Clinical Characteristics of Pregnant Women With Coronavirus Disease 2019 in Wuhan, China

Cheng, Biheng; Jiang, Tao; Zhang, Lu; Hu, Ruheng; Tian, Jian; Jiang, Yan; Huang, Bo; Li, Jun; Wei, Min; Yang, Jing; Ren, Shengxiang; Wang, Gaohua

doi:10.1093/ofid/ofaa294

Cited by 29 publications

(22 citation statements)

References 22 publications

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“…From Denmark, a cohort study did not find ultrasound evidence of fetal compromise during first trimester infections nor increased pregnancy loss [ 18 ]. The latter was supported by comparative studies in which infected pregnant patients were compared to either non-infected pregnancies, non-pregnant infected females in the community, or patients with alternative virus infections [ 19 – 24 ]. In this context, the study of Wei et al stands out in that both pregnant and nonpregnant controls equally had a high rate of influenza virus co-detection [ 17 ].…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…The latter was also found in an Iranian population, but more COVID-19-infected pregnancies required intensive care [ 25 ]. In the study of Cheng et al, pregnancies with COVID-19 were said to have less severe disease than non-pregnant patients, but the control group was significantly older for age [ 19 ]. Evidently, the pre-selection of the patient population for testing influences the likelihood of severe disease [ 26 ].…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…Severe respiratory disease requiring extra-ordinary treatment or monitoring is consistently described [ 2 , 10 , 13 , 14 , 19 , 28 , 30 – 33 , 39 – 41 , 43 , 44 , 46 , 47 , 59 , 61 , 66 – 91 ]. Cardiac disease may accompany the latter [ 92 ].…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…Co-morbidities among pregnant patients with COVID-19 infection are common [ 115 ]. Co-morbidities are very common, however, in those with more aggressive illnesses, and these have especially included obesity and diabetes [ 1 , 2 , 12 , 14 , 19 , 28 , 30 , 31 , 33 , 34 , 38 – 40 , 42 , 68 , 79 – 81 , 88 , 89 , 94 , 96 , 105 , 110 , 116 ]. The anticipation of potential complications or the advanced nature of disease has led to a high rate of Caesarean section [ 1 – 3 , 10 , 21 – 23 , 25 , 29 – 32 , 35 , 38 – 42 , 51 , 55 , 56 , 59 , 60 , 68 , 74 – 77 , 82 , 87 , 94 , 101 , 105 , 107 , 109 – 115 , 117 – 129 ].…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…In a large American cohort, perinatal COVID-19 infection was estimated at 2.6% [ 108 ]. Most studies, however, report an infrequency of neonatal SARS-CoV-2 infection at birth or thereafter despite maternal infection of varying severity [ 1 – 3 , 13 , 16 , 19 , 20 , 22 – 25 , 29 , 30 , 35 , 38 , 41 , 42 , 46 , 47 , 51 , 55 , 59 – 61 , 66 , 68 , 72 , 82 , 90 , 100 , 104 – 107 , 109 , 110 , 112 , 113 , 117 – 120 , 123 , 126 , 128 , 129 , 139 , 162 , 168 , 185 , 188 , 191 , 193 , 196 , 197 , 213 , 222 , 228 , 237 – 244 ]. The latter has also been evident despite some newborn exposure to maternal breastfeeding [ 82 , 118 , 127 , 136 , 241 ].…”

Section: Antenatal or Neonatal Infection With Sars-cov-2mentioning

confidence: 99%

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A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Antenatal or Neonatal Infection With Sars-cov-2mentioning

confidence: 99%

See 3 more Smart Citations

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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Fetal and placental infection with SARS‐CoV‐2 in early pregnancy

Valdespino-Vázquez

Helguera-Repetto

León-Juárez

et al. 2021

Journal of Medical Virology

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To date, mother-to-fetus transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19) pandemic, remains controversial. Although placental COVID-19 infection has been documented in some cases during the second-and third-trimesters, no reports are available for the first trimester of pregnancy, and no SARS-CoV-2 protein has been found in fetal tissues. We studied the placenta and fetal organs from an early pregnancy miscarriage in a COVID-19 maternal infection by immunohistochemical, reverse

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Postoperative mortality in the COVID-positive hip fracture patient, a systematic review and meta-analysis

Isla

Landy

Teasdall

et al. 2022

Eur J Orthop Surg Traumatol

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PurposeThe extent to which concomitant COVID-19 infection increases short-term mortality following hip fracture is not fully understood. A systemic review and meta-analysis of COVID-19 positive hip fracture patients (CPHFPs) undergoing surgery was conducted to explore the association of COVID-19 with short-term mortality. Methods Review of the literature identified reports of short-term 30-day postoperative mortality in CPHFPs. For studies including a contemporary control group of COVID-19 negative patients, odds ratios of the association between COVID-19 infection and short-term mortality were calculated. Short-term mortality and the association between COVID-19 infection and short-term mortality were meta-analyzed and stratified by hospital screening type using random effects models. Results Seventeen reports were identified. The short-term mortality in CPHFPs was 34% (95% C.I., 30-39%). Short-term mortality differed slightly across studies that screened all patients, 30% (95% C.I., 22-39%), compared to studies that conditionally screened patients, 36% (95% C.I., 31-42%), (P = 0.22). The association between COVID-19 infection and short-term mortality produced an odds ratio of 7.16 (95% C.I., 4.99-10.27), and this was lower for studies that screened all patients, 4.08 (95% C.I., 2.31-7.22), compared to studies that conditionally screened patients, 8.32 (95% C.I., 5.68-12.18), (P = 0.04). Conclusion CPHFPs have a short-term mortality rate of 34%. The odds ratio of short-term mortality was significantly higher in studies that screened patients conditionally than in studies that screened all hip fracture patients. This suggests mortality prognostication should consider how COVID-19 infection was identified as asymptomatic patients may fare slightly better.

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Clinical Characteristics of Pregnant Women With Coronavirus Disease 2019 in Wuhan, China

Abstract: Abstract Background Coronavirus disease 2019 (COVID-19) has become a pandemic. Despite of the growing number of patients with COVID-19 infection, data on the clinical characteristics of pregnant patients is still limited. Methods We retrospectively included childb… Show more

Cited by 29 publications

References 22 publications

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Fetal and placental infection with SARS‐CoV‐2 in early pregnancy

Postoperative mortality in the COVID-positive hip fracture patient, a systematic review and meta-analysis

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