Clinical Characteristics of Tracheobronchopathia Osteochondroplastica

Luo, Tao; Zhou, Hui; Meng, Jian

doi:10.4187/respcare.05867

Cited by 15 publications

(23 citation statements)

References 18 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the median age for diagnosis of TPO was 63.0 years, which was similar to the results from other studies (19,20). According to a systematic review that analysed a total of 151 patients, the mean age of TPO patients was 55.8 years (6,7,17,18). Compared to our results (male, 65%), two previous studies reported a higher prevalence of female TPO patients [73% (21) and 66% ( 19) respectively].…”

Section: Discussioncontrasting

confidence: 83%

“…However, the abovementioned studies revealed that the female predominance was a result of the inclusion criteria. In systematic review (6,7,17,18), 80/151 (53.0%) patients had cough and 44/151 (29.1%) patients had haemoptysis. Our study showed that chronic cough was the most common symptom, with a lower proportion of patients with haemoptysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical course of tracheobronchopathia osteochondroplastica

Cho¹,

Jeong²,

Kim³

2020

J Thorac Dis

View full text Add to dashboard Cite

Background: Tracheobronchopathia osteochondroplastica (TPO) is characterized by the presence of diffuse cartilaginous or bony submucosal nodules that lead to airway lumen narrowing. So far, there was no study in South Korea analysing a large number of TPO patients. We aimed to elucidate its treatment strategy and clinical course by analysing the characteristics of TPO patients. Methods: In this retrospective study, we reviewed the clinical data of 40 patients diagnosed with TPO by bronchoscopy between October 1997 and April 2019 at a single referral hospital. Results: Of the 40 patients, 26 (65.0%) were male and the median age was 63.0 years. The most common symptom was cough (n=12, 30%). Pulmonary function test (PFT) revealed an obstructive pattern in 10 (25.7%) patients. Chest computed tomography (CT) scan showed 23 (62.6%) patients with diffuse narrowing and calcified nodules. In bronchoscopy, the entire trachea was found to be involved in 30 (75.0%) patients and airway narrowing was identified in 6 (15.0%) patients. Endobronchial biopsies were obtained from 15 patients and the most common findings included typical cartilaginous and bony tissues (n=14, 93.3%). Since most patients were asymptomatic or had mild symptoms, they did not undergo any specific treatment. Of the 19 symptomatic patients, 2 (5.0%) patients received laser therapy for treating tracheal stenosis. Conclusions: TPO is a slowly progressing disease and is well managed with conservative therapies.Although TPO shows a distinctive pattern by bronchoscopy, it follows a benign clinical course.

show abstract

Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Clinical course of tracheobronchopathia osteochondroplastica

Cho¹,

Jeong²,

Kim³

2020

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…At present, the etiology and pathogenesis of TO have not been fully understood. Coexistence of TO with sarcoidosis, pulmonary adenocarcinoma, breast cancer, esophageal cancer, IgA deficiency and tuberculosis had been reported (7)(8)(9)(10). In the current study, we described two TO patients concomitant with lung adenocarcinoma and thyroid gland cancer, respectively.…”

Section: Discussionmentioning

confidence: 52%

Multi-nodule of large airway: tracheobronchopathia osteochondroplastica

Li¹,

Jin²,

Nan³

et al. 2021

Ann Palliat Med

View full text Add to dashboard Cite

Background: Tracheobronchopathia osteochondroplastica (TO) is a benign rare disease characterized by multiple tracheobronchial nodules, which has not been clearly illuminated and there are no standard guidelines for TO management. The aim of this study was to clarify the clinical features and treatment outcomes of TO and provide basis for clinical diagnosis and treatment.Methods: A total of 32,215 patients taken bronchoscopy were retrospectively reviewed to select patients diagnosed with TO. Clinical characteristics, bronchoscopic manifestations, CT images, histopathological features, treatments and clinical course were investigated.Results: 13 males and 6 females were identified as TO. The average age was 47.42±12.12 years. The incidence rate of TO in our study by bronchoscopy was 0.06%. The most frequent manifestation was chronic cough. Based on bronchoscopic manifestations, patients were categorized as three groups: the largest proportion was group of Stage II (10/19), followed by stage III (5/19) and stage I (4/19). The positive rate of CT in stage I, stage II and stage III was 0%, 50%, 100%, respectively. Histopathological analysis presented inflammatory exudation, squamous metaplasia, submucosal cartilaginous and osseous deposition.Bronchoscopic intervention and inhaled corticosteroids were administered to subjects in stage II and III, which improved their life qualities to some degree.Conclusions: Not only multi-disciplinary cooperation of clinical, endoscopic and histological assessment, but also awareness are crucial to TO diagnosis, especially in early stage of TO, which was difficult to identify.The stage of TO based on bronchoscopic visualization might be applied to guide the choice of clinical treatment strategy.

show abstract

“…29,30 A study made from a large Chinese cohort described 3 stages of the disease based on the severity of presentation on bronchoscopy findings: stage I (plaque-like infiltrations of soft whitish lesions throughout the mucosa, with mucosal hyperemia, and edema), stage II (diffuse cartilaginous nodules protruding to the lumen giving a "cobblestone" appearance), and stage III (deformed and stenotic airway that may cause airflow obstruction; Figure 5). 31 These bronchoscopy stages can be easily correlated with the imaging findings on chest CT; one of our patient was classified as stage I because lesions found were around 1 mm and scattered throughout the airway (Figure 3). Similarly to findings on chest CT: 1 soft tissue nodule (Figure 2).…”

Section: Discussionmentioning

confidence: 83%

Tracheobronchopathia Osteochondroplastica—Clinical, Radiological, and Endoscopic Correlation: Case Series and Literature Review

García

Sangiovanni

Zúñiga-Restrepo

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

View full text Add to dashboard Cite

Tracheobronchopathia osteochondroplastica (TO) is a rare idiopathic and benign disease that is often underdiagnosed. TO is characterized by multiple submucosal cartilaginous and osseous tracheobronchial nodules that spare the posterior wall. It usually affects the elderly, developing when the person is around 60 years old without gender preference and has a reported incidence of 0.11%. TO can be symptomatic and should be considered in patients with chronic cough, dyspnea, and recurrent pulmonary infections. Diagnosis is usually incidental by computed tomography or bronchoscopy, the latter being the gold standard diagnostic test for TO. Many thoracic imagers are not well acquainted with TO; thus, these patients are often underdiagnosed or misdiagnosed. We came across 5 patients in our institution who were incidentally diagnosed with TO, inspiring us to review the available literature on this disease. A total of 33 patients diagnosed with TO between 2009 and 2019 were identified by our retrospective review. Clinical and imaging data were collected on these patients. We also included the clinical, radiological, and endoscopic data of our 5 cases. TO should be considered in patients with chronic cough, dyspnea, and recurrent pulmonary infections. Our experience is that both computed tomography and bronchoscopy can be used to make a reliable diagnosis. It is crucial for physicians, especially radiologists and pulmonologists, to be aware of the existence of TO in order to ensure proper diagnosis.

show abstract

Clinical Characteristics of Tracheobronchopathia Osteochondroplastica

Cited by 15 publications

References 18 publications

Clinical course of tracheobronchopathia osteochondroplastica

Clinical course of tracheobronchopathia osteochondroplastica

Multi-nodule of large airway: tracheobronchopathia osteochondroplastica

Tracheobronchopathia Osteochondroplastica—Clinical, Radiological, and Endoscopic Correlation: Case Series and Literature Review

Contact Info

Product

Resources

About