Clinical diagnostic problems associated with cecal ameboma. Case report and review of the literature

Radovanović, Zoran; Katić, Vuka; Nagorni, Aleksandar; Živković, Vesna; Stanković, Tatjana; Trenkic-Božinović, Marija

doi:10.1016/j.prp.2007.07.002

Cited by 9 publications

(5 citation statements)

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“…The high sensitivity of a finding of multiple lesions for a diagnosis of amebic colitis may be attributed to the infrequent presence of solitary amebic colitis lesions. In fact, solitary lesions, referred to as "amebomas," are not common in patients with amebic colitis [12,15,16]. An ameboma is a mass of necrotic tissue that forms as a result of localized inflammation and resembles a tumor [12,15,16] and was only found in two patients in the present study.…”

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confidence: 67%

“…In fact, solitary lesions, referred to as "amebomas," are not common in patients with amebic colitis [12,15,16]. An ameboma is a mass of necrotic tissue that forms as a result of localized inflammation and resembles a tumor [12,15,16] and was only found in two patients in the present study. Among the macroscopic findings, the presence of ulcer was not associated with high diagnostic accuracy.…”

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confidence: 67%

“…Based on data from the present study, the "aphthae or erosions" finding was associated with better diagnostic value than the "ulcer" finding. This may be because ulcers seen in amebic colitis, which are sometimes described as flask-shaped, small, punctuate, or discrete [4,5,11,16], are also frequently observed in patients with infectious colitis and IBD. Previous studies also suggest that a finding of exudate often accompanies a finding of ulcer or erosion [6].…”

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confidence: 99%

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Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis

et al. 2012

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Endoscopic diagnosis of amebic colitis can be difficult because its appearance may mimic other forms of colonic disease. The aim of this study was to identify predictive endoscopic findings for amebic colitis. Patients with suspected amebic colitis based on distinctive endoscopic findings such as aphthae or erosions, ulcers, exudates, or a bump, were included in the study. A total of 157 patients were selected, 50 of whom had amebic colitis. The sensitivity and specificity of endoscopic findings that were significantly associated with amebic colitis were: cecal lesions (80% and 54%), multiple number of lesions (96% and 29%), presence of aphthae or erosions (84% and 37%), and presence of exudate (88% and 74%). Multivariate analysis revealed that the best combination of findings to predict amebic colitis was the presence of cecal lesions, multiple lesions, and exudates, which corresponded to an area under the receiver operating characteristic curve of 0.89 (95% confidence interval 0.82-0.95).

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confidence: 67%

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confidence: 67%

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Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis

et al. 2012

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“…Amoebiasis causes up to 100.000 deaths annually all over the world, E. histolytica known as the main agent of intestinal amoebiasis causing amebic colitis and liver abscess, is morphologically identical with E. dispar, which is accepted as a non-pathogenic commensal parasite (5) . Amoebiasis is an infection caused by Entamoeba histolytica with or without symptoms.…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection of Shigella spp. and Entamoeba Histolytica Causing Bacillary and Amoebic Dysentery among Children in Ramadi City

2017

Al-Anbar Medical Journal

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Background and objective:-Dysentery as any episode of diarrhea in which there is blood in loose and watery stool, there are different types of pathogens that can cause acute dysentery, including Shigella spp. and Entamoeba histolytica. The aims of this study was to isolate Shigella spp. and Entamoeba histolytica causing both bacillary and amoebic dysentery respectively, in children less than five years of age by conventional techniques. Also, molecular detection of Shigella spp. and Entamoeba histolytica was achieved. Patients and methods:-One hundred and forty five stool specimens obtained from children were admitted Maternity and Child Teaching Hospital in Ramadi with acute diarrhea with the mean age (2.168±12.571) were enrolled in the study from January 2014 to March 2015. PCR was used to amplify specific oligonucleotide sequences with 320 base pair coding for (ial) gene for Shigella spp. and Entamoeba histolytica (16S-rRNA) gene with 439 base pair. Results:-The stool specimens had been taken from 145 patients divided into 75(51.7%) patients yielded amoebic dysentery and others 70(48.3%) from these with bacillary dysentery. In the molecular part of this study molecular part of study, our results showed that 30 out of 75(40%) extracted DNA for E. histolytica were produced strong bands revealed positivity of PCR technique while the other 45(60%) were negative. The result of PCR technique among Shigella spp. revealed that 30 out of 70(42.86%) were positive and in contrast 40/70 (57.14%) samples were negative. Conclusion:-The study suggested that PCR has several advantages over the conventional methods for the diagnosis of bacillary and amoebic dysentery such as safety, high sensitivity and specificity. Our results demonstrated that the value of using a combination of traditional and molecular techniques in the diagnosis of diarrheal disease in this population. This study has been providing comparable results of microscopy and PCR, none of these methods can detect all positives alone. According to our findings, microscopy is a simple analysis, but it is subjective, needs experience to evaluate and should be combined with complimentary methods such as antigen detection and PCR for identification of the species to avoid false and/ or insufficient diagnosis and treatment applications.

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“…E. histolytica, known as the main agent of intestinal amebiasis causing amebic colitis and liver abscess, is morphologically identical with E. dispar, which is accepted as a non-pathogenic commensal parasite (1). Microscopy, stool culture, serological methods including antibody and antigen detection, and molecular tools such as polymerase chain reaction (PCR) are the methods for the diagnosis of amebiasis.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Entamoeba histolytica/Entamoeba dispar by the Polymerase Chain Reaction in Stool Samples of Patients with Gastrointestinal Symptoms in the Sanliurfa Province

Zeyrek¹,

Turgay²,

Ünver³

et al. 2013

TurkiyeParazitolDerg

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Objective: We aimed to diagnose amebiasis and also identify Entamoeba histolytica (E. histolytica) and Entamoeba dispar (E. dispar) in patients with gastrointestinal symptoms in an endemic region in Turkey. Methods: Stool samples obtained from 181 patients with gastrointestinal symptoms from the Harran University Hospital of Sanliurfa were examined for the diagnosis of amebiasis by the three methods which are as follows:-In house polymerase chain reaction (PCR) targeting the 135 base pair region located on the small-subunit ribosomal RNA (SSU rRNA) gene to differentiate E. histolytica from E. dispar; and the commercial kit, RIDASCREEN ® stool ELISA, that identifies Entamoeba sensu lato antigen and microscopical examination of Trichrome stained smears of stool samples. Results: Positivity for E. histolytica/E. dispar complex was found to be 79 (43.6%) by microscopy versus 83 (45.9%) by PCR out of 181 stool samples. A total of 45 patients were found to be positive by the antigen detection method. PCR and microscopy were both positive in 59 samples. The number of patients infected with E. dispar (39.8%) was found to be higher than E. histolytica (3.3%) while 5 patients (2.8%) had mixed E. histolytica+E. dispar infections according to PCR results. Conclusion: Routine diagnosis of amebiasis by a combination of microscopy and antigen detection technique should be complemented with a PCR assay as a reference test for sensitive differentiation of both species. (Turkiye Parazitol Derg 2013; 37: 174-8)

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Clinical diagnostic problems associated with cecal ameboma. Case report and review of the literature

Cited by 9 publications

References 9 publications

Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis

Predictive value of endoscopic findings in the diagnosis of active intestinal amebiasis

Molecular Detection of Shigella spp. and Entamoeba Histolytica Causing Bacillary and Amoebic Dysentery among Children in Ramadi City

Differentiation of Entamoeba histolytica/Entamoeba dispar by the Polymerase Chain Reaction in Stool Samples of Patients with Gastrointestinal Symptoms in the Sanliurfa Province

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