Clinical curative effect of electric acupuncture on acute cerebral infarction: a randomized controlled multicenter trial

Wang, Chengwei; Wu, Zijian; Li, Ning; Zhao, Yu; Tian, Fengwei; Zhou, Xi; Wang, Zhuxing

doi:10.1016/s0254-6272(15)30075-3

Cited by 20 publications

(13 citation statements)

References 2 publications

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“…Even though patients with stroke experience multiple symptoms simultaneously, many studies examining the impact of acupuncture on stroke often focus on a single dysfunction or on one type of standardised treatment. Acupuncture shows promise in randomised controlled trials (RCTs) assessing its impact on specific types of dysfunction, including poststroke dysphagia, 4 hiccups, 5 depression, 6 activities of daily living (ADLs) 7 and disability. 8 One recent meta-analysis concluded that acupuncture combined with rehabilitation may be more effective than rehabilitation alone, but called for greater consensus on treatment protocols and the duration of intervention.…”

Section: Introductionmentioning

confidence: 99%

Retraction: Effect of Acupuncture and Chinese Herbal Medicine on Subacute Stroke Outcomes: A Single Center Randomized Controlled Trial

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Retraction: Effect of Acupuncture and Chinese Herbal Medicine on Subacute Stroke Outcomes: A Single Center Randomized Controlled Trial

et al. 2018

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“…As a traditional Chinese medical therapy, EA is shown to be a beneficial treatment for several diseases including stress urinary incontinence, knee osteoarthritis, and acute ischemic cerebral apoplexy in clinical studies ( 23 – 25 ). Notably, EA significantly reduced myocardial injury induced by cardiac hypertrophy and ischemic insult in animal models and clinical studies ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway

Wang

et al. 2021

Front. Cardiovasc. Med.

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Myocardial ischemia/reperfusion injury is a common clinical problem and can result in severe cardiac dysfunction. Previous studies have demonstrated the protection of electroacupuncture against myocardial ischemia/reperfusion injury. However, the role of X-box binding protein I (XBP1) signaling pathway in the protection of electroacupuncture was still elusive. Thus, we designed this study and demonstrated that electroacupuncture significantly improved cardiac function during myocardial ischemia/reperfusion injury and reduced cardiac infarct size. Electroacupuncture treatment further inhibited cardiac injury manifested by the decrease of the activities of serum lactate dehydrogenase and creatine kinase-MB. The results also revealed that electroacupuncture elevated the expressions of XBP1, glucose-regulated protein 78 (GRP78), Akt, and Bcl-2 and decreased the Bax and cleaved Caspase 3 expressions. By using the inhibitor of XBP1 in vitro, the results revealed that suppression of XBP1 expression could markedly increase the activities of lactate dehydrogenase and creatine kinase-MB and cell apoptosis, thus exacerbating stimulated ischemia/reperfusion-induced H9c2 cell injury. Compared with stimulated ischemia/reperfusion group, inhibition of XBP1 inhibited the downstream GRP78 and Akt expressions during stimulated ischemia/reperfusion injury. Collectively, our data demonstrated that electroacupuncture treatment activated XBP1/GRP78/Akt signaling to protect hearts from myocardial ischemia/reperfusion injury. These findings revealed the underlying mechanisms of electroacupuncture protection against myocardial ischemia/reperfusion injury and may provide novel therapeutic targets for the clinical treatment of myocardial ischemia/reperfusion injury.

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“…Several studies have reported various effects of EA, and EA has been used to effectively treat migraine [ 20 ], obesity [ 21 ], cerebral infarction [ 22 , 23 ], and tinnitus [ 5 ]. Most of these studies used EA combined with systemic manual acupuncture [ 5 , 20 , 21 ]; however, according to the Traditional Chinese Medicine meridian system theory, the body is an organic structure connected by meridians, meaning that several acupoints have a similar treatment effect not only in the target area but also in the upper and lower limbs.…”

Section: Discussionmentioning

confidence: 99%

A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

Kim

Nam

2017

BMC Complement Altern Med

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BackgroundMany previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the effects of systemic manual acupuncture, periauricular electroacupuncture and distal electroacupuncture for treating patients with tinnitus.MethodsA randomized, parallel, open-labeled exploratory trial was conducted. Subjects aged 20–75 years who had suffered from idiopathic tinnitus for > 2 weeks were recruited from May 2013 to April 2014. The subjects were divided into three groups by systemic manual acupuncture group (MA), periauricular electroacupuncture group (PE), and distal electroacupuncture group (DE). The groups were selected by random drawing. Nine acupoints (TE 17, TE21, SI19, GB2, GB8, ST36, ST37, TE3 and TE9), two periauricular acupoints (TE17 and TE21), and four distal acupoints (TE3, TE9, ST36, and ST37) were selected. The treatment sessions were performed twice weekly for a total of eight sessions over 4 weeks. Outcomes were the tinnitus handicap inventory (THI) score and the loud and uncomfortable visual analogue scales (VAS). Demographic and clinical characteristics of all participants were compared between the groups upon admission using one-way analysis of variance (ANOVA). One-way ANOVA was used to evaluate the THI, VAS loud, and VAS uncomfortable scores. The least significant difference test was used as a post-hoc test.ResultsThirty-nine subjects were eligible and their data were analyzed. No difference in THI and VAS loudness scores was observed in between groups. The VAS uncomfortable scores decreased significantly in MA and DE compared with those in PE.Within the group, all three treatments showed some effect on THI, VAS loudness scores and VAS uncomfortable scores after treatment except DE in THI.ConclusionsThere was no statistically significant difference between systemic manual acupuncture, periauricular electroacupuncture and distal electroacupuncture in tinnitus. However, all three treatments had some effect on tinnitus within the group before and after treatment. Systemic manual acupuncture and distal electroacupuncture have some effect on VAS uncomfortable.Trial registration KCT0001991 by CRIS (Clinical Research Information Service), 2016-8-1, retrospectively registered.

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Clinical curative effect of electric acupuncture on acute cerebral infarction: a randomized controlled multicenter trial

Cited by 20 publications

References 2 publications

Retraction: Effect of Acupuncture and Chinese Herbal Medicine on Subacute Stroke Outcomes: A Single Center Randomized Controlled Trial

Retraction: Effect of Acupuncture and Chinese Herbal Medicine on Subacute Stroke Outcomes: A Single Center Randomized Controlled Trial

Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway

A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

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