Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome

Smith, Elliot; Tekola, Bezawit D.; Patrie, James T.; Cornella, Scott L.; Caldwell, Stephen H.

doi:10.1016/j.amjmed.2016.07.007

Cited by 14 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, patients with GAVE are known to have higher recurrence of bleeding after endoscopic intervention, and blood loss in these patients may continue for a chronic duration. Literature reports that up to 62% of patients with GAVE may remain transfusion dependent [ 16 ]. Hence, we believe that it is imperative to identify patient demographics and establish risk factors for GAVE hospitalizations to design a robust management plan to reduce morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, a retrospective cohort study by Smith et al on 135 patients revealed a significant correlation of GAVE with liver disease, diabetes mellitus, body mass index (BMI), and vascular disease [ 16 ]. Similarly in our study, we noted increasing proportion of patients with comorbidities such as hypertension, renal failure, cirrhosis, diabetes mellitus, obesity, and peripheral vascular disease in these hospitalizations ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastric Antral Vascular Ectasia: Trends of Hospitalizations, Biodemographic Characteristics, and Outcomes With Watermelon Stomach

et al. 2021

View full text Add to dashboard Cite

Background: Gastric antral vascular ectasia (GAVE) syndrome is a rare but significant cause of acute or chronic gastrointestinal (GI) bleeding, particularly in the elderly. The primary objective of this study was to determine the biodemographic characteristics, adverse outcomes, and the impact of GAVE hospitalizations on the US healthcare system.Methods: This retrospective database cross-sectional study used the National Inpatient Sample (NIS) from 2001 to 2011 to identify all adult hospitalizations with a primary discharge diagnosis of GAVE, with and without hemorrhage, using the International Classification of Diseases, Ninth Revision (ICD-9) codes. Individuals less than 17 years of age were excluded from the study. The outcomes included biodemographic characteristics, comorbidity measures, and inpatient mortality and the burden of the disease on the US healthcare system in terms of healthcare cost and utilization.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gastric Antral Vascular Ectasia: Trends of Hospitalizations, Biodemographic Characteristics, and Outcomes With Watermelon Stomach

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, the prevalence of NASH cirrhosis and the components of metabolic syndrome, such as diabetes, hypertension, and dyslipidemia, were significantly higher in the GAVE group. 3 We conducted a similar retrospective study using a cohort of 941 patients with cirrhosis who underwent EGD for UGIB, ultimately dividing them into patients with GAVE (diagnosed endoscopically, with or without biopsy) and those with variceal bleed. We found that there was a significantly higher prevalence of obesity (measured via body mass index [BMI]), hypertension, diabetes mellitus, and NASH cirrhosis among the GAVE group (Table 1).…”

Section: Gave and Metabolic Syndromementioning

confidence: 99%

“…GAVE is strongly associated with chronic liver disease. In particular, 30% to 64% of individuals with GAVE have cirrhosis 1‐3 …”

mentioning

confidence: 99%

An Unexpected Association: Might GAVE Pave the Way to How the Metabolic Syndrome Behaves

Jariwala

Shoreibah

2021

Clinical Liver Disease

View full text Add to dashboard Cite

Gastric antral vascular ectasia (GAVE) accounts for 4% of nonvariceal upper gastrointestinal bleeds (UGIBs), manifesting with iron deficiency anemia requiring recurrent blood transfusions. Patients typically present with intermittent melena and, occasionally, hematemesis. However, some present with anemia without any overt gastrointestinal blood losses. GAVE is strongly associated with chronic liver disease. In particular, 30% to 64% of individuals with GAVE have cirrhosis. [1][2][3] PaTHOGenesis OF Gave in PaTienTs wiTH CirrHOsisThe pathogenesis of GAVE disease is not well understood; the disease has been linked to mechanical stress, portal hypertension, liver dysfunction, and metabolic syndrome. Mechanical stress was once considered to be the primary reason for the formation of antral GAVE. Several studies have outlined abnormal antral motility studies in patients with GAVE and cirrhosis. 4 According to this theory, the peristalsis of gastric mucosa through the pylorus causes fibromuscular hyperplasia, leading to the formation of ectatic vessels as a by-product. However, this theory falls short in that it does not explain the formation of ectatic vessels elsewhere in the gastrointestinal tract, an occurrence that has been described in the literature. 4 Given the high association between GAVE and cirrhosis, portal hypertension was thought to be a possible cause of GAVE, similar to portal hypertensive gastropathy (PHG). 5 However, one study documented that transjugular intrahepatic portosystemic shunt (TIPS) was not associated with

show abstract

“…We read with great interest the work of Smith et al, 1 which examined the association between gastric antral vascular ectasia (GAVE) and metabolic syndrome. The study offers an intriguing perspective on GAVE as a potential manifestation of metabolic syndrome.…”

mentioning

confidence: 99%

Gastric Antral Vascular Ectasia and Metabolic Syndrome: Is There a Case for an Association?

Shoreibah

Peter

2017

The American Journal of Medicine

View full text Add to dashboard Cite

Clinical Characterization of Gastric Antral Vascular Ectasia: A Potential Manifestation of the Metabolic Syndrome

Cited by 14 publications

References 42 publications

Gastric Antral Vascular Ectasia: Trends of Hospitalizations, Biodemographic Characteristics, and Outcomes With Watermelon Stomach

Gastric Antral Vascular Ectasia: Trends of Hospitalizations, Biodemographic Characteristics, and Outcomes With Watermelon Stomach

An Unexpected Association: Might GAVE Pave the Way to How the Metabolic Syndrome Behaves

Gastric Antral Vascular Ectasia and Metabolic Syndrome: Is There a Case for an Association?

Contact Info

Product

Resources

About