Clinical Comparison of the Caries Inhibition of Two Mixed NaF-Na₂PO₃F Dentifrices Containing 1,000 and 2,500 ppm F Compared to a Conventional Na₂PO₃F Dentifrice Containing 1,000 ppm F: Results after Two Years

Abstract

The 2-year caries increments of fifth to seventh grade students (mean age 11.7 years) residing in two fluoride-deficient communities (F < 0.1 ppm) on Long Island, N.Y., were compared relative to their use of different fluoride dentifrices. Group I used a conventional Na₂PO₃F dentifrice (1,000 ppm F) and served as the positive control. Group II used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na₂PO₃F which provided a total fluoride concentration of 1,000 ppm. Group III also used a mixed fluoride dentifrice containing equimolar amounts of NaF and Na₂PO₃F with a total fluoride concentration of 2,500 ppm. Brushing was performed unsupervised at home for 23 months. There were no statistically significant differences (F test) in the 2-year caries increments between the dentifrice groups for DMFT, DMFS, and DMFS of specific tooth surface types. Mitigating factors which may have influenced the results were the low proximal caries increments and the degree of compliance. Use of a mixed fluoride dentifrice (NaF/Na₂PO₃F) at a standard 1,000 ppm F concentration or at 2.5 times standard did not provide superior caries inhibition compared to a conventional Na₂PO₃F dentifrice containing 1,000 ppm F.

Salivary levels of Streptococcus mutans and lactobacilli and dental caries experiences in a US adolescent population

“…For example, if one uses a S. mutans CFU count greater than 10\ the sensitivity and specificity are 33% and 81%, respectively; using a CFU count greater than lO'' for lactobacilli produces a sensitivity and specificity of 45% and 81%, respectively. LACTOBACILLI distribution of lactobacilli at the initial (BL) and 17-month (follow-up) DMFS (annualized) is low compared with those typically realized in US nonfiuoridated communities as recently as the late 197O's (17), but appears consistent with those currently being reported in the US (18)(19)(20). This decreased level of caries activity makes it more difficult to demonstrate associations with caries incidence, especially on an individual subject basis.…”

A 3‐year oral health dose‐response study of sodium monofluoro‐phosphate dentifrices with and without zinc citrate: anti‐caries results

“…Sinee the trial commenced in 1983, further reports have been published relating to toothpastes with different fluoride concentrations. In these, MITROPOULOS et al (7), DiODATi et al, (8), and TRIOL et al (9) showed significant dose-response relationships, whereas RIPA et al (10) reported no such effect.…”

Caries-Preventive Effect of Dentifrices Containing Various Types and Concentrations of Fluorides and Sugar Alcohols

“…For several decades fluorides (F) have been avail able in toothpastes, and today almost all products used in the industrialized countries contain up to 1,000 ppm F, or even more [Forward, 1980;Stookey, 1985;Ripa et al, 1987], Ericsson and Forsman [1969] suggested that toothpastes with either sodium F (NaF) or sodium monofluorophosphate (MFP) should con tain less than 0.1% F if used by children of tooth-min eralizing ages. Since F in toothpaste is known to have a high bioavailability [Ekstrand and Ehrnebo, 1980;Ekstrand et al, 1983], the risk of an increase in dental fluorosis from too high a daily F intake should be taken into consideration [Barnhart et al, 1974;Hei fetz and Horowitz, 1984;Beltran, 1988;Bruun and Thylstrup, 1988].…”