Clinical Characteristics of Patients with Acute Ischemic Stroke Previously Vaccinated Against COVID-19

Correspondence on “Patients with Acute Ischemic Stroke Previously Vaccinated Against COVID-19”

“…Dear Editor, we read and follow the publication on the “Clinical Characteristics of Patients with Acute Ischemic Stroke Previously Vaccinated Against COVID-19” saga. 1 There are no significant variations in clinical characteristics of stroke in vaccinated versus unvaccinated patients, according to Stamenkovi et al We found no evidence of a link between vaccination and stroke. 1 Since the basic Wirchow's triad is the accepted explanation for the pathophysiological process of the stroke, we agree that there should be no difference in the pathogenesis of the stroke in cases with and without vaccination history.…”

“… 1 There are no significant variations in clinical characteristics of stroke in vaccinated versus unvaccinated patients, according to Stamenkovi et al We found no evidence of a link between vaccination and stroke. 1 Since the basic Wirchow's triad is the accepted explanation for the pathophysiological process of the stroke, we agree that there should be no difference in the pathogenesis of the stroke in cases with and without vaccination history. It's usually difficult to find a link between immunization and stroke.…”

COVID-19 and Acute Ischemic Stroke Mortality and Clinical Outcomes among Hospitalized Patients in the United States: Insight from National Inpatient Sample

“…There have been concerns surrounding COVID-19 vaccination with DNA and mRNA vaccines and the potential development of complications, such as acute ischemic stroke [ 47 , 48 ]. In Kolahchi et al, reportedly 22 cases (51.1% of that study’s cohort) developed AIS associated with the vaccine-induced immune thrombotic thrombocytopenia (VITT; thrombocytopenia and antibodies against platelet factor 4 leading to thrombosis) four weeks after all, except one patient, received a viral vector vaccine out of > 1.3 billion (< 0.000%) COVID-19 administered vaccinations from December, 2020, to December, 2021 [ 47 , 49 ].…”

“…In Kolahchi et al, reportedly 22 cases (51.1% of that study’s cohort) developed AIS associated with the vaccine-induced immune thrombotic thrombocytopenia (VITT; thrombocytopenia and antibodies against platelet factor 4 leading to thrombosis) four weeks after all, except one patient, received a viral vector vaccine out of > 1.3 billion (< 0.000%) COVID-19 administered vaccinations from December, 2020, to December, 2021 [ 47 , 49 ]. In contrast, Stamenkovic et al found no connection between vaccination and stroke [ 48 ]. Based on these publications, the benefits outweigh the risks of vaccination (i.e., decreased severity of COVID-19 infection, hospitalization, mortality, etc.)…”

Response to the Letter to the Editor by Mungmunpuntipantip et al

“…1 Nevertheless, we agree with the statement that our study lacks the data on the vaccine recipients' pre-vaccination thrombo-hemostatic condition, and that could be one of the limitation of our study. 2,3 Also, it is a good idea for further research.…”