Clinical course and longterm prognosis of Japanese patients with Crohn?s disease: predictive factors, rates of operation, and mortality

Abstract

CD patients with colitis type showed a better clinical course and had significantly different clinical features compared with the patients with ileitis and ileocolitis type. Prediction of the longterm course of CD is possible by using clinical factors during the first year after starting treatment. The relative survival rates in Japanese patients with CD are not different from those seen in Western countries. The purpose of this study was to clarify the long-term course of Crohn's disease (CD) and predictors of its prognosis in Japan.

Inflammatory Bowel Disease in Korea: Epidemiological, Genomic, Clinical, and Therapeutic Characteristics

“…1 This finding is similar to that reported by a Japanese study. 57 This contrasts with recent European studies that reported isolated colonic disease as the most common type of CD at diagnosis. 29,58 In a genetic polymorphism study with a large number of Northern European and Korean patients with CD and normal controls, CARD15 (NOD2) mutations were not found to be associated with susceptibility to CD in Korean patients, although they were in European populations.…”

Crohn’s disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan

“…These findings suggest that long-term follow-up of 20 years or longer may show a decrease in cumulative survival among CD patients. Table 6 shows SMRs for all causes from previous hospital-based studies [5,6,14,[21][22][23][24][25]. Prior et al [21] and Weterman et al [22] reported high SMRs, but recent reports did not find increased SMRs.…”

“…It has recently been reported that mortality is similar or slightly higher in CD patients than in the general population [5][6][7][8][9][10][11][12][13][14]. However, most data are derived from population-based studies, which are considered not conducive to patient follow-up or detailed investigation of the causes of deaths, and there are very few, long-term, hospital-based studies with a large sample size [5,6,14,[21][22][23][24][25]. Therefore, this hospital-based cohort study was conducted at a tertiary referral center in Japan to investigate survival, cause of death, and factors that affect mortality of CD patients in detail.…”

“…It is also known to frequently require intestinal resection due to the development of intestinal complications such as stenosis and fistula through repeated relapses or recurrences [1][2][3][4]. Although there are some reports of the long-term course of patients with this disease, there are very few reports related to their survival and cause of death; moreover, most previous reports are derived from population-based cohort studies, and there are very few, long-term, hospital-based, cohort studies with a long duration of follow-up and a large sample size [5][6][7][8][9][10][11][12][13][14]. In the present study, a database based on the medical records of CD patients at our hospital with the addition of information obtained from a questionnaire survey was created, and the long-term prognosis of CD patients was investigated.…”

Analysis of Epidemiological and Clinical Characteristics of Inflammatory Bowel Disease over 15- year period

“…The colectomy rate of CD in our investigation showed a significant decreasing tendency from 32.3% in the period of 1995-2004 to 18.4% in 2005-2009, which was lower than the studies in Japan and western countries. A recent Japanese study reported that the cumulative colectomy rate of CD was 37.6%, 60.4% and 74.2% at 5, 10 and 15 years after the onset of symptoms, respectively [25]. In South-Eastern Norway, 28% of CD patients underwent intestinal resection during the 5 years follow up [26].…”