decrease in respiratory rate (p < 0.0001), hemoglobin oxygen saturation (p = 0.0081), and rectal temperature (p = 0.0046) compared with those in the EA-ALF. Additionally, goats in the EA-ALF showed a higher nociceptive threshold than those in the ALF group (p < 0.0001). EA provided analgesia, reduced the MIR of alfaxalone-based IV anesthesia and thereby alleviated the adverse cardiorespiratory effects associated with alfaxalone anesthesia in goats.

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Clinical effect of a constant rate infusion of alfaxalone in isoflurane-anesthetized goats undergoing an experimental procedure: a pilot study

Abstract: Clinical effect of a constant rate infusion of alfaxalone in isoflurane-anesthetized goats undergoing an experimental procedure: a pilot studyKlinisch effect van een infusie van alfaxalone bij geiten tijdens experimenteel onderzoek onder anesthesie met isofluraan: een pilootstudie 1

Cited by 2 publications

References 18 publications

The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats

The Effect of Xylazine Premedication on the Dose and Quality of Anesthesia Induction with Alfaxalone in Goats

Determination of the Minimum Infusion Rate of Alfaxalone Combined with Electroacupuncture in Goats

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