Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases

Abstract

Background Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient’s risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53. Methods This retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described. Results 82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3–34 months. Conclusions The lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low.

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

“…To be noted, HPV53 ranked second in the present study, which was similar to the report in Xi'an [18]. However, the pathogenicity of single HPV53 infection was low [45]. Besides HR-HPV, the present study also investigated the prevalence distribution of LR-HPV.…”

Prevalence of human papillomavirus genotypes and related cervical morphological results in southern Hunan Province of China, 2018–2020: Baseline measures at a tertiary institution prior to mass human papillomavirus vaccination

“…As the second most carcinogenic genotype in the world, HPV18 ranks only fourth in some Chinese areas or is not even in the top five in other provinces ( Li et al, 2016 ; Zhang et al, 2018 ). Moreover, HPV53 is the fourth or fifth most prevalent genotype in most areas of China ( Sun et al, 2017 ; Chen et al, 2019 , 2021 ; Jiang et al, 2019 ; Wang et al, 2019 , 2022 ; Zhang et al, 2019 , 2020 ; Li et al, 2020 ; Luo et al, 2020 ), and is the most prevalent genotype among healthy women in other Asian countries ( Ouh et al, 2018 ). Our study also demonstrated that HPV81 was the most common low-risk type, with the same overwhelming advantage in other Chinese provinces ( Zhao et al, 2018 ; Chen et al, 2019 ; Zhang et al, 2019 ; Luo et al, 2020 ; Yan et al, 2021 ).…”

Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications

“…Oncogenic strains include the following: 16,18,31,33,35,39,45,51,52,56,58,59 and 66 [31]. HPV-53 is also considered potentially high risk, but it has low pathogenicity and slow rates of progression [32]. Of these high-risk varieties, HPV-16 and HPV-18 are most strongly associated with cancer occurrence [33,34], and HPV-16 is a relatively common strain [35].…”