Clinical characterization of human bocavirus 1 infection in infants hospitalized in an intensive care unit for severe acute respiratory tract disease

Boggio, Gabriel Amilcar; Moreno, Laura; Salbetti, María Belén Colazo; Villarreal, Verónica; Torres, Elisabeth Fátima; Adamo, María Pilar

doi:10.1016/j.diagmicrobio.2023.116050

Cited by 2 publications

(7 citation statements)

References 34 publications

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“…43 Clinical markers depend on the severity of the respiratory infection and may include symptoms and signs such as fever, rhinorrhoea, cough, wheezing, hypoxaemia, etc. 59 These are generally concomitant with viral RNA detection. 88 The cellular immune response to HBoV1 infection has not been studied in depth, thus data on HBoV-specific T cell immunity are still limited.…”

Section: Immune Responsementioning

confidence: 98%

“…Supportive measures such as hydration and oxygen administration, with or without bronchodilators, are recommended. 59 Cases of HBoV1 bronchiolitis are indistinguishable from those caused by other respiratory viruses. Viral pneumonia in children <2 years old is often interpreted as bacterial aetiology, leading to the administration of antibiotics which have no effect on the course of viral infection.…”

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

“…43,44,50 Similarly, prospective studies with registration of clinical manifestations and quantitative molecular detection consistently indicate that mono-infection and high viral load can associate to severe acute respiratory infection (SARI) in infants <2 years old, even in the absence of additional risk factors or co-morbidities. 49,[54][55][56][57][58][59] Multiple studies provide evidence that infants hospitalised for moderate to severe infection in whom HBoV1 is the sole pathogen detected are frequently diagnosed with bronchiolitis and pneumonia, with common clinical manifestations such as cough, rhinitis, fever, and wheezing. 49,51,[58][59][60][61][62][63][64][65][66] No haematological involvement related to this virus has been described to date.…”

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

“…49,[54][55][56][57][58][59] Multiple studies provide evidence that infants hospitalised for moderate to severe infection in whom HBoV1 is the sole pathogen detected are frequently diagnosed with bronchiolitis and pneumonia, with common clinical manifestations such as cough, rhinitis, fever, and wheezing. 49,51,[58][59][60][61][62][63][64][65][66] No haematological involvement related to this virus has been described to date.…”

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

“…68 Severity parameters such as days of hospitalisation at ICU, days of ventilation, oxygenation index, white blood cell count and C-reactive protein are not significantly different in patients <2 years old with SARI and HBoV1 infection compared to respiratory syncytial virus (RSV). 59 It has been shown also that HBoV1 can cause a similar or even more severe illnesses than metapneumovirus when comparing clinical features of hospitalised children with acute lower respiratory infection (ALRI) such as fever, cough, wheezing, congestion and runny nose, cyanosis, low breath sounds, stridor and crackles, oxygen saturation, tachypnoea, dyspnoea, white blood cell count, C-reactive protein, ICU admission, requirement for oxygen therapy and mechanical ventilation. 69 In this scenario, HBoV1 detection may certainly contribute to the standard testing repertoire for the diagnosis of SARI in hospitalised infants.…”

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

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Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

Colazo Salbetti,

Boggio,

Moreno

et al. 2023

Reviews in Medical Virology

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Human bocaviruses were first described between 2005 and 2010, identified in respiratory and enteric tract samples of children. Screening studies have shown worldwide distribution. Based on phylogenetic analysis, they were classified into four genotypes (HBoV1‐4). From a clinical perspective, human bocavirus 1 (HBoV1) is considered the most relevant, since it can cause upper and lower acute respiratory tract infection, mainly in infants, including common cold, bronchiolitis, and pneumonia, as well as wheezing in susceptible patients. However, the specific processes leading to structural, biochemical, and functional changes resulting in the different clinical presentations have not been elucidated yet. This review surveys the interactions between the virus and target cells that can potentially explain disease‐causing mechanisms. It also summarises the clinical phenotype of cases, stressing the role of HBoV1 as an aetiological agent of lower acute respiratory infection in infants, together with laboratory tests for detection and diagnosis. By exploring the current knowledge on the epidemiology of HBoV1, insights into the complex scenario of paediatric respiratory infections are presented, as well as the potential effects that changes in the circulation can have on the dynamics of respiratory agents, spotlighting the benefits of comprehensively increase insights into incidence, interrelationships with co‐circulating agents and potential control of HBoV1.

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Section: Immune Responsementioning

confidence: 98%

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

Section: Natural History Of Infection Pathophysiology and Clinical Fe...mentioning

confidence: 99%

See 3 more Smart Citations

Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

Colazo Salbetti,

Boggio,

Moreno

et al. 2023

Reviews in Medical Virology

Self Cite

View full text Add to dashboard Cite

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Assessing the change in the epidemiology of seasonal respiratory viruses with the onset of the COVID-19 pandemic

Kara,

Kizil,

İşeri Nepesov

et al. 2024

Journal of General Virology

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Background. Respiratory tract infections are among the most important causes of mortality and morbidity in children worldwide. The COVID-19 pandemic has affected the distribution of seasonal respiratory viruses as in all areas of life. In this study, we have aimed to evaluate the changes in the rates of seasonal respiratory viruses with the onset of the pandemic. Methods. This study included patients who were admitted to the Pediatrics Clinic of Eskisehir Osmangazi University Faculty of Medicine Hospital between December 2018 and February 2022 with respiratory tract infections and in whom pathogens were detected from nasopharyngeal swab samples analysed by multiplex PCR method. Results. A total of 833 respiratory tract pathogens were detected in 684 cases consisting of male (55.3 %), and female (44.7 %), patients with a total mean age of 42 months. Single pathogen was revealed in 550, and multiple pathogens in 134 cases. Intensive care was needed in 14 % of the cases. Most frequently influenza A/B, rhinovirus and respiratory syncytial virus (RSV) were detected during the pre-pandemic period, while rhinovirus, RSV, and adenovirus were observed during the lockdown period. In the post-lockdown period, the incidence rates of rhinovirus, RSV, human bocavirus (HboV) (12 %), influenza virus infections increased, and patients with RSV and bocavirus infections required intensive care hospitalization. Conclusion. It is thought that the COVID-9 pandemic lockdown measures may have an impact on the distribution of seasonal respiratory viruses, especially RSV and influenza. Current, prospective and large case series regarding the mechanism of action and dynamics are needed.

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Clinical characterization of human bocavirus 1 infection in infants hospitalized in an intensive care unit for severe acute respiratory tract disease

Cited by 2 publications

References 34 publications

Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

Assessing the change in the epidemiology of seasonal respiratory viruses with the onset of the COVID-19 pandemic

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