Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer‐related cognitive impairment in adults

Wefel, Jeffrey S.; Kesler, Shelli R.; Noll, Kyle R.; Schagen, Sanne B.

doi:10.3322/caac.21258

Cited by 416 publications

(493 citation statements)

References 235 publications

(518 reference statements)

Supporting

Mentioning

437

Contrasting

Unclassified

Order By: Relevance

“…However, besides well known immediate side effects, such as nausea, chemotherapy has also been associated with long-term negative consequences, such as cardiovascular disease [2] and the potential neurotoxicity of chemotherapy [3,4] through possible disturbance of various mechanisms including apoptosis and suppressed neurogenesis [5].…”

mentioning

confidence: 99%

“…We will also examine a 'dose-response relationship' by distinguishing patients who were treated with standard dose chemotherapy from those for whom standard dose chemotherapy was unsuccessful and who were therefore treated with supplementary high dose chemotherapy. In addition, because not all patients may be equally affected [4], we will also examine whether a subgroup of patients have deviant cognitive function. If so, we will explore possible neuro-epidemiological differences such as protective 'cognitive reserve' [3,4,16] and younger age [10] between patients with deviant cognitive function and patients with normal cognitive function.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Neurocognitive function of lymphoma patients after treatment with chemotherapy

2016

Self Cite

View full text Add to dashboard Cite

Background: Chemotherapy has been shown to cause brain changes and to compromise cognitive function in cancer survivors. Knowledge about this matter is of vital importance for good clinical practice and insights into neurological aging. However, most studies have been conducted among breast cancer patients. Less is known about the effects of chemotherapy on the cognitive function of lymphoma patients. Material and method: We studied patients with non-Hodgkin or Hodgkin lymphoma who had been treated with standard dose chemotherapy or with supplementary high dose chemotherapy when standard dose chemotherapy had been unsuccessful. Age-and sex-matched relatives and friends were invited to participate as control participants. All participants underwent a cognitive examination with a battery of validated neuropsychological tests. Results: Matching of patients with control participants was found to be successful. Regression analysis did not reveal worse cognitive functioning of patients (N ¼ 106) compared to matched controls (N ¼ 53) on the overall group level (All Bonferroni-Holm corrected p-values >0.05). However, a subgroup of 16% of patients had deviant performance according to a chance-corrected criterion based on Ingraham and Aiken's probability curves, i.e. 1.5 standard deviations below the norm on three of 14 tests. Exploratory analyses showed that this subgroup of patients was lower educated and had lower estimated premorbid intelligence. Conclusion: Chemotherapy may compromise the function of the brain in a subgroup of lymphoma patients. We hypothesize protection of the brain by 'cognitive or brain reserve' as a possible explanation.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Neurocognitive function of lymphoma patients after treatment with chemotherapy

2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…These adverse effects were noted in the patient's medical record and are not a result of the aging process. The changes were so pronounced that (based on literature review) cancer-related cognitive dysfunction may be suspected (Hermelink et al, 2017;Isenberg-Grzeda & Ellis, 2017;Johns et al, 2016;Wefel et al, 2015).…”

Section: Resultsmentioning

confidence: 98%

“…The level of dysfunction, however, is a very individual feature (Hermelink et al, 2017;Wefel et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Initial Study on Cancer-Related Cognitive Dysfunction With the Implementation of QEEG

Zolubak

Kawala-Janik

Podpora

et al. 2017

Studies in Logic, Grammar and Rhetoric

View full text Add to dashboard Cite

Abstract. Chemotherapy is one of the most common treatments used in cancer therapy despite its serious side effects, which remain a huge concern. To the most common side effects (apart from weight and hair loss) include memory and concentration problems as well as changes in taste. This paper presents a very preliminary study (with only one elderly female subject participating) focusing on cognitive dysfunction after chemotherapy in breast cancer. This phenomenon, called Cancer-Related Cognitive Dysfunction (CRCD), is a frequent occurrence. The obtained results prove the impact of chemotherapy on the participant's ability to concentrate. The QEEG method and digital data analysis were used as the measurement methods.

show abstract

“…Longitudinal studies of men with various cancers have identified that 16-48% had lower-than-normal cognitive performance prior to cancer treatment (Janelsins et al 2014, Wefel et al 2015. As cognitive function is rarely measured prior to ADT administration, many studies are observational, and few studies have provided a measure of estimated cognitive reserve.…”

Section: The Effects Of Androgen Deprivation On Cognitive Functionmentioning

confidence: 99%

Cognitive decline in prostate cancer patients undergoing ADT: a potential role for exercise training

Mundell¹,

Daly²,

Macpherson³

2017

Endocrine-Related Cancer

View full text Add to dashboard Cite

Androgen deprivation therapy (ADT) is an effective and widely prescribed treatment for prostate cancer (PCa), but it is associated with multiple treatment-induced adverse effects that impact on various musculoskeletal and cardiometabolic health outcomes. Emerging research has shown that ADT is also associated with cognitive impairment, which has been linked to a loss of independence, increased falls and fracture risk and greater use of medical services. The aim of this review is to outline the evidence related to the effect of ADT use on cognitive function, and propose a role for exercise training as part of usual care to prevent and/or manage cognitive impairments for PCa survivors on ADT. The following results have been obtained from this study. ADT has been shown to adversely affect specific cognitive domains, particularly verbal memory, visuomotor function, attention and executive function. However, current clinical guidelines do not recommend routine assessment of cognitive function in these men. No studies have examined whether exercise training can preserve or improve cognitive function in these men, but in healthy adults', multimodal exercise training incorporating aerobic training, progressive resistance training (PRT) and challenging motor control exercises have the potential to attenuate cognitive decline. In conclusion, as treatment with ADT for men with PCa has been associated with a decline in cognition, it is recommended that cognitive function be routinely monitored in these men and that regular exercise training be prescribed to preserve (or improve) cognitive function. Assessment of cognition and individualised exercise training should be considered in the usual treatment plan of PCa patients receiving ADT.

show abstract

Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer‐related cognitive impairment in adults

Cited by 416 publications

References 235 publications

Neurocognitive function of lymphoma patients after treatment with chemotherapy

Neurocognitive function of lymphoma patients after treatment with chemotherapy

Initial Study on Cancer-Related Cognitive Dysfunction With the Implementation of QEEG

Cognitive decline in prostate cancer patients undergoing ADT: a potential role for exercise training

Contact Info

Product

Resources

About