Clinical correlates and outcome of Shoshin Beriberi

Saya, Rama Prakasha; Baikunje, Shashidhar; Prakash, Patil; Subramanyam, K.; Patil, Veeresh

doi:10.4103/1947-2714.102003

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…Thiamine deficiency has been reported as the etiology for acute cardiac failure presenting as cardiogenic shock in different case reports. 4 5 6 Acute thiamine deficiency has also been associated with other lesser known presentations including, as in our case and others described below, lactic acidosis.…”

Section: Introductionsupporting

confidence: 79%

Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report

Didisheim

Ballhausen

Choucair³

et al. 2020

J Pediatr Intensive Care

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We present a teenager, in maintenance chemotherapy for leukemia, who was admitted for digestive symptoms related to a parasitic infection and required nutritional support with parenteral nutrition. After 6 weeks, his condition worsened with refractory shock of presumed septic origin, necessitating extracorporeal membrane oxygenation. Despite hemodynamic stabilization, his lactic acidosis worsened until thiamine supplementation was started. Lactate normalized within 12 hours. Thiamine is an essential coenzyme in aerobic glycolysis, and deficiency leads to lactate accumulation through anaerobic glycolysis. Thiamine deficiency is uncommon in the pediatric population. However, it should be considered in patients at risk of nutritional deficiencies with lactic acidosis of unknown origin.

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Section: Introductionsupporting

confidence: 79%

Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report

Didisheim

Ballhausen

Choucair³

et al. 2020

J Pediatr Intensive Care

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“…Cancer, prior bariatric surgery, malabsorption due to gastrointestinal disease, parenteral nutrition, starvation and malnutrition are also risk factors for thiamine deficiency, although these patient populations were not the focus of the present study (5). While not the focus of guidelines, an additional concern in critically ill subjects with thiamine deficiency would include cardiovascular and gastrointestinal beriberi which has a presentation similar to other underlying critically ill states such as sepsis and will result in death if unrecognized (21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness

et al. 2022

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“…Within hours, even infants with advanced beriberi return to breastfeeding and, within days, their cardiac function returns to normal. Shoshin beriberi is a fulminant form of wet beriberi (acute cardiogenic shock with lactic acidosis multiorgan failure and no edema) and can easily mimic sepsis . Because of uncertainties regarding the diagnostic criteria of TDDs, it may only be possible to diagnosis beriberi after a patient demonstrates significant improvement following treatment with thiamine.…”

Section: Thiamine Deficiency and Its Consequencesmentioning

confidence: 99%

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Whitfield

Bourassa

Adamolekun

et al. 2018

Annals of the New York Academy of Sciences

228

335

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Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.

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Clinical correlates and outcome of Shoshin Beriberi

Cited by 12 publications

References 14 publications

Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report

Severe Lactic Acidosis in a Critically Ill Child: Think About Thiamine! A Case Report

Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

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