Clinical characteristics of peanut allergy

Hourihane, Jonathan; Kilburn, Sally; DEAN, P.; Warner, J. O.

doi:10.1046/j.1365-2222.1997.d01-559.x

Cited by 57 publications

(86 citation statements)

References 4 publications

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“…Peanut allergy frequently becomes manifest early in life and, in more than 74% of cases, following the first oral exposure to peanuts [12,13]. This observation has led to an investigation of other possible routes of first exposure (and thus, sensitization), including in utero, via breast milk, and via exogenous application of peanut-protein containing oils, especially to disrupted skin [14][15][16].…”

Section: Introductionmentioning

confidence: 96%

Genetics of food allergy

Dreskin

2006

Curr Allergy Asthma Rep

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Allergic reactions to foods are an important medical problem throughout the industrialized world. The occurrence of food allergy appears to be strongly influenced by genetics, but the basis of the genetic predisposition to food allergy has not been differentiated from that for atopy in general. In addition, genetic susceptibility alone does not explain the prevalence of food allergy satisfactorily, leaving ample room to consider the importance of environmental influences (external, maternal, and gastrointestinal environment) and interactions between the host and the environment. Several features of food allergy are highlighted in this review: 1) patients with severe food allergies are overwhelmingly atopic, but food allergy occurs only in approximately 10% of patients with other atopic diseases; 2) most patients are clinically reactive to a single food, and although a substantial minority have multiple food allergies, the variety of bone fide food allergies in a given individual is limited; 3) foods contain multiple proteins whereas only a small subset are allergenic; 4) there is likely an important contribution of the environment, becoming manifest in genetically susceptible individuals.

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Section: Introductionmentioning

confidence: 96%

Genetics of food allergy

Dreskin

2006

Curr Allergy Asthma Rep

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“…The allergy to peanut is characterized by more severe symptoms than other food allergies and by a high rate of symptoms on minimal contact [3,4]. The incidence of peanut, and food allergies in general, has increased in the recent decades.…”

Section: Introductionmentioning

confidence: 99%

Peanut-lupine antibody cross-reactivity is not associated to cross-allergenicity in peanut-sensitized mouse strains

Lifrani

Dubarry

Rautureau

et al. 2005

International Immunopharmacology

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“…However, 72% to 81% of presentations of PA occur on first known exposure to peanut. [2][3][4] Public health measures to prevent peanut and other food allergies in the United States and United Kingdom (UK) have focused on allergen exclusion by the mother during pregnancy and lactation, and by the child in the first 3 years of life. 5,6 Despite this advice, there is evidence to suggest that PA continues to rise in these countries, 7 and randomized interventional studies have not shown an effect on preventing PA by avoiding ingestion during gestation, lactation, or infancy.…”

mentioning

confidence: 99%