Clinical, dermoscopic and histopathological findings in localized human monkeypox: a case from northern Italy

Maronese, Carlo Alberto; Beretta, Andrea; Avallone, Gianluca; Boggio, Francesca; Marletta, Dario A; Murgia, Giulia; Cusini, Marco; Gori, Andrea; Carrera, Carlo Giovanni; Benedetto, Alessandra Di; Ramoni, Stefano; Marzano, Angelo Valerio

doi:10.1111/bjd.21773

Cited by 38 publications

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“…After the removal of duplicates (n = 738), 553 articles were screened by the reviewers. After filtering the titles and reading the abstracts, 74 articles were selected for full-text reading, and 28 were considered eligible for inclusion in this systematic review [ 7 , 8 , 22 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ] ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The main characteristics of the articles included in this review are summarized in Table 2 . Our review included 28 studies that were published between 1 January and 18 August 2022 [ 7 , 8 , 22 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. The studies (n = 28) reported case reports of sexually transmitted monkeypox with a detailed description of the number of cases, clinical manifestations, history of sexually transmitted diseases, method of diagnosis, location and course of skin lesions, and treatment ( Table 2 and Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…The studies (n = 28) reported case reports of sexually transmitted monkeypox with a detailed description of the number of cases, clinical manifestations, history of sexually transmitted diseases, method of diagnosis, location and course of skin lesions, and treatment ( Table 2 and Table 3 ). A total of 4222 confirmed cases of monkeypox were reported [ 7 , 8 , 22 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ], of which 3876 cases of monkeypox were the result of sexual contact transmission, distributed in twelve countries: Germany (n = 357) [ 38 , 43 , 48 ], Korea (n = 1) [ 39 ], Spain (n = 1924) [ 41 , 42 , 44 , 46 , 51 ], Italy (n = 42) [ 7 , 8 , 50 ], United Kingdom (n = 364) [ 31 , 33 , 37 , 47 …”

Section: Resultsmentioning

confidence: 99%

“…Of the total number of cases (n = 4222) registered with monkeypox [ 7 , 8 , 22 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ], 4152 cases were found to be male [ 7 , 8 , 22 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ...…”

Section: Resultsmentioning

confidence: 99%

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Epidemiological Situation of Monkeypox Transmission by Possible Sexual Contact: A Systematic Review

et al. 2022

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Monkeypox (MPX), a zoonotic infection caused by the monkeypox virus (MPXV), has re-emerged worldwide with numerous confirmed cases with person-to-person transmission through close contacts, including in sexual networks. Therefore, this study aimed to determine the epidemiological situation of monkeypox transmission by possible sexual contact. A systematic literature review was conducted using PubMed, Scopus, Web of Science, and Embase databases until 18 August 2022. The key search terms used were “monkeypox”, “sexual contact”, “sexual intercourse” and “sexual transmission”. A total of 1291 articles were retrieved using the search strategy. After eliminating duplicates (n = 738) and examining by title, abstract, and full text, 28 studies reporting case reports of monkeypox with a detailed description of clinical features, sexually transmitted diseases, method of diagnosis, location and course of skin lesions, and treatment were included. A total of 4222 confirmed cases of monkeypox have been reported, of which 3876 monkeypox cases are the result of transmission by sexual contact distributed in twelve countries: 4152 cases were male with a mean age of 36 years. All confirmed cases of monkeypox were diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR). The most frequent clinical manifestations were fever, lymphadenopathy, headache, malaise, and painful perianal and genital lesions. The most frequent locations of the lesions were perianal, genital, oral, trunk, upper and lower extremities. Patients were in good clinical condition, with treatment based on analgesics and antipyretics to relieve some symptoms of monkeypox. A high proportion of STIs and frequent anogenital symptoms were found, suggesting transmissibility through local inoculation during close skin-to-skin or mucosal contact during sexual activity. The highest risk of monkeypox transmission occurs in men who have sex with men, and MPXV DNA could be recovered in seminal fluid. It is essential to establish health policies for the early detection and management of patients with monkeypox.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological Situation of Monkeypox Transmission by Possible Sexual Contact: A Systematic Review

et al. 2022

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“…Since then, monkeypox disease in humans has been reported in more than 86 developed countries, with Europe being one of the most frequently affected areas [ 6 ]. Most cases of this outbreak, technically a pandemic, have been reported in men who have sex with other men (gay and bisexual population) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Spain is one of the countries with the highest number of reported cases in the world, and the Canary Islands, in particular, are one of the regions with the highest proportion of cases per number of inhabitants [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Monkeypox and HIV in the Canary Islands: A Different Pattern in a Mobile Population

et al. 2022

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Background. The clinical and epidemiological data of the recent outbreak of monkeypox (MPX) differ from previous reports. One difference is the epidemiological profile; the disease mainly affects a subgroup of MSM (men who have sex with men) with high-risk sexual behaviors, frequently persons living with human immunodeficiency virus (PLHIV). Methods. In this observational analysis, all patients with PCR (polymerase chain reaction)-confirmed MPX attending an Infectious Diseases and Tropical Medicine Unit in Gran Canaria (Spain) between May and July 2022 were considered. Results. In total, 42 men were included; 88% were identified as MSM, with a median age of 40 years. Only 43% were born in Spain. All the patients had systemic symptoms and skin lesions. The distribution of lesions was more frequent in the genital/anal region, and the involvement of hands and feet was less common. Fever and lymphadenopathies were less frequent than in other series. Other unusual manifestations were proctitis, pharyngitis and penile–scrotal edema. Half of the patients had other associated infections (mainly STIs, sexually transmitted infections), and 60% of the monkeypox patients had PLHIV (People Living with HIV). When comparing the clinical characteristics between HIV-positive and -negative patients, we found three main differences: (i) a higher frequency of perioral lesions, (ii) a higher frequency of pharyngitis and (iii) a higher number of sexually transmitted infections in HIV-positive patients. Conclusions. The clinical findings in this outbreak of MPX had great variability in presentation. Several clinical differences were found in PLHIV-coinfected patients.

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Viral Infections

Harwood,

Sterling

2024

Rook's Textbook of Dermatology

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Viruses can cause disease in the skin or mucosa by direct infection or, via a systemic infection, produce secondary skin abnormalities. The chapter reviews the viruses associated with skin lesions, outlining the pathophysiology, the clinical features, diagnostic methods and the approaches to treatment. Primary skin infection following direct contact occurs with poxviruses, some herpesviruses and papillomaviruses leading to visible features which may be readily diagnostic. Less specific skin changes are seen with systemic infections, when infection is often via mucosae or inoculation, for example with parvovirus, measles or coronavirus and for these infections, diagnosis will usually involve body fluid analysis.

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Clinical, dermoscopic and histopathological findings in localized human monkeypox: a case from northern Italy

Abstract: Abstract

Cited by 38 publications

References 9 publications

Epidemiological Situation of Monkeypox Transmission by Possible Sexual Contact: A Systematic Review

Epidemiological Situation of Monkeypox Transmission by Possible Sexual Contact: A Systematic Review

Monkeypox and HIV in the Canary Islands: A Different Pattern in a Mobile Population

Viral Infections

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