Clinical curative effect of Shanwei series decoction in treating gastric precancerous lesions

Zhang, Yuelin; Miao, Jia-Meng; Zhang, Ze; Yuan, Huipin

doi:10.11569/wcjd.v29.i8.413

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…[19][20][21] In the case of rosacea in particular, LXWHT can significantly improve the symptoms of both paroxysmal and persistent erythema with a low incidence of adverse effects. [4,5] Modern pharmacological studies indicate that Celosia cristata Flower extract can induce macrophages to produce nitric oxide synthase, cyclooxygenase-2, and cytokines, thereby modulating immune responses. [22] The aqueous extract of Chrysanthemum indicum L. can achieve anti-inflammatory effects by regulating gut microbiota and short-chain fatty acids.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies indicate that the application of LXWHT alone or in combination with other agents can significantly reduce the clinical symptoms of rosacea, including facial itching, burning, flushing, and papules, without inducing significant adverse effects. [4,5] However, the precise mechanisms of action and pharmacological effects of LXWHT remain largely unknown. Hence, there is an urgent need to identify the active components and explore the potential molecular targets of LXWHT in the treatment of rosacea.…”

Section: Herbs In Lxwht Canmentioning

confidence: 99%

“…According to the traditional theory of Chinese medicine, the formation of rosacea is mainly due to dampness, heat, and blood stasis. The 5…”

Section: Introductionmentioning

confidence: 99%

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Exploring the mechanism of Liang Xue Wu Hua Tang in the treatment of rosacea via network pharmacology and molecular docking

Cui,

Fan

2024

Medicine

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Rosacea is a chronic and recurrent inflammatory skin disease affecting the center of the face that causes burning and itching sensations and changes in aesthetics. Liang Xue Wu Hua Tang (LXWHT) is a classic herbal formulation that is efficacious and has been widely used in the clinical treatment of rosacea; however, the pharmacological mechanisms remain unclear. The aim of the present study was to investigate the mechanism of action of LXWHT using network pharmacology and molecular docking. The Traditional Chinese Medicine System Pharmacology database was searched to identify the active ingredients and pharmacological targets of LXWHT, and the GeneCard, Disgenet, and Gene Expression Omnibus databases were applied to screen rosacea-related targets. Cytoscape software was used to visualize the protein–protein interaction network, and network topology analysis was used to identify core targets. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed for the core targets. Molecular docking simulations and visualization were performed using Maestro and PyMOL, respectively. A total of 43 active compounds and 28 potential targets for LXWHT treatment of rosacea were selected for analysis. The Gene Ontology/Kyoto Encyclopedia of Genes and Genomes results indicated that LXWHT may exert therapeutic effects on rosacea by intervening in immune pathways including tumor necrosis factor pathway, interleukin-17 pathways, and Toll-like receptor signaling pathways. Chemokine ligand 2, interferon-γ, interleukin-1ß, peroxisome proliferator-activated receptor-γ, and matrix metallopeptidase 9 may be the core therapeutic target. Quercetin, stigmasterol, kaempferol, beta-sitosterol, luteolin, beta-carotene, baicalein, acetin, and isorhamnetin were predicted to be the key active ingredients. LXWHT may exert therapeutic effects in the treatment of rosacea by modulating immunity and angiogenesis, laying the foundation for further research.

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Section: Discussionmentioning

confidence: 99%

Section: Herbs In Lxwht Canmentioning

confidence: 99%