Clinical comparison of botulinum toxin in motor and autonomic disorders: Similarities and differences

Clinical duration of action of different botulinum toxin types in humans

“…Different clinical studies confirm that the effective clinical dose of Rima for the treatment of cervical dystonia is higher than the dosage of Ona (Brashear et al, 1999;Brin et al, 1999), similarly when the clinicians desire to treat autonomic disorders, even if in a less ratio (Naumann, 2015;Petracca et al, 2015).…”

“…In secretory disorders, BoNT/B appear effective and generally injected at lower doses when compared to neuro-muscular diseases, even if with a dose ratio different from others autonomic diseases. Nevertheless, equivalent effect of BoNT/A is reported on autonomic system, without any major clinical advantage for the patients after injections of BoNT/B (Bentivoglio et al, 2015;(Naumann, 2015). Further clinical trials are warranted to better clarify the role of different BoNT serotypes in different autonomic clinical indications.…”

“…These authors detected also some differences in gender (less effective in women) for each serotypes and concluded that the BoNT/A/BoNT/B ratio could be considered 1:29 (Kranz et al, 2011). Nevertheless, large comparative long-term clinical trials to evaluate the effects of these different serotypes in autonomic fibers are not yet available (Naumann, 2015).…”