Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

Ughi, Giovanni Jacopo; Wang, Hao; Gerbaud, Édouard; Gardecki, Joseph A.; Fard, Ali; Hamidi, Ehsan; Vacas-Jacques, Paulino; Rosenberg, Mireille; Jaffer, Farouc A.; Tearney, Guillermo J.

doi:10.1016/j.jcmg.2015.11.020

Cited by 146 publications

(107 citation statements)

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“…Combining detection of fluorescence with OCT in a multimodal intravascular catheter (Fig. 16) has also been demonstrated, complementing the structural OCT signal with true molecular information [120][121][122][123]. These catheters employ a dual clad fiber to collect fluorescence through the inner cladding while operating OCT through the single mode core of the fiber.…”

Section: Discussionmentioning

confidence: 99%

“…These catheters employ a dual clad fiber to collect fluorescence through the inner cladding while operating OCT through the single mode core of the fiber. After initial demonstration in rabbit aorta [120], the autofluorescence of fibroatheromas has been investigated in human patients [122], and the use of indocyanine green (ICG) as a contrast agent to label regions of inflammation and compromised endothelial function has been explored in carotid samples obtained from patients that received an intravenous injection of ICG before endarterectomy [123], and in a swine model of atherosclerosis [121] (Figs. 16 and 17).…”

Section: Discussionmentioning

confidence: 99%

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Intravascular optical coherence tomography [Invited]

Bouma

Villiger

Otsuka

et al. 2017

Biomed. Opt. Express

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Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, highperformance commercial imaging systems, the key studies that laid the groundwork for image interpretation, and the clinical research that traces intravascular optical coherence tomography (OCT) from early human pilot studies to current clinical trials. Fujimoto, "Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology," Circulation 93(6), 1206-1213 (1996). 4. D. Mozaffarian, E. Benjamin, A. Go, D. K. Arnett, M. J. Blaha, M. Cushman, S. R. Das, M. Sarah de Ferranti, J.-P. Després, and H. J. Fullerton, AHA Statistical Update: Heart Disease and Stroke Statistics (AHA, 2015). 5. E. Falk, P. K. Shah, and V. Fuster, "Coronary plaque disruption," Circulation 92(3), 657-671 (1995). 6. R. T. Lee and P. Libby, "The unstable atheroma," Arterioscler. Thromb. Vasc. Biol. 17(10), 1859-1867 (1997). 7. G. K. Sukhova, U. Schönbeck, E. Rabkin, F. J. Schoen, A. R. Poole, R. C. Billinghurst, and P. Libby, "Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques," Circulation 99(19), 2503-2509 (1999). 8. R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 20(5), 1262-1275 (2000). 9. J. A. Condado, R. Waksman, O. Gurdiel, R. Espinosa, J. Gonzalez, B. Burger, G. Villoria, H. Acquatella, I. R.Crocker, K. B. Seung, and S. F. Liprie, "Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans," Circulation 96(3), 727-732 (1997). 10. P. S. Teirstein, V. Massullo, S. Jani, J. J. Popma, G. S. Mintz, R. J. Russo, R. A. Schatz, E. M. Guarneri, S. Steuterman, N. B. Morris, M. B. Leon, and P. Tripuraneni, "Catheter-based radiotherapy to inhibit restenosis after coronary stenting," N. Engl. J. Med. 336(24), 1697-1703 (1997). 11. P. G. Yock and P. J. Fitzgerald, "Intravascular ultrasound: state of the art and future directions," Am. J. Cardiol. 81(7 7A), 27E-32E (1998). 12. P. G. Yock, P. J. Fitzgerald, D. T. Linker, and B. A. Angelsen, "Intravascular ultrasound guidance for catheterbased coronary interventions," J. Am. Coll. Cardiol. 17(6), 39-45 (1991). 13. F. M. Baer, P. Theissen, J. Crnac, M. Schmidt, M. Jochims, and H. Schicha, "MRI assessment of coronary artery disease," Rays 24(1), 46-59 (1999). 14. G. G. Zimmermann-Paul, H. H. Quick, P. Vogt, G. K. von Schulthess, D. Kling, and J. F. Debatin, "Highresolution intravascular magnetic res...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intravascular optical coherence tomography [Invited]

Bouma

Villiger

Otsuka

et al. 2017

Biomed. Opt. Express

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“…To further improve OCT's capability to differentiate types of atherosclerotic lesions, first in human results were published with a dual-modality catheter that can simultaneously collect OCT and near-infrared autofluorescence (NIRAF) from the same location in the tissue [111]. A special rotary-junction enabled volumetric imaging with both modalities showing focal distribution of NIRAF signal corresponding to plaques with a high-risk morphological phenotype.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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“…The 3D navigation menu supports functions to move throughout the 3D rendering and object segmentation to turn on and off the displayed 3D objects including tissue, lumen, stent, wires, and side branches. (16,17).…”

Section: Limitationsmentioning

confidence: 99%

Current Clinical Applications of Intravascular Optical Coherence Tomography in Coronary Artery Disease

Kubo

Matsuo

Ino

et al. 2018

Annals of Nuclear Cardiology

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Optical coherence tomography (OCT) has emerged as a high-resolution (10-20μm), light-based, intravascular imaging technique capable of investigating detailed coronary plaque morphology. OCT is highly sensitive and specific for characterizing fibrous, fibrocalcific, and lipid-rich plaque. OCT is capable of discriminating 3 types of unstable plaque morphologies underlying coronary thrombosis such as plaque rupture, erosion, and calcified nodules. The high resolution of OCT has a potential to identify important features of vulnerable plaques such as thin-cap (<65μm thick) fibroatheroma, macrophages, vasa vasorums, cholesterol crystals, and micro- OCT technologyOCT uses near infrared light, at a wavelength of 1,250-1, 350 nm, to create images. The resolution of OCT is 10-20μm, which is approximately 10 times higher than that of IVUS.The imaging depth of OCT is 1.0-2.0 mm (depending on tissue type), which is approximately one-tenth of that of IVUS. The scan diameter of OCT is up to 10 mm. Imaging catheter of OCT has 2.5-2.8 Fr crossing profile. The imaging catheter is Annals of Nuclear Cardiology

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Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging

Cited by 146 publications

References 23 publications

Intravascular optical coherence tomography [Invited]

Intravascular optical coherence tomography [Invited]

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Current Clinical Applications of Intravascular Optical Coherence Tomography in Coronary Artery Disease

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