Clinical diagnosis of vascular dementia

Nagata, Ken; Saito, Hirohiko; Ueno, Tomoyuki; Nakase, Taizen; Maeda, Tetsuya; Satoh, Yuichi; Komatsu, Hiromi; Suzuki, Miyuki; Kawakami, Yasushi

doi:10.1016/j.jns.2007.01.049

Cited by 29 publications

(19 citation statements)

References 25 publications

(34 reference statements)

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“…Our solution was to group according to no vascular genesis (AD), or vascular genesis with possible supplementary (primary degenerative) pathogenesis. Thus, we included MD in the diagnosis of VaD, a practice previously suggested by others [42] . We believe that the results we present, with the clear-cut neuropsychological differences, speak in favor of the validity of such a diagnostic grouping.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study

Nordlund

Rolstad

Göthlin

et al. 2010

Dement Geriatr Cogn Disord

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Objective: To study which cognitive profiles of incipient dementia strongest predict the conversion to Alzheimer’s disease (AD) and mixed dementia (MD)/vascular dementia (VaD). Methods: 260 subjects with mild cognitive impairment (MCI) were included in the study and 209 (79%) were followed up after 2 years. At baseline, the subjects were assessed with a neuropsychological battery covering the cognitive domains speed/attention, memory, visuospatial, language and executive functions. Results: After 2 years, 9 subjects were considered normal, 148 had stationary MCI and 47 (23%) had converted to dementia. Twenty subjects were diagnosed with AD, 15 with MD and 9 with VaD. The others were 2 with unspecified dementias and 1 with primary progressive aphasia. Dementia converters had a high proportion of impairment in all cognitive domains. The profiles of incipient AD and MD/VaD differed, with memory, visuospatial and language symptoms preceding AD, and executive and speed/attention symptoms preceding MD/VaD. Conclusions: The risk of converting to dementia is increased when domains in addition to memory are impaired. The incipient AD and MD/VaD profiles differed quite clearly. Considering that the vascular group consisted of a majority of patients with MD, the differences are convincing – vascular disease seems to have an essential impact on cognition.

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Section: Discussionmentioning

confidence: 99%

Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study

Nordlund

Rolstad

Göthlin

et al. 2010

Dement Geriatr Cogn Disord

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“…However, some evidence suggests that particularly in elderly patients there is considerable overlap between AD and VaD [13,14]. This coexistence of both pathologies is named mixed dementia (MD) and vascular pathology occurs in from 25% to more than 50% of AD cases [15].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

Gackowski

Różalski

Siomek

et al. 2008

Journal of the Neurological Sciences

103

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“…Reflex asymmetry, hemi-motor dysfunction and dysarthria are the most common finding but many different neurological signs or symptoms can present. 21,22 Of the 12 cases referred for MRI or Brain SPECT, 11 ended up having neurological illnesses. It is unlikely that such a high positive yield is a reflection of the clinician's diagnostic accuracy.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic outcome of patients referred to psychiatry with medically unexplained symptoms: a retrospective study

Govender¹,

Oosthuizen²,

Cloete³

2011

Afr. J. Psych

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Objective: Medically unexplained symptoms (MUS) are commonly encountered in medical practice. In psychiatry, they are classified mostly as Somatoform Disorders and are often associated with anxiety and depression. The literature suggests that, in some cases, MUS may be ascribed to Somatoform Disorders when, fact, they are "organic" syndromes that are misdiagnosed. In developing countries, with fewer resources, MUS may be more difficult to assess. Method: We undertook a retrospective chart review to examine the demographics, referral pathway, management and diagnostic outcome of subjects (n = 50) referred to psychiatry with MUS over an 18 month period. Results: Subjects with MUS accounted for only 4.5% of the total number of files reviewed. In only 38% of cases did the final diagnosis in psychiatry concur with the referral diagnosis. In 28% of cases a new "organic" diagnosis was made and in 72% of cases a new psychiatric diagnosis was made. Subjects who were diagnosed with "organic" illness were seen fewer times prior to referral to psychiatry and were significantly older than other subjects. Conclusion: In developing countries like SA, a significant number of patients with MUS may have underlying "organic" illness, and most may have psychiatric disorders. Patients with MUS, especially older patients, should be more extensively investigated. Psychiatric referral of these patients is very appropriate.

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Clinical diagnosis of vascular dementia

Cited by 29 publications

References 25 publications

Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study

Cognitive Profiles of Incipient Dementia in the Goteborg MCI Study

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

Diagnostic outcome of patients referred to psychiatry with medically unexplained symptoms: a retrospective study

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