Clinical course of lung cancer in patients with chronic kidney disease

Patel, Purvi; Henry, Lisa; Ganti, Apar Kishor; Potti, Anil

doi:10.1016/j.lungcan.2003.08.029

Cited by 22 publications

(28 citation statements)

References 9 publications

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“…Interestingly, the survival rate was lower in CKD among those with cancer except lung and breast cancer. Our results were similar to previously published data [17]. They reported that patients with CKD and lung cancer have a similar clinical course and survival as compared to those with lung cancer and without CKD because of relative rapid progression.…”

Section: Discussionsupporting

confidence: 92%

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Na¹,

Sung²,

Chang³

et al. 2011

Am J Nephrol

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Background/Aims: The effects of chronic kidney disease (CKD) on the risk of death for patients with malignant disease are uncertain. The aim of this study was to determine the association between the presence of CKD and mortality in cancer patients. Method: We retrospectively reviewed the cases of 8,223 cancer patients with one or more serum creatinine measurements from January 1, 2000 to December 31, 2004. The key outcome was cancer-specific mortality within the follow-up period. The cumulative incidence rate for death from cancer was estimated using methods of competing risks survival analysis. Cox proportional-hazards regression with the use of Fine and Gray’s proportional-hazards model were evaluated in multiple analyses. Results: CKD was associated with an increased risk of death in cancer patients. The adjusted hazard ratios were 1.12 for patients with an estimated glomerular filtration rate (eGFR) of 30–59 ml/min/1.73 m² (95% confidence interval 1.01–1.26, p = 0.04) and 1.75 for patients with an eGFR <30 ml/min/1.73 m² (95% confidence interval 1.32–2.32, p < 0.001). Conclusions: CKD should be considered a risk factor for survival among patients with cancer.

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Section: Discussionsupporting

confidence: 92%

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Na¹,

Sung²,

Chang³

et al. 2011

Am J Nephrol

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“…Interestingly, our finding demonstrating worse outcomes with moderate or severe liver disease (HR, 3.736; 95% CI, 1.088-12.826) and dementia (HR, 2.332; 95% CI, 1.202-4.524) in regional stage lung cancer corresponded to the inconsistent impact of dementia and liver disease on survival across stages found by other studies (4). Renal disease was reported as having a universal impact on survival in both early-and advanced lung cancer in others studies (22), but the impact on early-stage lung cancer was much higher compared with advanced stage lung cancer (HR, 2.74 in early stage;1.42 in advanced stage; 4). In the current study, we also found this kind of change in survival impact for renal disease (regional HR, 1.44; 95% CI, 1.1-1.88; distant HR, 1.11).…”

Section: Discussionmentioning

confidence: 92%

Comorbidity and Survival in Lung Cancer Patients

Islam

Jiang

Anggondowati

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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157

118

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Background: As the population of the United States ages, there will be increasing numbers of lung cancer patients with comorbidities at diagnosis. Comorbid conditions are important factors in both the choice of the lung cancer treatment and outcomes. However, the impact of individual comorbid conditions on patient survival remains unclear.Methods: A population-based cohort study of 5,683 first-time diagnosed lung cancer patients was captured using the Nebraska Cancer Registry (NCR) linked with the Nebraska Hospital Discharge Data (NHDD) between 2005 and 2009. A Cox proportional hazards model was used to analyze the effect of comorbidities on the overall survival of patients stratified by stage and adjusting for age, race, sex, and histologic type.Results: Of these patients, 36.8% of them survived their first year after lung cancer diagnosis, with a median survival of 9.3

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“…In addition, it has been confirmed that lung cancer and CKD may have a similar course and survival in comparison with the patients with lung cancer without CKD, which it means that these two diseases could receive the same benefit from treatment (24). However, it has also approved that CKD could not be an independent risk factor for survival in patients with lung cancer (25).…”

Section: Lung Cancer and Kidneymentioning

confidence: 99%

Impact of cancers on the kidney function and structure; an ignored entity

Davoodi¹,

Bahadoram²,

Bahadoram³

et al. 2018

J Renal Inj Prev

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Important declines have been observed in urological cancer-related mortality in recent decades, mainly due to improvements in treatments of prostate cancer, less exposure to tobacco smoking as well as occupational carcinogens of kidney and bladder. However, because of global population ageing, age-related urinary tract cancers are expected to increase in the near future despite improved primary prevention, early detection and more efficient treatment. In this article, renal cell carcinoma (RCC), kidney transplantation, cancer and acute kidney injury (AKI), lung cancer and chronic kidney disease (CKD), breast cancer, prostate cancer, cervix cancer and brain cancer and their associations with kidney function and structure have been discussed. In conclusion, kidney and cancers have interaction with each other. Kidney carcinoma can be metastasizing to other organs as well as other cancer to kidney. Therefore, it is recommended to consider the potential effect of kidney functions and interaction with other cancers in each malignancy.

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Clinical course of lung cancer in patients with chronic kidney disease

Cited by 22 publications

References 9 publications

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Chronic Kidney Disease in Cancer Patients: An Independent Predictor of Cancer-Specific Mortality

Comorbidity and Survival in Lung Cancer Patients

Impact of cancers on the kidney function and structure; an ignored entity

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