Clinical Decision Making Using Ovarian Cancer Risk Assessment

Stany, Michael P.; Maxwell, G. Larry; Rose, G. Scott

doi:10.2214/ajr.09.3669

Cited by 13 publications

(5 citation statements)

References 43 publications

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“…Additionally PET/CT may be indicated for indeterminate lesions. Laboratory cancer antigen 125 (CA125) may also be helpful more so in post-menopausal patients ( Stany et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Jeong

Hakam

Abuel-Haija

et al. 2018

Gynecologic Oncology Reports

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Ovarian microcystic stromal tumor (MST) is characterized by microcysts, solid cellular regions with lobulated growth, and collagenous or fibrous stroma forming hyaline plaques. While several reports have evaluated the unique pathologic and immunohistochemical profile of these tumors, there has been limited description of the radiologic findings of ovarian microcystic stromal tumor in the literature. We present a case of a 66 year old female who presented for evaluation of a new cystic pelvic mass found to have ovarian microcystic stromal tumor. To our knowledge, this is one of the first reports to evaluate the radiologic features associated with this tumor. An enhanced understanding of the correlation between imaging appearance and specific histopathologic findings may aid in the early recognition of this rare neoplasm.

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“…Additionally PET/CT may be indicated for indeterminate lesions. Laboratory cancer antigen 125 (CA125) may also be helpful more so in post-menopausal patients ( Stany et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Jeong

Hakam

Abuel-Haija

et al. 2018

Gynecologic Oncology Reports

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“…Evidence from larger screening studies found a higher rate of resolution of unilocular cysts at 70%, with only complex cysts having an increased risk of malignancy 2 . Adnexal cysts 5 cm or smaller in postmenopausal women are rarely malignant [5][6][7][8] .…”

Section: Discussionmentioning

confidence: 99%

“…The exact prevalence is unknown given the limited amount of published data and the lack of established screening programs for ovarian cancer. However, studies have estimated the incidence to be anywhere between 5% and 17% 1-4 and 60-70% of unilocular cyst resolved spontaneously [5][6][7][8] . In Bangladesh we do not have exact data for the incidence but postmenopausal women with cysts are diagnosed as routine USG or in a woman who complains of slight discomfort in lower abdomen for any reason.…”

mentioning

confidence: 99%

Management of Postmenopausal Women with Simple Cyst

Nasreen¹

2017

Bangladesh J Obstet Gynaecol

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Introduction:Ovarian cysts in postmenopausal women are now known to be very common and maximum are not malignant. The exact prevalence is unknown given the limited amount of published data and the lack of established screening programs for ovarian cancer. However, studies have estimated the incidence to be anywhere between 5% and 17% 1-4 and 60-70% of unilocular cyst resolved spontaneously [5][6][7][8] . In Bangladesh we do not have exact data for the incidence but postmenopausal women with cysts are diagnosed as routine USG or in a woman who complains of slight discomfort in lower abdomen for any reason. Ovarian cancer remains the leading cause of death due to gynecological malignancy in many countries. Owing to very high mortality and severe morbidities, any postmenopausal woman is scared even with simple cyst. Before the era of USG if pelvic examination revealed palpable ovaries, those ovaries were removed. Now USG is able to detect cysts far before it becomes palpable and most of them are benign. Many women honor the ovaries and not happy to remove it. On the other hand once cysts are found in post menopausal women many women get frightened and request for the removal of cysts. So the gynecologist often faces the real challenge to treat Original Articles

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“…On the other hand, the patients with the suspicion of malignancies should be treated radically after careful treatment planning. Such radical actions influence the basic prognostic factor determining 5-year survival ( 16 ) . A proper surgical plan, among others laparotomy and midline vertical incision, which facilitates complete staging, may decrease the iatrogenic risk of increasing FIGO stage by, for instance, intraoperative rupture of the adnexal tumor ( 17 ) .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of ultrasound indicators of neoplastic risk in preoperative differentiation of adnexal masses

et al. 2013

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AimTo assess the diagnostic value of the risk of malignancy indices and simple ultrasound- based rules in preoperative differentiation of adnexal masses.Material and methodsRetrospective examination of 87 patients admitted to hospital due to adnexal tumors. The lesions were evaluated on the basis of international ultrasound classification of ovarian tumors and four risk of malignancy indices were calculated based on ultrasound examination, concentration of CA 125 and menopausal status.ResultsThe patients were aged between 17 and 79, the mean age was 44.5 (standard deviation SD=16.6). Most of the patients (60.91%) were before their menopause. The sensitivity of the simple ultrasound-based rules in the diagnosis of malignancies equaled 64.71% and the specificity constituted 90.00%. A significant statistical difference in the presence of the malignant process was demonstrated in relation to age, menopausal status, CA 125 concentration and analyzed ultrasound score. All indices were characterized by similar sensitivity and specificity. The highest specificity and predictive value of malignant lesions out of the assessed ones was demonstrated by the risk of malignancy index proposed by Yamamoto. The risk of malignancy index according to Jacobs, however, showed the highest predictive value in the case of non-malignant lesions.ConclusionsThe multiparametric ultrasound examination may facilitate the selection of patients with adnexal tumors to provide them with an appropriate treatment – observation, laparotomy and laparoscopy. These parameters constitute a simple ambulatory method of determining the character of adnexal masses before recommending appropriate treatment.

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Clinical Decision Making Using Ovarian Cancer Risk Assessment

Abstract: A patient's medical history, physical examination, CA-125 level, and imaging characteristics are all factors that impact the ultimate decision of whether a patient can be observed with repeat imaging or should proceed to surgical evaluation.

Cited by 13 publications

References 43 publications

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Ovarian microcystic stromal tumor: Radiologic-pathologic correlation

Management of Postmenopausal Women with Simple Cyst

Diagnostic value of ultrasound indicators of neoplastic risk in preoperative differentiation of adnexal masses

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