Clinical course of dengue fever and its impact on renal function in renal transplant recipients and patients with chronic kidney disease

Thomas, E T Arun; George, Jacob; Sruthi, D.; Vineetha, Nalanda S.; Gracious, Noble

doi:10.1111/nep.13265

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Pathophysiological consequences of dengue infection, especially plasma leakage leading to reduced intravascular volume could aggravate already compromised renal function and would challenge fluid and electrolyte management, not only in patients with CKD but also in those with CHF. 30 The analysis, contrary to expectations, did not find an association between chronic hepatitis and the adverse outcomes that we explored. Elevations in hepatic transaminases and acute hepatitis frequently occur during acute dengue, to the point that acute liver failure in dengue has been managed with liver transplantation.…”

Section: Discussioncontrasting

confidence: 84%

A Population-Based Cohort Study on Chronic Comorbidity Risk Factors for Adverse Dengue Outcomes

Lien

Chou

Shen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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The global burden of dengue is increasing against a background of rising global prevalence of chronic noncommunicable diseases (NCDs) and an epidemiological shift of dengue toward older age groups. The contribution of NCDs toward risk for adverse clinical and healthcare utilization outcomes was assessed in a national linked-database study. About 51,433 adult dengue cases between 2014 and 2015 were assessed for outpatient and inpatient claims data in Taiwan’s National Health Insurance Research Database for the 30 days after their dengue diagnosis. A multivariable logistic regression with generalized estimating equations was used to estimate the probability of adverse dengue outcomes in patients with NCDs compared with dengue patients without underlying diseases. Rheumatoid arthritis and related disease were associated with the highest risk of hospitalization after dengue diagnosis (odds ratio: 1.78; 95% CI: 1.37–2.30), followed by stroke, chronic kidney disease (CKD), liver cirrhosis, asthma, coronary artery disease, chronic obstructive pulmonary disease, diabetes, congestive heart failure, hypertension, and malignancy. Chronic kidney disease and diabetes were associated with higher risks of hospitalization, intensive care unit (ICU) use, and all-cause mortality. After adjusting for socioeconomic status and other variables, the number of coexisting chronic diseases was associated with increasing risk of adverse dengue outcomes. Specific NCDs were associated with longer hospitalizations, ICU admission, and higher healthcare costs. Quantifying the risks of adverse dengue outcomes and health expenditures among dengue patients with preexisting NCDs provides insights for improved clinical management and essential inputs for health economic analyses on the cost-benefit of risk-based routine or catch-up immunization programs.

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Section: Discussioncontrasting

confidence: 84%

A Population-Based Cohort Study on Chronic Comorbidity Risk Factors for Adverse Dengue Outcomes

Lien

Chou

Shen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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“…Patients with Chronic Kidney Disease (CKD) are also at an increased risk of severe DF or mortality. DF often causes acute kidney injury due to the hemorrhagic shock state, rhabdomyolysis and glomerulonephritis that can be produced by the virus, thus, patients with CKD are more prone to that kidney damage (Mallhi et al, 2017b;Thomas et al, 2019). Other pathophysiological mechanism that can explain this risk in patients with CKD can be secondary to inadequate production of immune mediators by infected mononuclear cell, (Lee et al, 2019) As for the increased risk associated with young age, compared to adults, children are more prone to vascular fragility and reduced capillary perfusion, predisposing them to plasma leakage, hemoconcentration and thrombocytopenia, reflecting low volume status (Lovera et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for hospitalization and mortality due to dengue fever in a Mexican population: a retrospective cohort study

Fonseca-Portilla

Martínez-Gil

Morgenstern-Kaplan

2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…6,7 The few available studies suggest that the initial symptoms of dengue-infected transplant recipients is identical across cases. 8,9 A systematic review from 2017 found a higher incidence of severe dengue fever and a higher mortality rate (of up to 8.9%) in patients who contracted the virus through transplantation. 10 The review also found that more than 60% of transplanted patients had transient renal dysfunction, and 6.5% had graft loss.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Transmission of Dengue Virus from a Deceased Donor to a Kidney Transplant Recipient Previously Infected by Dengue Virus

Lecadieu

Teysseyre

Larsen

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Since 2018, a dengue epidemic has been ongoing in the French overseas department of Reunion Island, in the Indian Ocean, with more than 25,000 serologically confirmed cases. Currently, three dengue serotypes have been identified in Réunion Island (DENV-1, DENV-2, and DENV-3) progressing in the form of epidemic outbreaks. This arbovirus is mainly transmitted by mosquitoes of the genus Aedes and may be responsible for serious clinical forms. To date, very few cases of kidney transplant–related dengue virus infection have been described. Here we report the first case of severe dengue virus infection related to kidney transplantation from a patient previously infected with dengue. Testing for dengue fever with PCR search in donor’s urine may help complete the pretransplant assessment in areas where this disease occurs.

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Clinical course of dengue fever and its impact on renal function in renal transplant recipients and patients with chronic kidney disease

Abstract: Clinical features of dengue fever were different in renal transplant recipients and patients with CKD. Severe worsening of renal function was common in CKD patients. Worsening of renal function in renal transplant recipients was less severe and transient.

Cited by 17 publications

References 22 publications

A Population-Based Cohort Study on Chronic Comorbidity Risk Factors for Adverse Dengue Outcomes

A Population-Based Cohort Study on Chronic Comorbidity Risk Factors for Adverse Dengue Outcomes

Risk factors for hospitalization and mortality due to dengue fever in a Mexican population: a retrospective cohort study

Case Report: Transmission of Dengue Virus from a Deceased Donor to a Kidney Transplant Recipient Previously Infected by Dengue Virus

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