Clinical characteristics of women with familial pelvic floor disorders

Norton, Peggy; Allen‐Brady, Kristina; Wu, Jennifer M.; Egger, Marlene J.; Cannon‐Albright, Lisa A.

doi:10.1007/s00192-014-2513-8

Cited by 6 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Эпидемиологические исследования тазовых расстройств показывают, что некоторые женщины могут быть фенотипически или генотипически предрасположены к развитию ПТО. Например, в литературе имеются данные о различиях в распространенности пролапса среди разных этнических групп, а также о семейных случаях ПТО [21,22]. Считается, что одним из возможных факторов риска развития ПТО является гипермобильность суставов.…”

Section: обсуждение основного результата исследованияunclassified

“…По данным литературы, причинами высокой заболеваемости ПТО могут быть социально-демографические факторы, образ жизни женщин, а также внутрипопуляционная генетическая изменчивость, что приводит к индивидуальным изменениям структуры и функции ко мпонентов тазового дна [21]. Теория о роли генетической изменчивости и наследственности в развитии ПТО также была представлена в ряде эпидемиологических исследований.…”

Section: обсуждение основного результата исследованияunclassified

See 1 more Smart Citation

Nat2 Gene Polymorphism as a Predictor of Failure for Surgical Treatment of Pelvic Organ Prolapse: Results of a Prospective Cohort Clinical Study

Dubinskaya

Dubinskaya²,

Kolesnikova

et al. 2017

Annals RAMS

View full text Add to dashboard Cite

Background: Pelvic organ prolapse (POP) is the most frequent disease component in the structure of gynecological pathology (from 28 to 38.9%) and its incidence is increasing. Most of the research studies were initiated to develop various kinds of operative treatment for common prolapse cases (POP-Q III−IV); however, a large number of surgical interventions associated with a high percentage of complications and a high rate of relapses confirm the difficulty for problem-solving. In this regard, there is a need to expand ideas about the pathogenesis of the disease and develop approaches to the prediction of recurrence surgical treatment, choosing the correct and timely treatment strategy. Currently, great importance is given to the study of genetic control of connective tissue metabolism. The evidence demonstrated that polymorphism of NAT2 gene results in genetically determined disorders of connective tissue catabolism which increases the possibility of disease development approximately in 2 times. Point mutations in NAT2 lead to the so-called slow-acetylation which determines the predominance of the decay rate of collagen over its synthesis.Aim: Analyze the significance of NAT2 polymorphism as a predictor for failure of surgical treatment of pelvic organ prolapse.Materials and methods: The prospective cohort clinical trial enrolled 140 women of the reproductive age (from 28 to 42 y.o.) with symptomatic prolapse (POP-Q Stage II−III) who were examined and received treatment in the period from 2008 to 2014. All patients underwent surgical treatment of POP. The treatment included colpoperineorrhaphy with levatorplasty. In 12.9% of patients who had stress urinary incontinence — in combination with a loop urethropexies transobturatory access (Transobturator Vaginal Tape, TVT-O). Long-term results of treatment effectiveness were assessed in 3−5 years. Results: The findings revealed that the incidence rate of point mutations of NAT2 gene was 2-fold higher in patients with POP included in the ineffective treatment group (61.8%) if compared to the rate registered in the effective treatment group (30.6%).Conclusions: The obtained data indicate that the presence of point mutations in NAT2 gene is a poor prognostic factor for general types of genital prolapse and a predictor for failure of surgical treatment.

show abstract

Section: обсуждение основного результата исследованияunclassified

Nat2 Gene Polymorphism as a Predictor of Failure for Surgical Treatment of Pelvic Organ Prolapse: Results of a Prospective Cohort Clinical Study

Dubinskaya

Dubinskaya²,

Kolesnikova

et al. 2017

Annals RAMS

View full text Add to dashboard Cite

show abstract

“…The physical and hormonal changes in pregnancy, changes in the urethrovesical angle, anatomical defects during delivery, the dynamic force of the pelvic floor muscles and connective tissue and genetic factors may be involved in this process. 2,3 Many women experience their first symptoms of incontinence during pregnancy. These women along with those with UI prior to pregnancy appear to be at increased risk for postpartum UI.…”

Section: Introductionmentioning

confidence: 99%

Urine Incontinence Before and After Delivery in Primipara

Shrestha¹,

Regmi

Guddy

2020

J. KIST Med. Coll.

View full text Add to dashboard Cite

Introduction: Urinary incontinence is a common condition in pregnancy and postpartum period. It causes discomfort, embarrassment, loss of confidence and self esteem. This study aimed to determine the occurrence of urinary incontinence in pregnant attending antenatal clinic in a tertiary hospital. Methods: A descriptive observational study was conducted to find out occurrence of urinary incontinence in primiparous attending department of obstetrics and gynecology from August 2014 to August 2015 at B.P. Koirala Institute of Health Sciences. Results: The total of 100 primigravida were enrolled in the study. Out of which six had urinary incontinence with mean age of 23 years. Most of them were in the period of gestation group 38–40 weeks. 22% of total were obese with mean BMI of 26.69 kg/m2. Seventy nine patients had vaginal delivery, four had vacuum assisted vaginal delivery and 17 had cesarean section. Age and Body Mass Index (BMI) was not found to be associated with urinary incontinence. Oxford grading for assessment of perineal muscle after delivery showed decline in pelvic muscle tone which was significantly associated with urinary incontinence. However, the mode of delivery, and birth weight of baby was not found to be significant. Conclusion: The study finding suggested that pregnancy acts a risk factor for development of UI although no preference could be drawn regarding the mode of delivery. Our study also concluded antepartum UI as a risk factor for postpartum UI.

show abstract

“…Historically, the surgical options for SUI and POP relied on directly repairing the patient’s own native tissues by using sutures 2 or repositioning strips of the patient’s fascia to provide support 3 . The Burch colposuspension uses a retropubic approach to resuspend the bladder neck back to the correct anatomical location by using sutures.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of SUI and POP typically increases with age, and the peak incidence is in post-menopausal, multiparous women. Several other factors (related to both lifestyle and genetics), including obesity 3 and smoking and connective tissue disorders 4 , may contribute to pelvic floor instability. As such, the recurrence and reoperation rates for prolapse with native tissue repair alone were high (failure rate of 17 to 20% at 10 years 5 ) as the patient’s tissues often are not of sufficient quality or strength to be repaired.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in pelvic floor repair

2019

View full text Add to dashboard Cite

Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are conditions which result in significant physical, mental and social consequences for women worldwide. The high rates of recurrence reported with primary repair for POP led to the use of synthetic mesh to augment repairs in both primary and secondary cases following failed previous POP repair. The widely reported, unacceptably high rates of complications associated with the use of synthetic, transvaginal mesh in pelvic floor repair have severely limited the treatment options that surgeons can offer. This article summarises the recent advances in pelvic floor repair, such as improved quantification and modelling of the biomechanics of the pelvic floor and the developing technology within the field of tissue engineering for treatment of SUI/POP, including biomaterials and cell-based therapies. Finally, we will discuss the issues surrounding the commercial introduction of synthetic mesh for use within the pelvic floor and what lessons can be learned for the future as well as the current guidance surrounding treatment for SUI/POP.

show abstract

Clinical characteristics of women with familial pelvic floor disorders

Abstract: Familial cases of POP, SUI, and OAB are more likely to have more than one pelvic floor defect. It is likely that underlying genetic factors contribute to more than one pelvic floor defect.

Cited by 6 publications

References 25 publications

Nat2 Gene Polymorphism as a Predictor of Failure for Surgical Treatment of Pelvic Organ Prolapse: Results of a Prospective Cohort Clinical Study

Nat2 Gene Polymorphism as a Predictor of Failure for Surgical Treatment of Pelvic Organ Prolapse: Results of a Prospective Cohort Clinical Study

Urine Incontinence Before and After Delivery in Primipara

Recent advances in pelvic floor repair

Contact Info

Product

Resources

About