Clinical characteristics of pulmonary artery involvement in patients with Behçet’s syndrome: single-centre experience of 61 patients

Eroglu, Didem Sahin; Torğutalp, Murat; Baysal, Serdar; Çolaklar, Anıl; Sezer, Serdar; Yayla, Müçteba Enes; Uzun, Çağlar; Turgay, Tahsin Murat; Kınıklı, Gülay; Ateş, Aşkın

doi:10.1007/s10067-021-05748-x

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…Behcet's disease-related pulmonary damage is relatively rare. Similar to this study, previous studies found that slight hemoptysis accompanied by low fever and dyspnea was common in patients at an early stage [1] . An insufficient understanding of pulmonary imaging of Behcet's disease-related pulmonary damage results in serious missed diagnosis and misdiagnosis of the disease.…”

supporting

confidence: 82%

“…Similar to this study, previous studies found that slight hemoptysis accompanied by low fever and dyspnea was common in patients at an early stage. [1] An insufficient understanding of pulmonary imaging of Behcet's disease-related pulmonary damage results in serious missed diagnosis and misdiagnosis of the disease. This study focused on the CTPA characteristics of Behcet's disease-related pulmonary damage.…”

mentioning

confidence: 99%

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Analysis of clinical and imaging features of Behcet's disease-related pulmonary lesions: a series of eight cases

Zhang

Yang

Kuang

et al. 2022

Chinese Medical Journal

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supporting

confidence: 82%

mentioning

confidence: 99%

Analysis of clinical and imaging features of Behcet's disease-related pulmonary lesions: a series of eight cases

Zhang

Yang

Kuang

et al. 2022

Chinese Medical Journal

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“…Lower-lobe arteries are mainly involved in both cases of PAI (PAAs and PAT), the number of vessels involved is significantly lower in patients with isolated PAT. These have similar clinical features to those with PAAs, although massive hemoptysis is observed less frequently in patients with isolated PAT [ 50 , 51 ]. In the case of isolated PAT, CXR could be normal; thus CT scanning is an optimal noninvasive imaging modality for initial and follow-up evaluations [ 35 , 52 , 53 ].…”

Section: Imaging Approach To Thoracic Involvement In Behcet’s Diseasementioning

confidence: 99%

“…The acute symptoms are usually facial swelling, dyspnea, fever, hemoptysis, and palpitation [ 86 , 89 ]. ICT is frequently associated with pulmonary arterial or venous thrombosis and endomyocardial fibrosis; therefore, it is difficult to demonstrate whether the thrombi are secondary to these conditions or are caused by a de novo process [ 51 ]. CTPA and MRI can show a filling defect in the ventricle and can provide additional information, such as the presence of pulmonary arterial thromboembolism or a lung parenchymal lesion.…”

Section: Imaging Approach To Thoracic Involvement In Behcet’s Diseasementioning

confidence: 99%

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

et al. 2022

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Behcet’s disease (BD) is a chronic systemic inflammatory disorder characterized by underlying chronic vasculitis of both large- and small-caliber vessels. Thoracic involvement in BD can occur with various types of manifestations, which can be detected with contrast-enhanced MSCT scanning. In addition, MR can be useful in diagnosis. Characteristic features are aneurysms of the pulmonary arteries that can cause severe hemoptysis and SVC thrombosis that manifests as SVC syndrome. Other manifestations are aortic and bronchial artery aneurysms, alveolar hemorrhage, pulmonary infarction, and rarely pleural effusion. Achieving the right diagnosis of these manifestations is important for setting the correct therapy and improving the patient’s outcome.

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“…15,16 Pulmonary arterial thrombotic lesions resolve slowly by immunosuppressive treatment in BD; incomplete healing with sequelae vascular changes is not rare. 4,24 Therefore, thrombosis in pulmonary circulation should resemble more chronic thrombosis than acute. Two of our eight patients had both acute and chronic thrombosis, and most of the patients had chronic vascular changes in their control CT evaluations that reflect a typical late-resolving feature of BD thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography imaging‐based radiologic evaluation of pulmonary artery thrombosis in a series of patients with Behcet's disease

Germe,

Ozsoy,

Bulat

et al. 2024

Int J of Rheum Dis

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AimPulmonary artery involvement is a severe complication of Behcet's disease (BD). Although venous thrombosis is common in BD, pulmonary embolism is considered to be rare because the inflammatory nature makes the thrombi strongly adherent to the venous walls. This study aimed to define the radiological characteristics of pulmonary artery thrombosis (PAT) on computed tomography (CT) imaging in BD patients.MethodsWe retrospectively evaluated 165 BD patients with vascular involvement. Among the patients with venous involvement (n = 146), we identified 65 patients who had undergone thorax CT imaging previously. Fourteen patients who were diagnosed with PAT were included in the study. Expert radiologists re‐evaluated the patients' initial and control thorax CT scans, classified the PAT as acute or chronic based on their radiological features.ResultsThe patients' median age was 35 (min–max: 15–60) years at the time of the initial CT scan, and nine were male. Twelve (85.7%) patients were symptomatic at the time of CT evaluation. Upon re‐evaluating the thorax CTs, acute PAT was diagnosed in six (42.8%); chronic PAT was detected in eight (57.1%) patients. Two patients with chronic PAT also had acute PAT. Pulmonary artery aneurysms were present in three (21.4%) patients, and intracardiac thrombus was found in three (21.4%) patients.ConclusionA significant number of BD patients with venous involvement had radiological findings consistent with acute PAT potentially due to pulmonary emboli in this study. The clinical importance of these lesions has to be defined with future studies.

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Clinical characteristics of pulmonary artery involvement in patients with Behçet’s syndrome: single-centre experience of 61 patients

Cited by 6 publications

References 30 publications

Analysis of clinical and imaging features of Behcet's disease-related pulmonary lesions: a series of eight cases

Analysis of clinical and imaging features of Behcet's disease-related pulmonary lesions: a series of eight cases

Behçet’s Disease: A Radiological Review of Vascular and Parenchymal Pulmonary Involvement

Computed tomography imaging‐based radiologic evaluation of pulmonary artery thrombosis in a series of patients with Behcet's disease

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