Clinical characterization of influenza A and human respiratory syncytial virus among patients with influenza like illness

Abstract

Influenza A and Respiratory Syncytial Virus (RSV) has been recognized as a major cause of acute respiratory tract infection. H1N1 is one of the subtypes of influenza A, pandemic worldwide in July 2009, causing 18,449 deaths globally. To investigate the prevalence and clinical manifestation of the influenza A, H1N1pdm09, and RSV. Throat/nasal swab collected from the patients of all age group either outpatients/inpatients having respiratory illness from 2 to 5 days. The clinical data were recorded in a predesigned questionnaire. RNA was extracted and analyzed by real time PCR at a tertiary care center, 2009-2014. Total 4,352 samples tested for influenza A and H1N1. Out of 4,352, 32.2% (median positivity 21%; range 16-41% during 6 years) were positive for influenza A and 19% were H1N1 (median positivity 16.7%; range 8.7-23% during 6 years). Total 1653 samples were analyzed for RSV from 2011 to 2014, 12% were RSV positive (median positivity 11.35%; range 10-16.3% during 4 years). Pharyngitis, dyspnea were frequent symptoms in influenza A and H1N1 (P < 0.005) whereas bronchiolitis and pneumonia were commonly present in RSV (P < 0.005). The positivity of influenza A and H1N1 was higher in age-group 21-30, whereas RSV in infant and children. H1N1 and RSV were co-circulated and have common clinical symptoms particularly in lower age group. Therefore, laboratory confirmation is necessary for further disease prognosis. Age was an important risk factor that affects the positivity of influenza A, H1N1, and RSV. Different clinical manifestation of H1N1 and RSV will be helpful for early and accurate diagnosis. J. Med. Virol. 89:49-54, 2017. © 2016 Wiley Periodicals, Inc.

The effects of age on clinical characteristics, hospitalization and mortality of patients with influenza‐related illness at a tertiary care centre in Malaysia

“…Our findings overall showed that cough is the most common clinical finding, accounting for approximately 85% of cases whereas fever and nasal congestion were present in >80% and >50% of cases, respectively. These features are consistent with the World Health Organization's (WHO) definition of ILI and previous observations . Symptoms of influenza typically subside within 5‐8 days with 95% of cases in this study reporting a duration of illness of less than a week.…”

Influenza A Virus as a Predisposing Factor for Cryptococcosis

“…IAV is a major cause of epidemics and pandemics in humans, occasioning high morbidity and mortality worldwide (Saxena et al, 2017 ). The IAV infections are widely associated with secondary invasive aspergillosis, even among immunocompetent hosts, including those without classic risk factors (Kwon et al, 2013 ; Alshabani et al, 2015 ; Crum-Cianflone, 2016 ).…”

Evaluation of Seegene Allplex Respiratory Panel 1 kit for the detection of influenza virus and human respiratory syncytial virus

“…Acute respiratory infections (ARI) represent a major threat to public health. Influenza virus (FLUV) and human respiratory syncytial virus (HRSV) respiratory infections are responsible for significant morbidity and mortality in both pediatric and adult population worldwide [1,2]. Seasonal FLUV has been estimated to affect 5-10% of the world's population [3] and by the age of two, practically all children are estimated to have been infected at least once with HRSV [4].…”