Clinical Correlations of Patterns of Placental Pathology in Preterm Pre-eclampsia

Hematologic effects of placental pathology on very low birthweight infants born to mothers with preeclampsia

“…In addition, lower birthweight percentiles and lighter placentas were directly associated with uteroplacental vascular lesions. 19 Ghidini's 11 prospective study used a scoring system based on severity and extent of placental vascular and villous lesions and found that the clinical diagnosis of preeclampsia increased with progressive uteroplacental impairment. The lesions defined in Ghidini's study were analyzed for more specific lesions than is typically found in a standard placental pathology report and could not be applied to this study.…”

Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia

“…4,5 Although the pathogenesis of PE is poorly understood, it has been speculated that abnormal placentation is the primary cause of the disease. [6][7][8] In PE, cytotrophoblasts invasion is incomplete, which is supported by the observation that cytotrophoblast cells are only present in the superficial layers of the deciduas. 9 In addition, a high-resistance uteroplacental circulation is visible on pathological examination of preeclamptic placentas, which results from failed invasion and remodeling of cytotrophoblasts to the spiral arteries.…”

Placental Vascular Pathology Findings and Pathways to Preterm Delivery

“…Another has been to group multiple placental findings to characterize globally defined vascular complications such as abnormal placentation, uteroplacental ischemia, and hemorrhage, but across studies there are considerable inconsistencies in terminology, definitions, and findings used (Table 1). Few studies have empirically evaluated placental vascular findings to determine how often they co-occur (22,23), and only 1 of these studies used both term and preterm placentas (22). Finally, investigators have primarily concentrated on maternal vascular pathology in relation to preterm delivery, so less is known about the influence of fetal vascular findings, alone or in combination with maternal vascular pathology (24)(25)(26).…”