Clinical characteristics of pruritus in chronic idiopathic urticaria

Yosipovitch, Gil; Ansari, Noureddin Nakhostin; Goon, Anthony Teik‐Jin; Chan, Yiong Huak; Goh, Chee Leok

doi:10.1046/j.1365-2133.2002.04758.x

Cited by 127 publications

(92 citation statements)

References 9 publications

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“…Wheals are short-lived elevated erythematous lesions ranging from a few millimeters to several centimeters in diameter and can become confluent. 1 Angioedema is an acute, evanescent, circumscribed edema that usually affects the eyelids, lips, lobes of the ears, and external genitalia, mucous membrane of gastrointestinal and respiratory tracts, resulting in abdominal pain, coryza and asthma. The swelling occurs in the deeper parts of the skin or the subcutaneous tissues.…”

Section: Introductionmentioning

confidence: 99%

Association of chronic urticaria with Helicobacter Pylori infection in Erbil: A case-control study

Muhemmed¹,

Mohammed

2016

ZJMS

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4Recent observations had suggested a possible Background and objective: Chronic urticaria is one of the most frequent skin diseases and still its etiology is recognized only in a minority of cases. Some recent studies point out to infections due to Helicobacter Pylori as being of major importance in the pathogenesis of chronic urticaria. This study aimed to find out the association of chronic urticaria with H. pylori. Methods: A case-control study was conducted in Erbil city within the period of April 1 st , 2013 to January 1 st , 2014. The study included 55 cases with chronic urticaria and 55 controls that were free from features of chronic urticaria. Data was collected through direct interview and the results of laboratory investigations were recorded in a specially designed questionnaire. Enzyme-linked immunosorbent assay test was used for detection of Helicobacter pylori antigen in the stool sample. Results: The age of the 55 cases and 55 controls enrolled ranged from 13 to 65 years. Stool for Helicobacter pylori antigen test was positive in 69.1% of cases and 29.1% of controls (OR = 5.44, P ˂0.001). The mean age ± SD of positive Helicobacter pylori patients were 35.75 ± 12.64 years, with male to female ratio 1:2.8. No statistically significant association was found between Helicobacter Pylori infection with dyspepsia and duration of urticaria. Conclusions: There was a strong association of chronic urticaria with Helicobacter pylori infection. Investigating for Helicobacter pylori in all cases of chronic urticaria and conducting further trials on Helicobacter pylori eradication is recommended.

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Section: Introductionmentioning

confidence: 99%

Association of chronic urticaria with Helicobacter Pylori infection in Erbil: A case-control study

Muhemmed¹,

Mohammed

2016

ZJMS

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“…Pruritus affects different physical, social and psychological aspects of the life. It can cause sleep disturbances, agitation, and anxiety and can reduce concentration, sexual desire and sexual function (1,3,(7)(8)(9). Therefore, treatment of pruritus is an important point in the management of many skin and systemic diseases.…”

Section: Introductionmentioning

confidence: 99%

Role of Pregabalin in Management of Pruritus: A Literature Review

Foroutan

Nikvarz

2016

J Pharm Pharm Sci

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-Purpose. Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation. Hence, effective drugs in reducing the neuropathic pain such as pregabalin have been studied and used in the management of different itchy conditions. In this narrative review we considered the available published papers dealing with the antipruritic effects of pregabalin. Results of studies conducted in uremic patients show that pregabalin is an effective option in reducing uremic pruritus especially in those who have not responded to antihistamines and topical moisturizers. Data about the effects of pregabalin on other itchy conditions are very limited; however results of the available studies show beneficial effects of this drug in burn patients with more than 5% involvement of the total body surface area, in prurigo nodularis, and in chronic and idiopathic itch. One considerable issue is that the therapeutic effects of pregabalin on uremic pruritus and post burn itch may appear more rapidly than its effects in the other conditions (1-2 weeks vs > 4 weeks). The most reported adverse effects of pregabalin are sedation, dizziness and drowsiness. Whether pregablin can be unequivocally considered as an effective and reasonable choice in the management of pruritus with different causes is a question that should be answered through large scale randomized controlled studies.

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“…Some studies have used questionnaires to evaluate pruritus by targeting a single type of dermatitis, for example, studying atopic dermatitis (AD) with the "Eppendorf Itch Questionnaire" (1,2), and uraemic pruritus (3). Questionnaires have also been used to study psoriasis (4) and urticaria (5). The pathophysiological mechanisms of itch, especially with regard to the mediators and transmitters involved, can vary according to the itch-inducing disease.…”

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confidence: 99%

Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and Scabies

Brenaut¹,

Garlantézec²,

Talour³

et al. 2013

Acta Derm Venerol

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Clinical characteristics of pruritus in chronic idiopathic urticaria

Abstract: This study describes the itch experienced in CIU, highlighting sensory and affective dimensions. The itch questionnaire was found to be a valuable tool for evaluating pruritus in CIU and its unique features.

Cited by 127 publications

References 9 publications

Association of chronic urticaria with Helicobacter Pylori infection in Erbil: A case-control study

Association of chronic urticaria with Helicobacter Pylori infection in Erbil: A case-control study

Role of Pregabalin in Management of Pruritus: A Literature Review

Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and Scabies

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