Clinical characteristics, respiratory management, and determinants of oxygenation in COVID-19 ARDS: A prospective cohort study

Bakker, Jan; Loudet, Cecilia; Dubin, Arnaldo; Edul, Vanina Siham Kanoore; Plotnikow, Gustavo; Andrian, Macarena; Romero, Ignacio; Sagardía, Judith; Bezzi, Marco; Mandich, Verónica; Groer, Carla; Torres, Sandra; Orlandi, Cristina; Birri, Paolo Nahuel Rubatto; Valenti, María Florencia; Cunto, Eleonora; Saenz, María G; Tiribelli, Norberto; Aphalo, Vanina; Bettini, Lisandro Roberto; Ríos, Fernando; Reina, Rosa

doi:10.1016/j.jcrc.2022.154021

Cited by 20 publications

(23 citation statements)

References 40 publications

(70 reference statements)

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“… 3 Obesity, elderly age, and underlying renal and cardiac disease are associated more severe degrees of hypoxemia and severe COVID-19 disease. 4 However, early in the pandemic, it was observed that the degree of hypoxemia caused by COVID-19 lung disease was poorly associated with both the severity of parenchymal involvement on computed tomography (CT) and the presence of respiratory symptoms, especially dyspnea. Additionally, early reports of intubated, critically-ill patients with COVID-19 suggested a subgroup of patients in which impaired gas exchange was associated with preserved compliance, a pattern purportedly unique to COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“… 59 Ventilatory ratios have been variably associated with degree of hypoxemia in COVID-19 lung disease and this association can change over the course of disease. 4 , 57 , 60 , 61 …”

Section: Introductionmentioning

confidence: 99%

“… 57 , 66 In one study, compliance and oxygenation were not initially correlated on day 1 of intubation, but there was a strong positive correlation by day 7, 61 suggesting progression of parenchymal injury and non-aerated lung regions; however other longitudinal studies have not reproduced this finding. 4 Recruitability, or the ability of nonaerated or poorly aerated lung parenchyma to be reopened with additional positive end-expiratory pressure (PEEP), is likewise variably associated with the severity of hypoxemia before recruitment. 49 , 61 Surprisingly, even with significant inter-individual variability, recruitability does not appear to predict oxygenation response to increases in PEEP.…”

Section: Introductionmentioning

confidence: 99%

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Pathophysiology of Hypoxemia in COVID-19 Lung Disease

Swenson

Hardin

2023

Clinics in Chest Medicine

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Section: Introductionmentioning

confidence: 99%

“… 59 Ventilatory ratios have been variably associated with degree of hypoxemia in COVID-19 lung disease and this association can change over the course of disease. 4 , 57 , 60 , 61 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathophysiology of Hypoxemia in COVID-19 Lung Disease

Swenson

Hardin

2023

Clinics in Chest Medicine

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“…However, although mechanical support is very important for patients with COVID-19 infection, it is not feasible to advocate a single guideline for this condition ( 55 ). Rather, the approach needs to be tailored to every individual patient to prevent serious complications ( 55 , 56 ).…”

Section: Sars-cov-2 Damages the Lungsmentioning

confidence: 99%

Biological effects of COVID-19 on lung cancer: Can we drive our decisions

et al. 2022

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COVID-19 infection caused by SARS-CoV-2 is considered catastrophic because it affects multiple organs, particularly those of the respiratory tract. Although the consequences of this infection are not fully clear, it causes damage to the lungs, the cardiovascular and nervous systems, and other organs, subsequently inducing organ failure. In particular, the effects of SARS-CoV-2-induced inflammation on cancer cells and the tumor microenvironment need to be investigated. COVID-19 may alter the tumor microenvironment, promoting cancer cell proliferation and dormant cancer cell (DCC) reawakening. DCCs reawakened upon infection with SARS-CoV-2 can populate the premetastatic niche in the lungs and other organs, leading to tumor dissemination. DCC reawakening and consequent neutrophil and monocyte/macrophage activation with an uncontrolled cascade of pro-inflammatory cytokines are the most severe clinical effects of COVID-19. Moreover, neutrophil extracellular traps have been demonstrated to activate the dissemination of premetastatic cells into the lungs. Further studies are warranted to better define the roles of COVID-19 in inflammation as well as in tumor development and tumor cell metastasis; the results of these studies will aid in the development of further targeted therapies, both for cancer prevention and the treatment of patients with COVID-19.

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“…COVID-19 is primarily a respiratory disease, with major symptoms including shortness of breath, fever, cough, and loss of taste and smell. These initial symptoms can progress into acute respiratory distress syndrome (ARDS), which is a serious complication with high mortality rates, often requiring mechanical ventilation [ 6 ]. However, COVID-19 induces serious effects across multiple organs, including the brain [ 7 , 8 ], the gastrointestinal tract [ 9 ], the urinary system, and the cardiovascular system [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem Cells

2022

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Although SARS-CoV-2, the causative virus of the global COVID-19 pandemic, primarily affects the respiratory tract, it is now recognized to have broad multi-organ tropism and systemic effects. Early reports indicated that SARS-CoV-2 infection could lead to cardiac damage, suggesting the virus may directly impact the heart. Cardiac cell types derived from human pluripotent stem cells (hPSCs) enable mechanistic interrogation of SARS-CoV-2 infection in human cardiac tissue. Purpose of Review To review the studies published since the emergence of the COVID-19 pandemic which utilize hPSCs and their cardiovascular derivative cell types to interrogate the tropism and effects of SARS-CoV-2 infection in the heart, as well as explore potential therapies. Recent Findings Recent studies reveal that SARS-CoV-2 is capable of infecting and replicating within hPSC-derived cardiomyocytes and sinoatrial nodal cells, but not as extensively in their non-parenchymal counterparts. Additionally, they show striking viral effects on cardiomyocyte structure, transcriptional activity, and survival, along with potential mechanisms and therapeutic targets. Summary Cardiac models derived from hPSCs are a viable platform to study the impact of SARS-CoV-2 on cardiac tissue and may lead to novel mechanistic insight as well as therapeutic interventions.

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Clinical characteristics, respiratory management, and determinants of oxygenation in COVID-19 ARDS: A prospective cohort study

Cited by 20 publications

References 40 publications

Pathophysiology of Hypoxemia in COVID-19 Lung Disease

Pathophysiology of Hypoxemia in COVID-19 Lung Disease

Biological effects of COVID-19 on lung cancer: Can we drive our decisions

Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem Cells

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