Clinical Courses of Graft Failure Caused by Chronic Allograft Dysfunction in Kidney Transplantation

Fujiwara, Toru; Teruta, Shoma; Tsudaka, Shimpei; Ota, Kosuke; Matsuda, Hiroaki

doi:10.1016/j.transproceed.2016.11.013

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Chronic allograft dysfunction (CAD) is a progressive and irreversible entity and is a cause of long-term kidney transplant failure [1][2][3]. The mechanisms of damage that contribute to CAD involve immunological [4] and nonimmunological [3] aspects, which conditions the formation of interstitial fibrosis and tubular atrophy (IFTA) [5].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

Andrade‐Sierra

Morales-Guillén

García-Sánchez

et al. 2022

Oxidative Medicine and Cellular Longevity

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The clinical and biochemical improvement observed in kidney transplant (RT) recipients is remarkable. The correct functioning of the allograft depends on various factors such as the donor’s age, the alloimmune response, the ischemia-reperfusion injury, arterial hypertension, and the interstitial fibrosis of the allograft, among others. Antihypertensive drugs are necessary for arterial hypertension patients to avoid or reduce the probability of affecting graft function in RT recipients. Oxidative stress (OS) is another complex pathophysiological process with the ability to alter posttransplant kidney function. The study’s objective was to determine the effect of the administration of Enalapril, Losartan, or not antihypertensive medication on the oxidative state in RT recipients at the beginning of the study and one year of follow-up. All patients included in the study found significant overexpression of the oxidative damage marker to DNA and the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). In contrast, it was found that the determination of the total antioxidant capacity decreased significantly in the final determination at one year of follow-up in all the patients who ingested Enalapril and Losartan. We found dysregulation of the oxidative state characterized mainly by oxidative damage to DNA and a significant increase in antioxidant enzymes, which could suggest a compensatory effect against the imbalance of the oxidative state.

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Section: Introductionmentioning

confidence: 99%

The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

Andrade‐Sierra

Morales-Guillén

García-Sánchez

et al. 2022

Oxidative Medicine and Cellular Longevity

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Biomarkers and Pharmacogenomics in Kidney Transplantation

Crowley

Chand

2018

Mol Diagn Ther

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This review is focused on present and future biomarkers, along with pharmacogenomics used in clinical practice for kidney transplantation. It aims to highlight biomarkers that could potentially be used to improve kidney transplant early and long-term graft survival, but also potentially patient co-morbidity. Future directions for improving outcomes are discussed, which include immune tolerance and personalising immunosuppression regimens.

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Frequency of Human Leukocyte Antigens and Donor Specific Antibodies in Long-Term Living Donor Kidney Transplantation

Alagöz

Seyahi

2019

Transplantation Proceedings

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Clinical Courses of Graft Failure Caused by Chronic Allograft Dysfunction in Kidney Transplantation

Cited by 3 publications

References 12 publications

The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

The Effect of Enalapril, Losartan, or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

Biomarkers and Pharmacogenomics in Kidney Transplantation

Frequency of Human Leukocyte Antigens and Donor Specific Antibodies in Long-Term Living Donor Kidney Transplantation

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