Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status

Saarinen, Kimmo; Pelkonen, Antti; Mäkelä, Mika J.; Savilahti, Erkki

doi:10.1016/j.jaci.2005.06.018

Cited by 258 publications

(275 citation statements)

References 28 publications

(53 reference statements)

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“…114 Further studies with crude allergen extracts mostly verified a general trend of a correlation between high sIgE titers and slow outgrowth of cow's milk or hen's egg allergy. [115], [116], [117], [118] and [119] Yet again a significant overlap in serum sIgE reactivity of patients with early and late outgrowth was apparent. However, systematic studies with recombinant food allergens as sensitivity-improved test agents in quantitative sIgE determinations are still lacking.…”

Section: Quantification Of Ige Antibodiesmentioning

confidence: 99%

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Steckelbroeck¹,

Ballmer‐Weber²,

Vieths³

2008

Journal of Allergy and Clinical Immunology

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This article aims to critically review developments in food allergy diagnostics with regard to the verification of specific IgE antibodies and the identification of the responsible allergens. Results of IgE-binding tests with food extracts are hampered by cross-reactive proteins, low-quality test agents, or both. Specificity can be increased by defining adequate cutoff values, whereas sensitivity can be improved by using high-quality test agents. IgE-binding tests with purified allergens enabled reliable quantification of allergen-specific IgE titers, with higher levels found in individuals with food allergy compared with individuals without food allergy. However, the overlap in individual test reactivity between allergic and nonallergic subjects complicates interpretation. Recombinant allergens and synthetic sequential epitopes enabled detection of sensitization profiles, with IgE specific to several allergens and substructures now being suggested as markers of severity, persistence, or both. However, high-power quantitative studies with larger numbers of patients are required to confirm these markers. This article aims to critically review developments in food allergy diagnostics with regard to the verification of specific IgE antibodies and the identification of the responsible allergens. Results of IgE-binding tests with food extracts are hampered by cross-reactive proteins, low-quality test agents, or both. Specificity can be increased by defining adequate cutoff values, whereas sensitivity can be improved by using high-quality test agents. IgE-binding tests with purified allergens enabled reliable quantification of allergen-specific IgE titers, with higher levels found in individuals with food allergy compared with individuals without food allergy. However, the overlap in individual test reactivity between allergic and nonallergic subjects complicates interpretation. Recombinant allergens and synthetic sequential epitopes enabled detection of sensitization profiles, with IgE specific to several allergens and substructures now being suggested as markers of severity, persistence, or both.However, high-power quantitative studies with larger numbers of patients are required to confirm these markers. IgE-mediated and non-IgE-mediated syndromes, where IgE-mediated manifestations are responsible for the majority of food-induced, immediate-type, immune-mediated hypersensitivity reactions. 3 The development of an IgE-mediated response to food requires a series of molecular and cellular interactions, which involve antigenpresenting cells, T lymphocytes, and B lymphocytes. [4] and [5] Depending on the route of sensitization, food allergy is the result of either genuine reactivity to comestibles through the gastrointestinal tract (class I food allergens) or secondary sensitization to cross-reactive food allergens as a consequence of the initial reactivity to homologous pollen-related allergens (class II food allergens). [6] and [7] The majority of class I food allergens are heat stable and resistan...

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Section: Quantification Of Ige Antibodiesmentioning

confidence: 99%

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Steckelbroeck¹,

Ballmer‐Weber²,

Vieths³

2008

Journal of Allergy and Clinical Immunology

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“…Although resolution of CMA in 87% of children by 3 years of age has been reported, 3 more recent evidence suggests persistence of allergy until adolescence in 15% of cases. 4,5 The deleterious impact of CMA on bone mineral density (BMD) has been documented in small cohorts of children and adolescents, 6,7 probably resulting from deprivation of key bone nutrients during a period of intensive skeletal growth.…”

mentioning

confidence: 99%

Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children

Mailhot

Perrone²,

Alos

et al. 2016

Pediatrics

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BACKGROUND AND OBJECTIVES: Recent data suggest that cow's milk allergy (CMA) has become more persistent, prolonging treatment via strict elimination of cow's milk products into a period of skeletal growth. The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of calcium and vitamin D between prepubertal children with persistent CMA and those with non-cow's milk food allergies (NCMA) as control subjects and to assess the use of and compliance to calcium and vitamin D supplementation among children with persistent CMA.

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“…[24][25] most children with egg allergy are also likely to develop egg tolerance by late childhood, with the exception of patients with an egg IgE greater than 50 kU L, who are unlikely to develop egg tolerance. [26] Peanut, sesame seeds and tree nuts allergies are more persistent with a chance of becoming tolerant is about 20% for peanut and sesame seeds and about 10% for tree nuts.…”

Section: Epidemiologymentioning

confidence: 99%

The Progress of Food Allergy Concept, Classifications and Diagnosis

Kamal-Alahmad¹

2016

IJNFS

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Food allergies, defined as an immune response to food proteins, affect as many as 8% of young children and 5% of adults in most countries, and their prevalence appears to be rising like all allergic diseases, In addition to well-recognized urticaria and anaphylaxis triggered by IgE antibody-mediated immune responses. Food allergy is a rapidly growing public health concern because of its increasing prevalence and life-threatening potential. Food allergic reaction can be further subdivided into IgE mediated and non IgE mediated. The diagnosis of food allergy is made from the history, supported by investigations and by responses to avoidance of specific food triggers. So in this work we want to introduce some concepts in food allergy such as classification of allergic and diagnosis of food triggers and finally how to manage this problem and minimize the prevalence of food allergy.

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Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status

Cited by 258 publications

References 28 publications

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children

The Progress of Food Allergy Concept, Classifications and Diagnosis

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