Clinical correlates of response to DST

Gastpar, Markus; Gilsdorf, U; Abou‐Saleh, Mohammed T.; Ngo-Khac, Trunc

doi:10.1016/0165-0327(92)90030-a

Cited by 10 publications

(1 citation statement)

References 8 publications

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“…However, this condition is not strictly confined to affective disorders, but seems to involve a wider group of psychiatric patients, psychotic or not, often characterized by acute presentations, frequently associated with symptoms of agitation [40]. Therefore many immune system dysfunctions present in psychiatric patients belonging to different diagnostic areas, could share this common underlying functional mechainism.…”

Section: Discussionmentioning

confidence: 99%

Anti-Purkinje Cell and Natural Autoantibodies in a Group of Psychiatric Patients. Evidences for a Correlation with the Psychopathological Status

Chiaie¹,

Caronti²,

Macrì³

et al. 2012

CPEMH

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Phenomena of autoimmunity are frequent among psychiatric patients, but we don’t know yet if they should be considered primary and linked to the pathophisiology of the disorder, or aspecific and associated to a general immune system activation. Paraneoplastic Cerebellar Degeneration (PCD) represents a well known model of specific autoimmunity. In order to better understand the abovementioned issues, we used this condition to compare a set of immune dysfunctions found in a group of psychiatric patients. For this reason we tested sera from 48 psychiatric patients (24 schizophrenics, 17 bipolars and 7 obsessive-compulsive), 22 PCD patients and 52 healthy controls for the presence of anti-Purkinje autoantibodies and of some natural autoantibodies (ANAs, AMAs, APCAs, ASMAs). Psychopatological status of the psychiatric patients was assessed with BPRS, SANS, SAPS, HAM-D, CGI-S. In the psychiatric group anti-Purkinje autoantibodies were identified in 11/48 (22,9%) patients, while they were present in 22/22 (100%) PCD patients and in 0/52 (0%) healthy controls. Among all anti-Purkinje autoantibody positive patients (in the PCD and psychiatric samples), only those belonging to the psychiatric sample, but not those with PCD, were frequently found positive also for natural autoantibodies, that are considered good markers of aspecific immune activation. In these patients, both anti-Purkinje and natural autoantibodies were found associated with acute/positive psychopathological symptoms. These results seem to point out that some phenomena of auto-immunity described in psychiatric patients could be aspecific, unrelated to the pathophysiology of the concomitant mental disorders and could be more frequent during phases of acute/positive symptoms.

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Section: Discussionmentioning

confidence: 99%