Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype

Gourier, Greta; Théréné, C.; Mazeas, Margaux; Abasq‐Thomas, C.; Brenaut, E.; Huet, F.; Sonbol, Haitham; Campillo, Elize; Lemerle, Julie; Pasquier, Elisabeth; Moigne, Emmanuelle Le; Saraux, Alain; Devauchelle‐Pensec, Valérie; Miséry, Laurent; Renaudineau, Yves

doi:10.2340/00015555-2980

Cited by 11 publications

(9 citation statements)

References 34 publications

(45 reference statements)

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“…39 The prevalence of CP in SSc is reported to be 43-62% with a profound impact on quality of life. [40][41][42] SSc-associated pruritus is likely due to a combination of sensory nerve fibre entrapment from collagen deposition as well as direct stimulation of nerve fibres by the same Th2 mediated immune processes that drives the disease. Specifically, serum levels of IL-4 and IL-13 are elevated in patients with SSc.…”

Section: Systemic Sclerosismentioning

confidence: 99%

“…Systemic Sclerosis (SSc) is an autoimmune connective tissue disorder characterized by abnormal fibrotic processes and excessive collagen production resulting in fibrosis of the skin and internal organs 39 . The prevalence of CP in SSc is reported to be 43–62% with a profound impact on quality of life 40–42 . SSc‐associated pruritus is likely due to a combination of sensory nerve fibre entrapment from collagen deposition as well as direct stimulation of nerve fibres by the same Th2 mediated immune processes that drives the disease.…”

Section: The Role Of the Th2 Immune Response In Chronic Pruritic Cond...mentioning

confidence: 99%

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The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Ingrasci

Lipman

Hawash

et al. 2021

Experimental Dermatology

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While there is a vast array of aetiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including Th2 T Cells and their related cytokines, has been noted to play a major role in the development of pruritus in a variety of itchy conditions. To date, atopic dermatitis is the most striking example of this pathogenesis. However, the body of literature supporting its role in many other itchy conditions, including other inflammatory, bullous, as well as systemic diseases, continues to grow. In addition, new treatments targeting this type 2 immune system continue to be developed and investigated. In the current review, we present the current body of literature supporting the role of the type 2 immune response in itchy conditions beyond atopic dermatitis as well as potential therapeutic options that target this pathway for chronic itch.

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Section: Systemic Sclerosismentioning

confidence: 99%

Section: The Role Of the Th2 Immune Response In Chronic Pruritic Cond...mentioning

confidence: 99%

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Ingrasci

Lipman

Hawash

et al. 2021

Experimental Dermatology

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show abstract

“…Skin involvement is characterized by variable extent and severity of skin thickening and hardening with edematous swelling and erythema. With a prevalence of 40–65%, pruritus is a common symptom of SSc, which occurs not only in the affected areas but also often on the extremities or generalized (60). In addition to pruritus, patients experience stinging, burning and pain, which suggests that pruritus in SSc has a neuropathic component (61) caused by compression of small NF by thickened collagen.…”

Section: Connective Tissue Diseasesmentioning

confidence: 99%

Pruritus in Autoimmune and Inflammatory Dermatoses

et al. 2019

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Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. In some diseases, pruritus is related to disorders activity and severity or may occur independent of the disease. Despite the high prevalence, the symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. In this review, the characteristics and possible pathomechanisms of pruritus in various dermatoses like autoimmune bullous diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, psoriasis vulgaris) is illustrated. Additionally, studies analyzing the antipruritic treatment are discussed. Summarizing, the prevalence of pruritus in these diseases demonstrates the importance for symptom recognition and the need for an efficient antipruritic therapy.

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“…Pruritus is not specifically associated with a particular immunological profile, whereas the autoimmune status has been associated with the characteristics of pruritus in SSc. The presence of ACA has been reported to be associated with the duration, location, and appearance order of pruritus against skin symptoms (46). In that study, ACA+ patients had a longer period of pruritus than the ACA-subgroup, and pruritus predominantly occurred in nonsclerotic areas (82.4%).…”

Section: Sscmentioning

confidence: 82%

Pruritus in autoimmune connective tissue diseases

Kim

2021

Ann Transl Med

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Pruritus is one of the most common and bothersome symptoms of skin disorders, and its clinical characteristics and related pathomechanisms have been well described in certain dermatologic conditions, such as atopic dermatitis and urticaria. Although pruritus is believed to be as common in cutaneous autoimmune connective tissue diseases (ACTDs) as in other inflammatory skin disorders, its true characteristics have not been elucidated either qualitatively or quantitatively. Pruritus is present in ACTDs with various prevalence rates, characteristics, and mechanisms depending on the disease types. Pruritus most frequently and severely affects the patients with dermatomyositis, in which itch is strongly correlated with disease activity and severity, thus increased itch could also indicate a disease flare. Patients with other ACTDs, including lupus erythematosus (LE), Sjögren syndrome (SS), morphea, and systemic sclerosis (SSc), also suffer from their fair share of pruritus. Unfortunately, the currently available treatments for ACTDs seem to have only limited and unsatisfactory effects to control pruritus. The extensive impact of pruritus on the patients' quality of life (QOL) and functioning warrants more targeted and individualized approaches against pruritus in ACTDs. This review will address the prevalence, suggested pathogenesis based on currently available evidences, and potential treatment options of pruritus in various ACTDs of the skin.

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Clinical Characteristics of Pruritus in Systemic Sclerosis Vary According to the Autoimmune Subtype

Cited by 11 publications

References 34 publications

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Pruritus in Autoimmune and Inflammatory Dermatoses

Pruritus in autoimmune connective tissue diseases

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