Clinical description of human bocavirus viremia in children with LRTI, Eastern Province, Saudi Arabia

Bubshait, Dalal; Albuali, Waleed H.; Yousef, Abdullah A; Obeid, Obeid Eltreifi; Alkharsah, Khaled R.; Hassan, Manal; Vatte, Chittibabu; Alzahrani, Alhusain J.; Bukhari, Huda

doi:10.4103/1817-1737.151437

Cited by 22 publications

(18 citation statements)

References 12 publications

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“…In some studies, high viral loads during acute infection have further been shown to correlate with increased symptom severity or duration (290,1026,1029), while other studies found no such differences (285,1028). Lower respiratory tract infection has been correlated with the detection of HBoV1 spliced mRNA, an indirect marker of active HBoV1 replication, in nasopharyngeal aspirates (997,1001,1032) and the detection of viral DNA in serum (viremia) (1009,1033). In a clinical assessment of HBoV1 infection among 258 wheezing children (332), 96% of the children with HBoV1 loads of Ͼ10 4 vgc/ml in nasopharyngeal aspirates also had a serodiagnosis (IgM and often also IgG conversion or a Ն4-fold increase in the IgG level), compared with only 38% of the children with low viral DNA loads.…”

Section: Diseases Associated With Hbov Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Diseases Associated With Hbov Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…HBoV have been detected mostly in respiratory tract secretions and stool, however the viruses have been found in serum and cerebrospinal fluid causing viremia (15,16). Likewise, several studies have reported HBoV in sewage and river water (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Detection and Molecular Epidemiology of Human Bocavirus in Children with Acute Gastroenteritis from Brazil

Soares

Lima

Pantoja

et al. 2018

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SUMMARYHuman Bocavirus (HBoV) is a recently discovered virus and was first detected in the nasopharyngeal aspirate samples and after in stool samples, suggesting that HBoV may be a causative agent for human enteric infections. Due to absence of treatment options, there is a need to understand the disease-causing mechanism of these viruses. The aim of this was to demonstrate the prevalence of HBoV from children less than 10 years with acute gastroenteritis in Brazil, during November 2011 to November 2012. Stool samples from hospitalized children ≤ 10 years who presented symptoms of acute gastroenteritis were analyzed for the presence of HBoV DNA by nested-PCR. HBoV- positivity was detected in 24.0% (54/225) of samples. Two peaks of HBoV detection were observed, during November 2011 and July to September 2012. Co-infections between HBoV and rotavirus A were identified in 50.0% (27/54) of specimens. Phylogenetic analysis identified the presence of HBoV-1 (94.8%), HBoV-2 (2.6%) and HBoV-3 (2.6%) species, with only minor variations among them. Further investigations are necessary to improve the knowledge on the role of HBoV in gastrointestinal infections.

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“…Dear editor, the recent report on 5 cases with bocavirus viremia is very interesting. [ 1 ] Bubshait et al . noted that “wheezing was a striking feature in most of our patients, but fever was not a consistent finding.”[ 1 ] In fact, bocavirus infection is a new infection that can be seen around the world.…”

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confidence: 99%