Clinical Disease, Drug Susceptibility, and Biochemical Patterns of the Unnamed Third Biovariant Complex of Mycobacterium fortuitum

Wallace, Richard J.; Brown, Barbara A.; Silcox, Vella A.; Tsukamura, M; Nash, Donald R.; Steele, Lorraine C.; Steingrube, Vincent A.; Smith, Jennifer L.; Sumter, G; Zhang, Yansheng; Blacklock, Zeta M.

doi:10.1093/infdis/163.3.598

Cited by 73 publications

(117 citation statements)

References 18 publications

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“…peregrinum type III is a rapidly growing mycobacteria belonging to the M. fortuitum group (3) which also includes M. fortuitum, M. fortuitum third variant (19), M. mucogenicum, and M. senegalense. Although M. peregrinum was first proposed in 1962, only in the last years has been systematicly included (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Torres‐Duque¹,

Diaz²,

Vargas³

et al. 2011

biomedica

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Rapidly growing mycobacteria are non-tuberculous mycobacteria amply present in the environment. Although they are not usually pathogenic for humans, they are opportunistic in that they can cause disease in people with disadvantageous conditions or who are immunocompromised. Mycobacterium peregrinum, an opportunistic, rapidly growing mycobacteria, belongs to the M. fortuitum group and has been reported as responsible for human cases of mycobacteriosis. A case of M. peregrinum type III is herein reported as the first in Colombia. It presented as a disseminated disease involving a prosthetic aortic valve (endocarditis) in a seventeen-year-old girl with a well-established diagnosis of prosthetic aortic valve endocarditis who was referred for a surgical replacement. Due to a congenital heart disease (subaortic stenosis with valve insufficiency), she had two previous aortic valve implantation surgeries. One year after the second implantation, the patient presented with respiratory symptoms and weight lost indicative of lung tuberculosis. A chest X-ray did not show parenchymal compromise but several Ziehl-Neelsen stains were positive. An echocardiography showed a vegetation on the prosthetic aortic valve. In blood and sputum samples, M. peregrinum type III was identified through culture, biochemical tests and hsp65 gene molecular analysis (PRA). The patient underwent a valve replacement and received a multidrug antimycobacterial treatment. Progressive recovery ensued and further samples from respiratory tract and blood were negative for mycobacteria.Key words: Mycobacterium, Mycobacterium peregrinum infections, aortic valve, endocarditis, Colombia. Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en ColombiaLas micobacterias de rápido crecimiento son microorganismos pertenecientes a las micobacterias no tuberculosas que tienen amplia distribución ambiental. Aunque usualmente no son patógenas para los humanos, en condiciones desfavorables, pueden causar enfermedad en la población general o en huéspedes inmunocomprometidos, por lo cual se consideran oportunistas. Mycobacterium preregrinum es una micobacteria de rápido crecimiento perteneciente al complejo fortuitum que ha sido reportado como responsable de casos de micobacteriosis en humanos. Se presenta el caso de una micobacteriosis por M. peregrinum de tipo III, el primero reportado en Colombia, en una paciente de 17 años de edad con una endocarditis de una válvula aórtica protésica, implantada inicialmente por estenosis subaórtica congénita con insuficiencia y, posteriormente, por estenosis aórtica relacionada con la válvula inicialmente implantada. Un año después del segundo implante, presentó sintomas respiratorios y pérdida de peso sugestivos de tuberculosis pulmonar. Las coloraciones de Ziehl-Neelsen del esputo fueron positivas aunque la radiografía de tórax no mostró compromiso del parénquima. En el ecocardiograma se encontró una vegetación en la válvula aórtica. En las muestras...

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Section: Discussionmentioning

confidence: 99%

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Torres‐Duque¹,

Diaz²,

Vargas³

et al. 2011

biomedica

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“…fortuitum-group members cause a variety of human infections . Accurate bacterial identification, rising from a relevant classification, is crucial as antimicrobial resistance is species-dependent (Wallace et al, 1991).…”

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confidence: 99%

Mycobacterium setense sp. nov., a Mycobacterium fortuitum-group organism isolated from a patient with soft tissue infection and osteitis

Lamy¹,

Marchandin

Hamitouche³

et al. 2008

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLO

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“…various carbohydrates and immunodiffusion patterns of strains that belong to the M. fortuitum complex revealed more than one hundred strains that differed from the above species (Silcox et al, 1981; LCvy-FrCbault et al, 1983; Labidi et al, 1984; Wallace et al, 1991). In one study (Wallace et al, 1991), the isolates that did not correspond to recognized species represented 16-22% of the examined strains and were mostly involved in skin, soft-tissue or bone infections.…”

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confidence: 99%

“…In one study (Wallace et al, 1991), the isolates that did not correspond to recognized species represented 16-22% of the examined strains and were mostly involved in skin, soft-tissue or bone infections. Furthermore, studies of the 16s rRNA (Kirschner et al, 1992; Springer et al, 1995) showed that some of these strains probably belong to an unidentified species.…”

mentioning

confidence: 99%

“…Furthermore, studies of the 16s rRNA (Kirschner et al, 1992; Springer et al, 1995) showed that some of these strains probably belong to an unidentified species. Although the strains were heterogeneous in terms of their ability to use sorbitol as carbon source, the intensity of their catalase reaction, the electrophoretic pattern of their 8-lactamase, and their resistance to cefoxitin, this group of strains was named the third biovariant complex of M. fortuitum (Wallace et al, 1991) because of their close taxonomic relatedness with M. fortuitum (formerly M. fortuitum subsp. Jortuitum) and M. peregrinum (formerly M. fortuitum subsp.…”

mentioning

confidence: 99%

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Structures of the Glycolipid Antigens of Members of the third Biovariant Complex of Mycobacterium Fortuitum

Lanéelle

Silve

López-Marı́n

et al. 1996

European Journal of Biochemistry

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Among the fast-growing mycobacteria, members of the Mycobacterium fortuitum complex are the most-commonly cited opportunistic human pathogens, notably in post-surgical infections. Previous studies showed that this complex was composed of four well-identified species and a group of isolates that did not correspond to recognized species, which has been referred to as the third biovariant complex. The occurrence and chemical structure of the glycolipid antigens of six strains that belong to this latter group were examined in the present study. Based on the TLC profiles, resistance to alkali and seroreactivities of their glycolipids, the examined strains were classified into three groups: one group was devoid of species-specific glycolipid and the two other groups contained alkali-stable or alkali-labile glycoconjugates. The structures of the major glycolipid antigens of the latter two groups were elucidated by fastatom-bombardment MS, one-dimensional and two-dimensional NMR spectroscopy and conventional chemical analyses. The alkali-stable glycolipids were structurally identical to the C-mycoside-type glycopeptidolipids characterized in the taxonomically related species Mycobacterium peregrinum. The major alkali-labile glycolipid was identified as ~-Glcp-(1-+6)-a-Glcp2Acyl-(l-l)-a-Glcp3,4,6Acyl,. The acyl substituents consisted of one acetyl group and three fatty acyl residues composed mainly of tetradecanoyl residues, but significant amounts of 2-methylhexadecanoyl and 2-methyloctadecanoyl substituents were also present. The heterogeneity of the glycolipid content of members of the third biovariant complex of M. fortuitum demonstrated in the present study confirms the heterogeneity of the complex. In addition, the occurrence of a species-specific glycolipid in some strains supports the hypothesis that some strains of this complex of M. fortuitum may belong to a new mycobacterial species.Keywords: antigen ; glycopeptidolipid ; lipooligosaccharide ; mycobacteria.Interest in mycobacteria other than Mycobacterium tuberculosis has been renewed by the increased frequency of clinical infections caused by these organisms (Woods and Washington, 1987). Unlike M. tuberculosis, whose host is man, most other mycobacteria are environmental microorganisms widely distributed in nature. Among the fast-growing mycobacteria, the mostcommonly cited opportunistic human pathogens, notably in post-surgical infections, are members of the Mycobacterium fortuitum complex (Good, 198.5). Biovariants and subspecies of this complex have frequently been misidentified and can, with difficulty, be recognized as distinct species. Strains that belong to this complex are resistant to most antimycobacterial drugs, and their response to other antimicrobial agents depends on the species and biovariant or subspecies (Good, 1985). The the third biovariant (LCvy-Frtbault et al., 1983). The glycolipid content of M. fortuitum differs from that of M. peregrinum

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Clinical Disease, Drug Susceptibility, and Biochemical Patterns of the Unnamed Third Biovariant Complex of Mycobacterium fortuitum

Cited by 73 publications

References 18 publications

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Mycobacterium setense sp. nov., a Mycobacterium fortuitum-group organism isolated from a patient with soft tissue infection and osteitis

Structures of the Glycolipid Antigens of Members of the third Biovariant Complex of Mycobacterium Fortuitum

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